The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways
Open accessAbstract
Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of excessive inflammation is cell and tissue damage, an underlying cause of many acute and chronic diseases. Coincident with activation of TLR signaling, a plethora of anti-inflammatory pathways and mechanisms begin to modulate inflammation until tissue repair is complete. Whereas most studies have focused on the signaling components immediately downstream of the TLRs, this Review summarizes the different levels of anti-inflammatory pathways that have evolved to abate TLR signaling and how they are integrated to prevent cell and tissue destruction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Expression of the M1 phenotype is regulated by transcription factors such as NF-κB, IRF-3, and IRF-5 [189,190,191].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [189]
Experimental — accuracy not yet measuredIn the citing paper
“The treatment of rats, mice, and pigs with GHK was shown to effectively activate systemic healing throughout the animal.”
From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Self-citationInterleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
The regulation of IL-10 production by immune cells
Saraiva, M., & O’Garra, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2711 · Cited by 3,293
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,064
Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
The IL-1 family: regulators of immunity
Sims, J. E., & Smith, D. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2691 · Cited by 1,459
Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409
Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367
Gene-specific control of inflammation by TLR-induced chromatin modifications
Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344
Endotoxin tolerance: new mechanisms, molecules and clinical significance
Biswas, S. K., & Lopez-Collazo, E. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.009 · Cited by 1,318
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
Kobayashi, K. S., Hernandez, L. D., Galán, J. E., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00827-9 · Cited by 1,310
Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation
Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood · doi:10.1182/blood-2009-10-249540 · Cited by 1,246
Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220
The JAK-STAT Signaling Pathway: Input and Output Integration
Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2623 · Cited by 1,179
Self-citationImmunomodulatory functions of type I interferons
González-Navajas, J. M., Lee, J., David, M., & Raz, E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3133 · Cited by 1,030
Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4
Colotta, F., Re, F., Muzio, M., Bertini, R., Polentarutti, N., Sironi, M., Giri, J. G., Dower, S., Sims, J. E., & Mantovani, A. (1993) · Science · doi:10.1126/science.8332913 · Cited by 979
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Häcker, G. A., et al. (2005) · Nature · doi:10.1038/nature04369 · Cited by 962
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zarnegar, B. J., Perry, A. K., & Cheng, G. (2005) · Nature · doi:10.1038/nature04374 · Cited by 881
microRNA Regulation of Inflammatory Responses
O'Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 843
Cytokine Signaling Modules in Inflammatory Responses
O’Shea, J. J., & Murray, P. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.002 · Cited by 833
Self-citationAntigen-presenting cell function in the tolerogenic liver environment
Thomson, A. W., & Knolle, P. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2858 · Cited by 830
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
Gilchrist, M., Thórsson, V., Li, B., Rust, A. G., Korb, M., Kennedy, K., Hai, T., Bolouri, H., & Aderem, A. A. (2006) · Nature · doi:10.1038/nature04768 · Cited by 810
Alexander, W. S., & Hilton, D. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.091003.090312 · Cited by 710
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.029 · Cited by 647
SOCS-1 Participates in Negative Regulation of LPS Responses
Nakagawa, R., Naka, T., Tsutsui, H., Fujimoto, M., Kimura, A., Abe, T., Seki, E., Sato, S., Takeuchi, O., Takeda, K., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00449-1 · Cited by 644
SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation
Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., & Yoshimura, A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00446-6 · Cited by 630
Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10
Lang, R., Patel, D. H., Morris, J. J., Rutschman, R., & Murray, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2253 · Cited by 621
Self-citationAchieving Stability of Lipopolysaccharide-Induced NF-κB Activation
Covert, M. W., Leung, T., Gaston, J. E., & Baltimore, D. (2005) · Science · doi:10.1126/science.1112304 · Cited by 612
SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling
Wald, D. N., Qin, J., Zhao, Z., Qian, Y., Naramura, M., Tian, L., Towne, J. E., Sims, J. E., Stark, G. R., & Li, X. (2003) · Nature Immunology · doi:10.1038/ni968 · Cited by 606
Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip
Zhang, G., & Ghosh, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109537200 · Cited by 598
Ramirez-Carrozzi, V. R., Braas, D., Bhatt, D. M., Cheng, C. S., Hong, C., Doty, K. R., Black, J. C., Hoffmann, A., Carey, M., & Smale, S. T. (2009) · Journal of End-to-End-testing · doi:10.1016/j.cell.2009.04.020 · Cited by 595
Self-citationChi, H., Barry, S. P., Flach, R. J. R., Wu, J. J., Jones, E. A., Bennett, A. M., & Flavell, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510965103 · Cited by 568
PI3K-mediated negative feedback regulation of IL-12 production in DCs
Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T., & Koyasu, S. (2002) · Nature Immunology · doi:10.1038/ni825 · Cited by 535
Mansell, A. S., Smith, R., Doyle, S., Gray, P., Fenner, J. E., Crack, P. J., Nicholson, S. E., Hilton, D. J., O'Neill, L. A. J., & Hertzog, P. J. (2006) · Nature Immunology · doi:10.1038/ni1299 · Cited by 517
Stimulus Specificity of Gene Expression Programs Determined by Temporal Control of IKK Activity
Werner, S. L., Barken, D. M., & Hoffmann, A. (2005) · Science · doi:10.1126/science.1113319 · Cited by 509
Interactions between coagulation and complement—their role in inflammation
Οικονομοπούλου, Κ., Ricklin, D., Ward, P. A., & Lambris, J. D. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0280-x · Cited by 489
The role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O’Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 480
Self-citationThe human Mi-2/NuRD complex and gene regulation
Denslow, S. A., & Wade, P. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210611 · Cited by 479
Metabolic checkpoints in activated T cells
Wang, R., & Green, D. R. (2012) · Nature Immunology · doi:10.1038/ni.2386 · Cited by 477
Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 466
Han, C., Jin, J., Xu, S., Liu, H., Li, N., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1908 · Cited by 465
Accessory molecules for Toll-like receptors and their function
Lee, C. C., Avalos, A. M., & Ploegh, H. L. (2012) · Nature reviews. Immunology · doi:10.1038/nri3151 · Cited by 453
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
McAuley, J., Lindén, S. K., Png, C. W., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V., & McGuckin, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26705 · Cited by 437
Innate Response Activator B Cells Protect Against Microbial Sepsis
Rauch, P. J., Chudnovskiy, A., Robbins, C. S., Weber, G. F., Etzrodt, M., Hilgendorf, I., Tiglao, E., Figueiredo, J., Iwamoto, Y., Theurl, I., et al. (2012) · Science · doi:10.1126/science.1215173 · Cited by 425
Ramirez-Carrozzi, V. R., Nazarian, A. A., Li, C. C., Gore, S. L., Sridharan, R., Imbalzano, A. N., & Smale, S. T. (2006) · Genes & Development · doi:10.1101/gad.1383206 · Cited by 422
Self-citationReflex principles of immunological homeostasis
Andersson, U., & Tracey, K. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075015 · Cited by 414
Negative regulation of Toll-like-receptor signaling by IRF-4
Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T., & Honda, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508327102 · Cited by 412
Murray, P. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500419102 · Cited by 395
Self-citationNegative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
Divanovic, S., Trompette, A., Atabani, S. F., Madan, R., Golenbock, D. T., Visintin, A., Finberg, R. W., Tarakhovsky, A., Vogel, S. N., Belkaid, Y., et al. (2005) · Nature Immunology · doi:10.1038/ni1198 · Cited by 381
Casanova, J., Abel, L., & Quintana‐Murci, L. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101335 · Cited by 377
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
Zhao, Q., Wang, X., Nelin, L. D., Yao, Y., Matta, R., Manson, M. E., Baliga, R. S., Meng, X., Smith, C. V., Bauer, J. A., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051794 · Cited by 370
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.010 · Cited by 354
