Immune cell migration in inflammation: present and future therapeutic targets

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009

Immunobiology of Dendritic Cells

Banchereau, J., Brière, F., Caux, C., Davoust, J. M., Lebecque, S., Liu, Y., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,755

Chemokines — Chemotactic Cytokines That Mediate Inflammation

Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

Butcher, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90279-8 · Cited by 2,789

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.

Jung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

Sallusto, F., Lenig, D., Mackay, C. R., & Lanzavecchia, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.875 · Cited by 1,535

T-Cell Function and Migration — Two Sides of the Same Coin

von Andrian, U. H., & Mackay, C. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431407 · Cited by 1,429

A controlled trial of natalizumab for relapsing multiple sclerosis.

Miller, D. H., Khan, O., Sheremata, W., Blumhardt, L., Rice, G., Libonati, M., Willmer-Hulme, A., Dalton, C., Miszkiel, K., & O'Connor, P. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020696 · Cited by 1,265

C hemokines in I nnate and A daptive H ost D efense : Basic Chemokinese Grammar for Immune Cells

Rot, A., & von Andrian, U. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104543 · Cited by 1,209

Extracellular matrix remodelling: the role of matrix metalloproteinases

Stamenkovic, I. (2003) · The Journal of Pathology · doi:10.1002/path.1400 · Cited by 1,174

Essential involvement of interleukin-8 (IL-8) in acute inflammation

Harada, A., Sekido, N., Akahoshi, T., Wada, T., Mukaida, N., & Matsushima, K. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.559 · Cited by 1,041

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E

Huo, Y., Schober, A., Forlow, S. B., Smith, D. F., Hyman, M. C., Jung, S., Littman, D. R., Weber, C., & Ley, K. F. (2002) · Nature Medicine · doi:10.1038/nm810 · Cited by 1,026

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

Berlin, C., Bargatze, R. F., Campbell, J. J., von Andrian, U. H., Szabo, M. C., Hasslen, S. R., Nelson, R. D., Berg, E. L., Erlandsen, S. L., & Butcher, E. C. (1995) · Cell · doi:10.1016/0092-8674(95)90491-3 · Cited by 1,002

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

Cyster, J. G. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115628 · Cited by 856

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

Müller, W. A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00117-0 · Cited by 824

Natalizumab for Active Crohn's Disease

Ghosh, S. K., Goldin, E., Gordon, F. H., Malchow, H. A., Rask-Madsen, J., Rutgeerts, P. J., Vyhnálek, P., Zádorová, Z., Palmer, T., & Donoghue, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020732 · Cited by 811

Ligands for L-Selectin: Homing, Inflammation, and Beyond

Rosen, S. D. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.090501.080131 · Cited by 786

P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

Austrup, F., Vestweber, D., Borges, E., Löhning, M., Bräuer, R., Herz, U., Renz, H. E., Hallmann, R., Scheffold, A., Radbruch, A., et al. (1997) · Nature · doi:10.1038/385081a0 · Cited by 723

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

Rosen, H., & Goetzl, E. J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1650 · Cited by 702

Treatment of Ulcerative Colitis with a Humanized Antibody to the α 4 β 7 Integrin

Feagan, B. G., Greenberg, G. R., Wild, G., Fedorak, R. N., Paré, P., McDonald, J. W., Dubé, R., Cohen, A., Steinhart, A. H., Landau, S. B., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042982 · Cited by 693

A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

Carman, C. V., & Springer, T. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404129 · Cited by 682

Macromolecular organization of basement membranes

Timpl, R. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80102-5 · Cited by 665

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

Kunkel, E. J., Campbell, J. J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A. I., Ebert, E. C., Vierra, M. A., Goodman, S. B., Genovese, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.761 · Cited by 637

RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium

von Hundelshausen, P., Weber, K. S. C., Huo, Y., Proudfoot, A. E. I., Nelson, P. J., Ley, K. F., & Weber, C. (2001) · Circulation · doi:10.1161/01.cir.103.13.1772 · Cited by 597

Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes

Barreiro, O., Yáñez‐Mó, M., Serrador, J. M., Montoya, M. C., Vicente‐Manzanares, M., Tejedor, R., Furthmayr, H., & Sánchez‐Madrid, F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200112126 · Cited by 594

Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

Ancuța, P., Rao, R., Moses, A. V., Mehle, A., Shaw, S. K., Luscinskas, F. W., & Gabuzda, D. H. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20022156 · Cited by 591

Integrin cytoplasmic domain-binding proteins

Liu, S., Calderwood, D., & Ginsberg, M. H. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.20.3563 · Cited by 573

Intracellular signalling controlling integrin activation in lymphocytes

Kinashi, T. (2005) · Nature reviews. Immunology · doi:10.1038/nri1646 · Cited by 555

Plasma-cell homing

Kunkel, E. J., & Butcher, E. C. (2003) · Nature reviews. Immunology · doi:10.1038/nri1203 · Cited by 537

CC Chemokine Receptor (CCR)4 and the CCR10 Ligand Cutaneous T Cell–attracting Chemokine (CTACK) in Lymphocyte Trafficking to Inflamed Skin

Reiss, Y., Proudfoot, A. E. I., Power, C., Campbell, J. J., & Butcher, E. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1541 · Cited by 516

Migratory properties of naive, effector, and memory CD8(+) T cells

Weninger, W., Crowley, M. A., Manjunath, N., & von Andrian, U. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.953 · Cited by 515

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

Sekido, N., Mukaida, N., Harada, A., Nakanishi, I., Watanabe, Y., & Matsushima, K. (1993) · Nature · doi:10.1038/365654a0 · Cited by 514

Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

Bromley, S. K., Thomas, S. Y., & Luster, A. D. (2005) · Nature Immunology · doi:10.1038/ni1240 · Cited by 509

Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood–Brain Barrier in Experimental Autoimmune Encephalomyelitis

Sixt, M., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., & Sorokin, L. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.933 · Cited by 504

Integrin avidity regulation: are changes in affinity and conformation underemphasized?

Carman, C. V., & Springer, T. A. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.08.003 · Cited by 500

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

Cook, D. N., Prosser, D. M., Förster, R., Zhang, J., Kuklin, N. A., Abbondanzo, S. J., Niu, X., Chen, S., Manfra, D. J., Wiekowski, M., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80201-0 · Cited by 497

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

Debes, G. F., Arnold, C. N., Young, A. J., Krautwald, S., Lipp, M., Hay, J. B., & Butcher, E. C. (2005) · Nature Immunology · doi:10.1038/ni1238 · Cited by 484

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases

Wolf, K., Müller, R., Borgmann, S., Bröcker, E., & Friedl, P. (2003) · Blood · doi:10.1182/blood-2002-12-3791 · Cited by 442

Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment

Tager, A. M., Bromley, S. K., Medoff, B. D., Islam, S. A., Bercury, S. D., Friedrich, E. B., Carafone, A. D., Gerszten, R. E., & Luster, A. D. (2003) · Nature Immunology · doi:10.1038/ni970 · Cited by 415

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

Reedquist, K. A., Ross, E. A., Koop, E. A., Wolthuis, R. M. F., Zwartkruis, F. J. T., van Kooyk, Y., Salmon, M., Buckley, C. D., & Bos, J. L. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.6.1151 · Cited by 415

Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses

Wang, L., Fuster, M., Sriramarao, P., & Esko, J. D. (2005) · Nature Immunology · doi:10.1038/ni1233 · Cited by 413

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

Feng, D., Nagy, J. A., Pyne, K., Dvorak, H. F., & Dvořàk, A. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.903 · Cited by 412

Selectins: lectins that initiate cell adhesion under flow

McEver, R. P. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00367-8 · Cited by 411

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

Shamri, R., Grabovsky, V., Gauguet, J.-M., Feigelson, S. W., Manevich, E., Kolanus, W., Robinson, M. K., Staunton, D. E., von Andrian, U. H., & Alon, R. (2005) · Nature Immunology · doi:10.1038/ni1194 · Cited by 409

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

Humbles, A. A., Lu, B., Friend, D. S., Okinaga, S., Lora, J. M., Al-Garawi, A. A., Martin, T. R., Gerard, N. P., & Gerard, C. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261462598 · Cited by 390

Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.

