The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways
Open accessAbstract
Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of excessive inflammation is cell and tissue damage, an underlying cause of many acute and chronic diseases. Coincident with activation of TLR signaling, a plethora of anti-inflammatory pathways and mechanisms begin to modulate inflammation until tissue repair is complete. Whereas most studies have focused on the signaling components immediately downstream of the TLRs, this Review summarizes the different levels of anti-inflammatory pathways that have evolved to abate TLR signaling and how they are integrated to prevent cell and tissue destruction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Expression of the M1 phenotype is regulated by transcription factors such as NF-κB, IRF-3, and IRF-5 [189,190,191].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [189]
Experimental — accuracy not yet measuredIn the citing paper
“The treatment of rats, mice, and pigs with GHK was shown to effectively activate systemic healing throughout the animal.”
From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Self-citationInterleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,064
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726
Flagged first, then by citations
1 of the 120 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Regulation of pattern recognition receptor signalling in plants
Couto, D., & Zipfel, C. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.77 · Cited by 1,400
A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes
Carpenter, S. B., Aiello, D. A., Atianand, M., Ricci, E. P., Gandhi, P., Hall, L. L., Byron, M., Monks, B. G., Henry-Bezy, M., Lawrence, J. B., et al. (2013) · Science · doi:10.1126/science.1240925 · Cited by 957
Wu, J.-Y., Huang, T., Hsieh, Y.-T., Wang, Y., Yen, C.-C., Lee, G.-L., Yeh, C., Peng, Y., Kuo, Y.-Y., Wen, H.-T., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.023 · Cited by 549
Toll-like receptors: Activation, signalling and transcriptional modulation
Nardo, D. D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.025 · Cited by 484
The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges
Hutchins, A. P., Díez, D., & Miranda‐Saavedra, D. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt028 · Cited by 435
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines
Banchereau, J., Pascual, V., & O’Garra, A. (2012) · Nature Immunology · doi:10.1038/ni.2406 · Cited by 409
Contribution of metabolic reprogramming to macrophage plasticity and function
Kasmi, K. C. E., & Stenmark, K. R. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.09.001 · Cited by 281
Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease
Golpich, M., Amini, E., Hemmati, F., Ibrahim, N. M., Rahmani, B., Mohamed, Z., Raymond, A. A., Dargahi, L., Ghasemi, R., & Ahmadiani, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.03.010 · Cited by 282
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation
Du, M., Yuan, L., Tan, X., Huang, D., Wang, X., Zheng, Z., Mao, X., Li, X., Yang, L., Huang, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02229-1 · Cited by 264
The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection
Harding, A. T., & Heaton, N. S. (2022) · Cancers · doi:10.3390/cancers14040909 · Cited by 278
Exacerbated and prolonged inflammation impairs wound healing and increases scarring
Qian, L., Fourcaudot, A. B., Yamane, K., You, T., Chan, R. K., & Leung, K. P. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12381 · Cited by 204
Rajbhandari, P., Thomas, B. J., Feng, A., Hong, C., Wang, J., Vergnes, L., Sallam, T., Wang, B., Sandhu, J., Seldin, M. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.019 · Cited by 190
Self-citationRoles of Macrophages in the Development and Treatment of Gut Inflammation
Han, X., Ding, S., Jiang, H., & Liu, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.625423 · Cited by 196
Hossain, D. M. S., Pal, S. K., Moreira, D., Duttagupta, P. A., Zhang, Q., Won, H., Jones, J. O., D’Apuzzo, M., Forman, S. J., & Kortylewski, M. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3145 · Cited by 192
Circulating inflamma-miRs in aging and age-related diseases