Return to homeostasis: downregulation of NF-κB responses
Ruland, J. (2011) · Nature Immunology · doi:10.1038/ni.2055 · Cited by 329
Hammer, M., Mages, J., Dietrich, H., Servatius, A., Howells, N., Cato, A. C. B., & Lang, R. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051753 · Cited by 327
Selective Transcription in Response to an Inflammatory Stimulus
Smale, S. T. (2010) · Cell · doi:10.1016/j.cell.2010.01.037 · Cited by 326
Self-citationThe kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
Ananieva, O., Darragh, J., Johansen, C., Carr, J. M., McIlrath, J. M., Park, J. M., Wingate, A. D., Monk, C. E., Toth, R. L., Santos, S. G., et al. (2008) · Nature Immunology · doi:10.1038/ni.1644 · Cited by 325
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
Hamerman, J. A., Tchao, N. K., Lowell, C. A., & Lanier, L. L. (2005) · Nature Immunology · doi:10.1038/ni1204 · Cited by 325
Schroder, K., Irvine, K. M., Taylor, M. S., Bokil, N. J., Cao, K. L., Masterman, K., Labzin, L. I., Semple, C. A. M., Kapétanovic, R., Fairbairn, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110156109 · Cited by 317
Hu, X., Chakravarty, S. D., & Ivashkiv, L. B. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00707.x · Cited by 303
Beyond pattern recognition: five immune checkpoints for scaling the microbial threat
Blander, J. M., & Sander, L. E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3167 · Cited by 300
Woo, C. W., Cui, D., Arellano, J., Dorweiler, B., Harding, H. P., Fitzgerald, K. A., Ron, D., & Tabas, I. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1996 · Cited by 289
Crosstalk pathways between Toll-like receptors and the complement system
Hajishengallis, G., & Lambris, J. D. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.01.002 · Cited by 280
Baetz, A., Frey, M., Heeg, K. M., & Dalpke, A. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410992200 · Cited by 273
NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance
Liu, T. F., Yoza, B. K., Gazzar, M. E., Vachharajani, V., & McCall, C. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.196790 · Cited by 270
Ashida, H., Kim, M., Schmidt‐Supprian, M., Ma, A. I., Ogawa, M., & Sasakawa, C. (2009) · Nature Cell Biology · doi:10.1038/ncb2006 · Cited by 264
Bcl-6 and NF-κB cistromes mediate opposing regulation of the innate immune responsePreprint
Barish, G. D., Yu, R. T., Karunasiri, M. S., Ocampo, C. B., Dixon, J. R., Benner, C. W., Dent, A. L., Tangirala, R. K., & Evans, R. M. (2010) · Genes & Development · doi:10.1101/gad.1998010 · Cited by 258
Post-transcriptional regulons coordinate the initiation and resolution of inflammation
Anderson, P. (2010) · Nature Reviews Immunology · doi:10.1038/nri2685 · Cited by 257
IL-10 Inhibits miR-155 Induction by Toll-like Receptors
McCoy, C. E., Sheedy, F. J., Qualls, J. E., Doyle, S., Quinn, S. R., Murray, P. J., & O'Neill, L. A. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102111 · Cited by 256
Self-citationImmune dysregulation in TGF- beta 1-deficient mice.
Christ, M., McCartney-Francis, N. L., Kulkarni, A. B., Ward, J. M., Mizel, D. E., Mackall, C. L., Gress, R. E., Hines, K. L., Tian, H., Karlsson, S., et al. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.1936 · Cited by 229
Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens
Cyktor, J. C., & Turner, J. (2011) · Infection and Immunity · doi:10.1128/iai.00047-11 · Cited by 227
General nature of the STAT3-activated anti-inflammatory response.
El Kasmi, K. C., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A. M., Rutschman, R., Kaushal, D., Shen, Y., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7880 · Cited by 225
Self-citationAgammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K
Conley, M. E., Dobbs, K., Quintana, A. M., Bosompem, A., Wang, Y., Coustan‐Smith, E., Smith, A. M., Pérez, E., & Murray, P. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112533 · Cited by 222
Self-citationCross-regulation of signaling by ITAM-associated receptors
Ivashkiv, L. B. (2009) · Nature Immunology · doi:10.1038/ni.1706 · Cited by 219
Negative Regulation of TLR-Signaling Pathways by Activating Transcription Factor-3
Whitmore, M., Iparraguirre, A., Kubelka, L., Weninger, W., Hai, T., & Williams, B. R. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3622 · Cited by 215
Gene-specific control of the TLR-induced inflammatory response
Foster, S. L., & Medzhitov, R. M. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.08.015 · Cited by 213
Phillips, K., Kedersha, N., Shen, L., Blackshear, P. J., & Anderson, P. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400148101 · Cited by 199