Weber, C., & Springer, T. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119742 · Cited by 382

Role of the cytoskeleton during leukocyte responses

Vicente‐Manzanares, M., & Sánchez‐Madrid, F. (2004) · Nature reviews. Immunology · doi:10.1038/nri1268 · Cited by 375

An Antagonist of Monocyte Chemoattractant Protein 1 (MCP-1) Inhibits Arthritis in the MRL-lpr Mouse Model

Gong, J.-H., Ratkay, L. G., Waterfield, J. D., & Clark‐Lewis, I. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.1.131 · Cited by 375

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

Shimonaka, M., Katagiri, K., Nakayama, T., Fujita, N., Tsuruo, T., Yoshie, O., & Kinashi, T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301133 · Cited by 358

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

Vajkoczy, P., Laschinger, M., & Engelhardt, B. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12440 · Cited by 357

Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease

Ulbrich, H. K., Eriksson, E. E., & Lindbom, L. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.10.004 · Cited by 354

Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues

Goodarzi, K., Goodarzi, M., Tager, A. M., Luster, A. D., & von Andrian, U. H. (2003) · Nature Immunology · doi:10.1038/ni972 · Cited by 348

Rapid leukocyte integrin activation by chemokines

Laudanna, C., Kim, J. Y., Constantin, G., & Butcher, E. C. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18604.x · Cited by 340

CCR7 Expression and Memory T Cell Diversity in Humans

Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J., Greenberg, H. B., Vierra, M. A., Goodman, S. B., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.877 · Cited by 335

The Collagen Binding α1β1 Integrin VLA-1 Regulates CD8 T Cell-Mediated Immune Protection against Heterologous Influenza Infection

Ray, S. J., Franki, S. N., Pierce, R. H., Dimitrova, S., Koteliansky, V., Sprague, A., Doherty, P. C., de Fougerolles, A. R., & Topham, D. J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00021-4 · Cited by 317

Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues

Mora, J. R., Cheng, G., Picarella, D., Briskin, M., Buchanan, N. M., & von Andrian, U. H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041645 · Cited by 309

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

Ma, W., Bryce, P. J., Humbles, A. A., Laouini, D., Yalçindağ, A., Alenius, H. T., Friend, D. S., Oettgen, H. C., Gerard, C. J., & Geha, R. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14097 · Cited by 275

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.

Romanic, A. M., & Madri, J. A. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.5.1165 · Cited by 244

Integration of inflammatory signals by rolling neutrophils

Ley, K. F. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18602.x · Cited by 242

P-selectin Glycoprotein Ligand-1 Mediates L-Selectin–dependent Leukocyte Rolling in Venules

Sperandio, M., Smith, M. L., Forlow, S. B., Olson, T. S., Xia, L., McEver, R. P., & Ley, K. F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021854 · Cited by 238

Homing Phenotypes of Tumor-Specific CD8 T Cells Are Predetermined at the Tumor Site by Crosspresenting APCs

Calzascia, T., Masson, F., Berardino-Besson, W. D., Contassot, E., Wilmotte, R., Aurrand‐Lions, M., Rüegg, C., Dietrich, P., & Walker, P. R. (2005) · Immunity · doi:10.1016/j.immuni.2004.12.008 · Cited by 235

Lymphoid neogenesis:de novoformation of lymphoid tissue in chronic inflammation through expression of homing chemokines

Hjelmström, P. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.3.331 · Cited by 235

PECAM-1 (CD31) Homophilic Interaction Up-Regulates α6β1 on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of α6 Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane

Dangerfield, J. A., Larbi, K. Y., Huang, M., Dewar, A. L., & Nourshargh, S. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020324 · Cited by 234