Olivieri, F., Rippo, M. R., Procopio, A. D., & Fazioli, F. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00121 · Cited by 184
Anti‐inflammatory cytokines and risk of type 2 diabetes
Herder, C., Carstensen, M., & Ouwens, D. M. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12155 · Cited by 172
Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease
Hoang, L. T., Shimizu, C., Ling, L., Naim, A. N. M., Khor, C. C., Tremoulet, A. H., Wright, V., Levin, M., Hibberd, M. L., & Burns, J. C. (2014) · Genome Medicine · doi:10.1186/s13073-014-0102-6 · Cited by 174
Goldszmid, R. S., & Trinchieri, G. (2012) · Nature Immunology · doi:10.1038/ni.2422 · Cited by 175
Rhee, S. H. (2014) · Intestinal Research · doi:10.5217/ir.2014.12.2.90 · Cited by 171
Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway
Ng, W. L., Marinov, G. K., Liau, E. S., Lam, Y. L., Lim, Y., & Ea, C.-K. (2016) · RNA Biology · doi:10.1080/15476286.2016.1207036 · Cited by 156
Kang, K., Bachu, M., Park, S. H., Kang, K., Bae, S., Park‐Min, K., & Ivashkiv, L. B. (2019) · Nature Communications · doi:10.1038/s41467-019-11147-3 · Cited by 145
Toll like receptor signaling in “inflammaging”: microRNA as new players
Olivieri, F., Rippo, M. R., Prattichizzo, F., Babini, L., Graciotti, L., Recchioni, R., & Procopio, A. D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-11 · Cited by 141
miR-27a regulates inflammatory response of macrophages by targeting IL-10
Xie, N., Cui, H., Banerjee, S., Tan, Z., Salomao, R., Fu, M., Abraham, E., Thannickal, V. J., & Liu, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400203 · Cited by 128
A critical role for interleukin-1β in the progression of autoimmune diseases
Zhao, R., Zhou, H., & Su, S. B. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.08.012 · Cited by 123
STAT3 in Tumor-Associated Myeloid Cells: Multitasking to Disrupt Immunity
Su, Y., Banerjee, S., White, S. V., & Kortylewski, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061803 · Cited by 125
miRNA-124 in Immune System and Immune Disorders
Qin, Z., Wang, P., Su, D., & Liu, X. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00406 · Cited by 116
Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis
Gao, M., Tang, M., Ho, W., Teng, Y., Chen, Q., Bu, L., Xu, X., & Zhang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c00958 · Cited by 108
Long non-coding RNAs in innate and adaptive immunity
Aune, T. M., & Spurlock, C. F. (2015) · Virus Research · doi:10.1016/j.virusres.2015.07.003 · Cited by 105
Essential role of IL-10/STAT3 in chronic stress-induced immune suppression
Hu, D., Wan, L., Chen, M., Caudle, Y., LeSage, G., Li, Q., & Yin, D. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.016 · Cited by 100
The vaccine adjuvant alum promotes IL‐10 production that suppresses Th1 responses
Oleszycka, E., McCluskey, S., Sharp, F. A., Muñoz‐Wolf, N., Hams, E., Gorman, A. L., Fallon, P. G., & Lavelle, E. C. (2018) · European Journal of Immunology · doi:10.1002/eji.201747150 · Cited by 101
Pristane-induced lupus: considerations on this experimental model
Freitas, E. C., de Oliveira, M. S., & Monticielo, O. A. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3811-6 · Cited by 97
Mahajan, S., Saini, A., Chandra, V., Nanduri, R., Kalra, R., Bhagyaraj, E., Khatri, N., & Gupta, P. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638064 · Cited by 92
Maintaining system homeostasis: the third law of Newtonian immunology
Germain, R. N. (2012) · Nature Immunology · doi:10.1038/ni.2404 · Cited by 88
TLR9 Signaling in the Tumor Microenvironment Initiates Cancer Recurrence after Radiotherapy
Gao, C., Kozłowska, A. K., Nechaev, S., Li, H., Zhang, Q., Hossain, D. M. S., Kowolik, C. M., Chu, P. G., Swiderski, P. M., Diamond, D. J., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1314 · Cited by 89
Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing
Arras, L. D., & Alper, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003855 · Cited by 88
Sun, K., Xu, D., Xie, C., Plummer, S., Tang, J. Z., Yang, X. F., & Ji, X. H. (2017) · Cytokine · doi:10.1016/j.cyto.2017.01.003 · Cited by 85
Gopalakrishnan, A., & Salgame, P. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.06.003 · Cited by 88