Human genetics of infectious diseases: between proof of principle and paradigm
Alcaïs, A., Abel, L., & Casanova, J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38111 · Cited by 190
Tumor necrosis factor induces GSK3 kinase–mediated cross-tolerance to endotoxin in macrophages
Park, S. H., Park‐Min, K., Chen, J., Hu, X., & Ivashkiv, L. B. (2011) · Nature Immunology · doi:10.1038/ni.2043 · Cited by 183
El Kasmi, K. C., Smith, A. M., Williams, L., Neale, G., Panopolous, A., Watowich, S. S., Häcker, H., Foxwell, B. M. J., & Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7215 · Cited by 182
Self-citationLiang, S., Krauss, J. L., Domon, H., McIntosh, M. L., Hosur, K. B., Qu, H., Li, F., Τζέκου, Α., Lambris, J. D., & Hajishengallis, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1003252 · Cited by 177
MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling
Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H., & Kim, K. C. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0336rc · Cited by 172
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
Oshima, S., Turer, E. E., Callahan, J. A., Chai, S., Advincula, R., Barrera, J., Shifrin, N. T., Lee, B. L., Yen, B. C., Woo, T. T., et al. (2008) · Nature · doi:10.1038/nature07575 · Cited by 169
Ivashkiv, L. B. (2011) · European Journal of Immunology · doi:10.1002/eji.201141783 · Cited by 162
TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils
Alagbala, A. A., Wang, Q., Cui, J., Zou, J., Xia, X., Wang, M., Tong, Y., Hui, W., Liu, D., Su, B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.010 · Cited by 160
IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling
Chen, J., & Ivashkiv, L. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007816107 · Cited by 160
Gingras, S., Parganas, E., Pauw, A. D., Ihle, J. N., & Murray, P. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411043200 · Cited by 148
Self-citationRegulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum
Martinon, F., & Glimcher, L. H. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.016 · Cited by 144
Liang, J., Jiang, D., Griffith, J. W., Yu, S., Fan, J., Zhao, X., Bucala, R., & Noble, P. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2469 · Cited by 139
Wilson, M. S., Elnekave, E., Mentink-Kane, M. M., Hodges, M. G., Pesce, J. T., Ramalingam, T. R., Thompson, R. W., Kamanaka, M., Flavell, R. A., Keane-Myers, A., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31546 · Cited by 137
Hutchins, A. P., Poulain, S., & Miranda‐Saavedra, D. (2012) · Blood · doi:10.1182/blood-2011-09-381483 · Cited by 134
Yiakouvaki, A., Dimitriou, M., Karakasiliοtis, I., Eftychi, C., Theocharis, S., & Kontoyiannis, D. L. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45021 · Cited by 124
Kapétanovic, R., Fairbairn, L., Beraldi, D., Sester, D. P., Archibald, A. L., Tuggle, C. K., & Hume, D. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102649 · Cited by 123
NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity
Kobayashi, T., Matsuoka, K., Sheikh, S. Z., Elloumi, H. Z., Kamada, N., Hisamatsu, T., Hansen, J. J., Doty, K. R., Pope, S. D., Smale, S. T., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003888 · Cited by 122
Self-citationAutophagy in regulation of Toll-like receptor signaling
Into, T., Inomata, M., Takayama, E., & Takigawa, T. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.020 · Cited by 121
Cytokines, virokines and the evolution of immunity
Dower, S. (2000) · Nature Immunology · doi:10.1038/80799 · Cited by 120
IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages
Smallie, T., Ricchetti, G., Horwood, N. J., Feldmann, M., Clark, A. R., & Williams, L. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100414 · Cited by 115
Zhou, J., Wu, R., High, A. A., Slaughter, C. A., Finkelstein, D., Rehg, J. E., Redecke, V., & Häcker, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106232108 · Cited by 112
Zhou, L., Nazarian, A. A., & Smale, S. T. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2385-2396.2004 · Cited by 111
Self-citationTristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation
Kratochvill, F., Machacek, C., Vogl, C., Ebner, F., Sedlyarov, V., Gruber, A. R., Hartweger, H., Vielnascher, R. M., Karaghiosoff, M., Rülicke, T., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.93 · Cited by 111
Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes
Colotta, F., Saccani, S., Giri, J. G., Dower, S., Sims, J. E., Introna, M., & Mantovani, A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.7.2534 · Cited by 108
