The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Immune cell migration in inflammation: present and future therapeutic targets
Abstract
The burgeoning field of leukocyte trafficking has created new and exciting opportunities in the clinic. Trafficking signals are being defined that finely control the movement of distinct subsets of immune cells into and out of specific tissues. Because the accumulation of leukocytes in tissues contributes to a wide variety of diseases, these 'molecular codes' have provided new targets for inhibiting tissue-specific inflammation, which have been confirmed in the clinic. However, immune cell migration is also critically important for the delivery of protective immune responses to tissues. Thus, the challenge for the future will be to identify the trafficking molecules that will most specifically inhibit the key subsets of cells that drive disease processes without affecting the migration and function of leukocytes required for protective immunity.
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“but also the mononuclear cells during tethering and rolling over the BBB in the early phase of neuroinflammation detected in MS and related disorders [169].”
From GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review (2022) · cites this paper as [169]
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Cites
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Identification of splenic reservoir monocytes and their deployment to inflammatory sites
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A cytokine-mediated link between innate immunity, inflammation, and cancer
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Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724
Metadata
- Authors
- Luster, A. D., Alon, R., & von Andrian, U. H.
- Affiliations
- Harvard University (US)
- Weizmann Institute of Science (IL)
- Corresponding author
- Luster, Andrew D
- Alon, Ronen
- Venue
- Nature Immunology
- Published
- 2005-11-17
- Volume
- 6
- Issue
- 12
- Pages
- 1182-1190
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2002148098
- Semantic Scholar
- 325fe5881ea7ce80fed07b71dbe54da5201a96c6
- Cited by
- 1,313
- References
- 97
- Citations by year
- 2026: 21 · 2025: 64 · 2024: 66 · 2023: 70 · 2022: 53 · 2021: 49 · 2020: 44 · 2019: 46 · 2018: 48 · 2017: 69 · 2016: 66 · 2015: 60 · 2014: 75 · 2013: 73 · 2012: 75
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dana Foundation
- Roche Organ Transplant Research Foundation
- Israel Science Foundation
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- leukocyte migration, inflammation, chemokines, chemokine receptors, tissue-specific inflammation, therapeutic target, protective immunity, leukocyte homing
- MeSH terms
- Animals, Cell Movement, Humans, Immunotherapy, Inflammation
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