Liu, X., Zhang, P., Bao, Y., Han, Y., Wang, Y., Zhang, Q., Zhan, Z., Meng, J., Li, Y., Li, N., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301257110 · Cited by 82
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus
Zhuang, H., Han, S., Lee, P. Y., Khaybullin, R. N., Shumyak, S. P., Lu, L., Chatha, A., Afaneh, A. B., Zhang, Y., Xie, C., et al. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40077 · Cited by 80
Maxeiner, H., Schneider, E. M., Kurfiss, S.-T., Brettschneider, J., Tumani, H., & Bechter, K. (2014) · Cytokine · doi:10.1016/j.cyto.2014.05.008 · Cited by 79
Bae, S., Park, P. S. U., Lee, Y., Mun, S. H., Γιαννοπούλου, Ε., Fujii, T., Lee, K. P., Violante, S. N., Cross, J. R., & Park‐Min, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109264 · Cited by 81
Airway structural cells regulate TLR5-mediated mucosal adjuvant activity
Maele, L. V., Fougeron, D., Janot, L., Didierlaurent, A. M., Cayet, D., Tabareau, J., Rumbo, M., Corvo-Chamaillard, S., Boulenouar, S., Jeffs, S. A., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.66 · Cited by 76
Mishra, B., Bachu, M., Yuan, R., Wingert, C. K., Chaudhary, V., Brauner, C., Bell, R. D., & Ivashkiv, L. B. (2025) · Nature Immunology · doi:10.1038/s41590-025-02137-3 · Cited by 80
MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response
Yu, L., Fang, F., Dai, X. J., Xu, H., Qi, X., Fang, M., & Xu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00301-w · Cited by 71
Macrophages employ quorum licensing to regulate collective activation
Muldoon, J. J., Chuang, Y., Bagheri, N., & Leonard, J. N. (2020) · Nature Communications · doi:10.1038/s41467-020-14547-y · Cited by 70
Ajmone‐Cat, M. A., D’Urso, M. C., di Blasio, G., Brignone, M. S., Simone, R. D., & Minghetti, L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.11.012 · Cited by 68
Crowley, T., O’Neil, J. D., Adams, H., Thomas, A. M. C., Filer, A. D., Buckley, C. D., & Clark, A. R. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1248-6 · Cited by 67
Hutchins, A. P., Takahashi, Y., & Miranda‐Saavedra, D. (2015) · Scientific Reports · doi:10.1038/srep09100 · Cited by 64
Qiu, P., Li, J., Zhang, L., Chen, K., Shao, J., Zheng, B., Yuan, H., Qi, J., Yue, L., Hu, Q., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43192-4 · Cited by 63
Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex
O’Connor, B. P., Danhorn, T., Arras, L. D., Flatley, B. R., Marcus, R. A., Farias‐Hesson, E., Leach, S. M., & Alper, S. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004932 · Cited by 64
Moreira, D., Zhang, Q., Hossain, D. M. S., Nechaev, S., Li, H., Kowolik, C. M., D’Apuzzo, M., Forman, S. J., Jones, J. O., Pal, S. K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4029 · Cited by 62
A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes
Zugasti, O., Thakur, N., Belougne, J., Squiban, B., Kurz, C. L., Soulé, J., Omi, S., Tichit, L., Pujol, N., & Ewbank, J. J. (2016) · BMC Biology · doi:10.1186/s12915-016-0256-3 · Cited by 60
Li, H. Z., Hu, D., Fan, H., Zhang, Y., LeSage, G., Caudle, Y., Stuart, C. A., Liu, Z., & Yin, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591495 · Cited by 55
Involvement of MyD88 in zinc oxide nanoparticle-induced lung inflammation
Han, C. L., Ho, C.-C., Yang, C. S., Chang, W., Tsai, M., Tsai, H.-T., & Lin, P. (2013) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2013.01.001 · Cited by 55
Pike, K. A., Hutchins, A. P., Vinette, V., Théberge, J.-F., Sabbagh, L., Tremblay, M. L., & Miranda‐Saavedra, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005020 · Cited by 57
Stroma: the forgotten cells of innate immune memory
Crowley, T., Buckley, C. D., & Clark, A. R. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13149 · Cited by 55
Alexander, A. F., Kelsey, I., Forbes, H., & Miller‐Jensen, K. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.109728 · Cited by 55
Hulme, K. D., Noye, E. C., Short, K. R., & Labzin, L. I. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.770066 · Cited by 52
Agrawal, S., Gollapudi, S. V. S., Gupta, S., & Agrawal, A. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.006 · Cited by 47
O’Neil, J. D., Ross, E. A., Ridley, M. L., Ding, Q., Tang, T., Rosner, D. R., Crowley, T., Malhi, D., Dean, J. L. E., Smallie, T., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00536-16 · Cited by 46