Role of transcriptional coregulator GRIP1 in the anti-inflammatory actions of glucocorticoids
Chinenov, Y. V., Gupte, R., Dobrovolná, J., Flammer, J. R., Liu, B., Michelassi, F. E., & Rogatsky, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206059109 · Cited by 106
Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-10
Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Müller, M. M., Blackshear, P. J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803883 · Cited by 102
Self-citationMarteyn, B., Gazi, A. D., & Sansonetti, P. J. (2012) · Gut Microbes · doi:10.4161/gmic.19325 · Cited by 101
Integration of cytokine and heterologous receptor signaling pathways
Bezbradica, J. S., & Medzhitov, R. M. (2009) · Nature Immunology · doi:10.1038/ni.1713 · Cited by 97
Tumor suppressor CYLD: negative regulation of NF-κB signaling and more
Courtois, G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7465-4 · Cited by 81
Biswas, A., Wilmanski, J., Forsman, H. F., Hrnčíř, T., Hao, L., Tlaskalová-Hogenová, H., & Kobayashi, K. S. (2010) · European Journal of Immunology · doi:10.1002/eji.201040479 · Cited by 78
Smith, A. M., Qualls, J. E., O’Brien, K., Balouzian, L., Johnson, P. F., Schultz‐Cherry, S., Smale, S. T., & Murray, P. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.249235 · Cited by 78
Self-citationInterpreting mixed signals: the cell's cytokine conundrum
Delgoffe, G. M., Murray, P. J., & Vignali, D. A. A. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.013 · Cited by 69
Self-citationYanada, M., Kojima, T., Ishiguro, K., Nakayama, Y., Yamamoto, K., Matsushita, T., Kadomatsu, K., Nishimura, M., Muramatsu, T., & Saito, H. (2002) · Blood · doi:10.1182/blood.v99.7.2455 · Cited by 56
An Inducible Enhancer Required forIl12bPromoter Activity in an Insulated Chromatin Environment
Zhou, L., Nazarian, A. A., Xu, J., Tantin, D. R., Corcoran, L. M., & Smale, S. T. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00788-06 · Cited by 48
Self-citationMARCKS as a Negative Regulator of Lipopolysaccharide Signaling
Manček‐Keber, M., Benčina, M., Japelj, B., Panter, G., Andrä, J., Brandenburg, K., Triantafilou, M., Triantafilou, K., & Jerala, R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1003605 · Cited by 24
Flagged first, then by citations
1 of the 120 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Regulation of pattern recognition receptor signalling in plants
Couto, D., & Zipfel, C. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.77 · Cited by 1,400
A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes
Carpenter, S. B., Aiello, D. A., Atianand, M., Ricci, E. P., Gandhi, P., Hall, L. L., Byron, M., Monks, B. G., Henry-Bezy, M., Lawrence, J. B., et al. (2013) · Science · doi:10.1126/science.1240925 · Cited by 957
Wu, J.-Y., Huang, T., Hsieh, Y.-T., Wang, Y., Yen, C.-C., Lee, G.-L., Yeh, C., Peng, Y., Kuo, Y.-Y., Wen, H.-T., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.023 · Cited by 549
Toll-like receptors: Activation, signalling and transcriptional modulation
Nardo, D. D. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.025 · Cited by 484
The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges
Hutchins, A. P., Díez, D., & Miranda‐Saavedra, D. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt028 · Cited by 435
Metadata
- Authors
- Murray, P. J., & Smale, S. T.
- Affiliations
- St. Jude Children's Research Hospital (US)
- University of California, Los Angeles (US)
- Corresponding author
- Murray, Peter J
- ORCID
- Murray, Peter J
- Venue
- Nature Immunology
- Published
- 2012-09-18
- Volume
- 13
- Issue
- 10
- Pages
- 916-924
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC4893774
- OpenAlex
- W2006283298
- Cited by
- 170
- References
- 120
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 4 · 2023: 5 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 17 · 2015: 19 · 2014: 19 · 2013: 24 · 2012: 4
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Hartwell Foundation
- National Cancer Institute (P 30CA 21765, R01CA127279, P30CA021765)
- National Institute of General Medical Sciences (R01GM086372)
- National Institute of Allergy and Infectious Diseases (R01AI073868)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- Toll-like receptor signaling, anti-inflammatory pathways, negative regulation of inflammation, inflammatory signaling, host defense, tissue damage, tissue repair, innate immunity, adaptive immunity, microbial products
- MeSH terms
- Animals, Humans, Inflammation, Lipopolysaccharides, Transcription, Genetic, Wound Healing, Signal Transduction, Interleukin-10, Toll-Like Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review