CITED2 Restrains Proinflammatory Macrophage Activation and Response
Kim, G.-D., Das, R., Rao, X., Zhong, J., Deiuliis, J. A., Ramírez‐Bergeron, D. L., Rajagopalan, S., & Mahabeleshwar, G. H. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00452-17 · Cited by 45
Zhou, H., Gao, S., Duan, X., Liang, S., Scott, D. A., Lamont, R. J., & Wang, H. (2015) · The FASEB Journal · doi:10.1096/fj.15-270462 · Cited by 40
Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ1–42 in BV-2 cells
Zhang, Z., Wu, Z., Zhu, X., Hui, X.-C., Pan, J., & Xu, Y. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.01.005 · Cited by 40
Howes, A., Taubert, C., Blankley, S., Spink, N., Wu, X., Graham, C. M., Zhao, J., Saraiva, M., Ricciardi‐Castagnoli, P., Bancroft, G. J., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501923 · Cited by 41
Qiu, W., Wu, H., Hu, Z., Wu, X., Tu, M., Fang, F., Zhu, X., Liu, Y., Lian, J., Valverde, P., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15277 · Cited by 39
Gao, L., Yu, Q., Zhang, H., Wang, Z., Zhang, T., Xiang, J., Yu, S., Zhang, S., Wu, H., Xu, Y., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb5071 · Cited by 41
GHK and DNA: Resetting the human genome to health
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39
Hsu, K., Chung, Y. M., Endoh, Y., & Geczy, C. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103629 · Cited by 38
Immunopathology and immune homeostasis during viral infection in insects
González‐González, A., & Wayne, M. L. (2020) · Advances in virus research · doi:10.1016/bs.aivir.2020.06.001 · Cited by 35
Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism
Menzfeld, C., John, M., van Rossum, D., Regen, T., Scheffel, J., Jáňová, H., Götz, A. A., Ribes, S., Nau, R., Borisch, A., et al. (2015) · Glia · doi:10.1002/glia.22803 · Cited by 36
Tran, T. A. T., Grievink, H. W., Lipinska, K., Kluft, C., Burggraaf, J., Moerland, M., Tasev, D., & Malone, K. E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214999 · Cited by 37
Liu, J., Zhang, Z., Chai, L., Che, Y., Min, S., & Yang, R. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.03.071 · Cited by 34
Macrophage production and activation are dependent on TRIM33
Gallouët, A.-S., Ferri, F., Petit, V., Parcelier, A., Lewandowski, D., Gault, N., Barroca, V., Gras, S. L., Soler, É., Grosveld, F. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13872 · Cited by 37
Yang, D., Li, S., Duan, X., Ren, J., Liang, S., Yakoumatos, L., Kang, Y., Uriarte, S. M., Shang, J., Li, W., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.12.013 · Cited by 32
Clinical applications of oligonucleotides for cancer therapy
DeFranciscis, V., Amabile, G., & Kortylewski, M. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.02.045 · Cited by 35
Hedl, M., Sun, R., Huang, C. L., & Abraham, C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900031 · Cited by 30
Wei, J., Wei, C., Wang, M., Xiao, Q., Li, Y., Yuan, Y., Jin, C., Leng, L., Wang, J., Yang, X., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309218111 · Cited by 32
B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors
Zhao, X., Zhang, Z., Moreira, D., Su, Y., Won, H., Adamus, T., Dong, Z., Liang, Y., Yin, H. H., Swiderski, P. M., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.01.007 · Cited by 32
Coordinated Post-Transcriptional Regulation of the Chemokine System: Messages from CCL2
Panganiban, R. P., Vonakis, B. M., Ishmael, F. T., & Stellato, C. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0149 · Cited by 32
Hutchins, A. P., Diez, D., & Miranda-Saavedra, D. (2013) · JAK-STAT · doi:10.4161/jkst.25097 · Cited by 31
Neaga, A., Bagacean, C., Tempescul, A., Jimbu, L., Mesaros, O., Blag, C., Tomuleasa, C., Bocsan, C., Gaman, M., & Zdrenghea, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582915 · Cited by 30
Ha, S.-D., Reid, C., Meshkibaf, S., & Kim, S. O. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.695809 · Cited by 30
Epigenetic Regulation of Myeloid Cells
Ivashkiv, L. B., & Park, S. H. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0010-2015 · Cited by 27
Han, X., Ren, J., Lohner, H., Yakoumatos, L., Liang, R., & Wang, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102036 · Cited by 29
DietaryArtemisia ordosicaextract alleviating immune stress in broilers exposed to lipopolysaccharide
Li, K., Zhang, P., Shi, B., Su, J., Yue, Y., Tong, M., & Yan, S. (2017) · Italian Journal of Animal Science · doi:10.1080/1828051x.2016.1274242 · Cited by 28
Suppressor of Cytokine Signaling 3 (SOCS3) Degrades p65 and Regulate HIV-1 Replication
Sood, V., Lata, S., Ramachandran, V. G., & Banerjea, A. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00114 · Cited by 26
MTDH Promotes Intestinal Inflammation by Positively Regulating TLR Signalling
Wang, L., Zhang, N., Han, D., Su, P., Chen, B., Zhao, W., Liu, Y., Zhang, H., Hu, G., & Yang, Q. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab086 · Cited by 26
MicroRNAs as Regulators of Phagocytosis
Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25
Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia
Amantea, D., Petrelli, F., Greco, R., Tassorelli, C., Corasaniti, M. T., Tonin, P., & Bagetta, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01256 · Cited by 25
Günthner, R., Kumar, V., Lorenz, G., Anders, H., & Lech, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918124 · Cited by 24
Niedzielska, M., Bodendorfer, B., Münch, S., Eichner, A., Derigs, M., da Costa, O., Schweizer, A., Neff, F., Nitschke, L., Sparwasser, T. D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.535245 · Cited by 24
Buchwald, Z. S., & Aurora, R. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/429373 · Cited by 24
Issues with the Specificity of Immunological Reagents for Murine IDO1
de Velde, L.-A. V., Gingras, S., Pelletier, S. W., & Murray, P. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.004 · Cited by 24
Self-citationLi, Z., Trakooljul, N., Hadlich, F., Ponsuksili, S., Wimmers, K., & Muráni, E. (2021) · Virulence · doi:10.1080/21505594.2021.1948276 · Cited by 22
Yang, Z., Yang, J., Zhu, P. J., Han, H. M., Wan, X., Yang, H., & Wang, Z. Y. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102153 · Cited by 22
Lü, L., Yakoumatos, L., Ren, J., Duan, X., Zhou, H., Gu, Z., Mohammed, M., Uriarte, S. M., Liang, S., Scott, D. A., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902697rr · Cited by 21
Quinn, K. M., Yamamoto, A., Costa, A. D. S., Darrah, P. A., Lindsay, R. W. B., Hegde, S. T., Johnson, T. R., Flynn, B. J., Loré, K., & Seder, R. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301730 · Cited by 21
Wu, X., Zhang, G., Wang, X., Zhang, P., & Tan, Y. (2014) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2014.10.005 · Cited by 20
The Genetics of Innate Immunity Sensors and Human Disease
Pothlichet, J., & Quintana‐Murci, L. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.777064 · Cited by 20
Zhi, S., Wang, J., Wang, Y., Yang, L., Qin, C., Yan, X., Zhao, M., Liu, M., Qu, L., & Nie, G. (2023) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2023.108859 · Cited by 19
Metadata
- Authors
- Murray, P. J., & Smale, S. T.
- Affiliations
- St. Jude Children's Research Hospital (US)
- University of California, Los Angeles (US)
- Corresponding author
- Murray, Peter J
- ORCID
- Murray, Peter J
- Venue
- Nature Immunology
- Published
- 2012-09-18
- Volume
- 13
- Issue
- 10
- Pages
- 916-924
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC4893774
- OpenAlex
- W2006283298
- Cited by
- 170
- References
- 120
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 4 · 2023: 5 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 17 · 2015: 19 · 2014: 19 · 2013: 24 · 2012: 4
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Hartwell Foundation
- National Cancer Institute (P 30CA 21765, R01CA127279, P30CA021765)
- National Institute of General Medical Sciences (R01GM086372)
- National Institute of Allergy and Infectious Diseases (R01AI073868)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- Toll-like receptor signaling, anti-inflammatory pathways, negative regulation of inflammation, inflammatory signaling, host defense, tissue damage, tissue repair, innate immunity, adaptive immunity, microbial products
- MeSH terms
- Animals, Humans, Inflammation, Lipopolysaccharides, Transcription, Genetic, Wound Healing, Signal Transduction, Interleukin-10, Toll-Like Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review