The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2

Kim, M., Carman, C. V., Yang, W. Y., Salas, A., & Springer, T. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404160 · Cited by 227

L-Selectin Shedding Regulates Leukocyte Recruitment

Hafezi‐Moghadam, A., Thomas, K. L., Prorock, A. J., Huo, Y., & Ley, K. F. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.863 · Cited by 224

Membranes as messengers in T cell adhesion signaling

Dustin, M. L., Bivona, T. G., & Philips, M. R. (2004) · Nature Immunology · doi:10.1038/ni1057 · Cited by 224

T-cell trafficking in asthma: lipid mediators grease the way

Luster, A. D., & Tager, A. M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1438 · Cited by 213

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

Wymann, M. P., & Marone, R. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.011 · Cited by 212

Targeting leukocyte integrins in human diseases

Yonekawa, K. E., & Harlan, J. M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804460 · Cited by 193

The parting of the endothelium: miracle, or simply a junctional affair?

Johnson‐Léger, C., Aurrand‐Lions, M., & Imhof, B. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.6.921 · Cited by 188

Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation

Mathew, A., MacLean, J. A., DeHaan, E. N., Tager, A. M., Green, F. H. Y., & Luster, A. D. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1087 · Cited by 179

Leukocyte Arrest During Cytokine-Dependent Inflammation In Vivo

Kunkel, E. J., Dunne, J. L., & Ley, K. F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3301 · Cited by 166

Travellers in many guises: The origins and destinations of dendritic cells

Cavanagh, L. L., & von Andrian, U. H. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01119.x · Cited by 153

Bimolecular Complex between Rolling and Firm Adhesion Receptors Required for Cell Arrest

Nandi, A., Estess, P., & Siegelman, M. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00077-9 · Cited by 150

Colonic epithelial cells are a major site of macrophage inflammatory protein 3α (MIP-3α) production in normal colon and inflammatory bowel disease

Kwon, J. H., Keates, S. E., Bassani, L., Mayer, L. F., & Keates, A. C. (2002) · Gut · doi:10.1136/gut.51.6.818 · Cited by 150

Acquisition of Selectin Binding and Peripheral Homing Properties by CD4+ and CD8+ T Cells

Xie, H., Lim, Y.-C., Luscinskas, F. W., & Lichtman, A. H. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1765 · Cited by 138

CXCR2- and E-Selectin–induced Neutrophil Arrest during Inflammation In Vivo

Smith, M. L., Olson, T. S., & Ley, K. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040424 · Cited by 138

Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix

Vaday, G. G., Franitza, S., Schor, H., Hecht, I., Brill, A. G., Cahalon, L., Hershkoviz, R., & Lider, O. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.885 · Cited by 138

Reversing systemic inflammatory response syndrome with chemokine receptor pepducins

Kaneider, N. C., Agarwal, A., Leger, A. J., & Kuliopulos, A. (2005) · Nature Medicine · doi:10.1038/nm1245 · Cited by 137

Regulation of endothelial cell contacts during leukocyte extravasation.

Vestweber, D. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00372-1 · Cited by 125

Absence of the Endothelial Oxidase AOC3 Leads to Abnormal Leukocyte Traffic In Vivo

Stolen, C., Marttila‐Ichihara, F., Koskinen, K., Yegutkin, G. G., Turja, R., Bono, P., Skurnik, M., Hänninen, A. L. M., Jalkanen, S., & Salmi, M. (2005) · Immunity · doi:10.1016/j.immuni.2004.12.006 · Cited by 125

LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds

Kinashi, T., Aker, M., Sokolovsky-Eisenberg, M., Grabovsky, V., Tanaka, C., Shamri, R., Feigelson, S. W., Etzioni, A., & Alon, R. (2003) · Blood · doi:10.1182/blood-2003-07-2499 · Cited by 112

Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium

Baltus, T., Weber, K. S. C., Johnson, Z., Proudfoot, A. E. I., & Weber, C. (2003) · Blood · doi:10.1182/blood-2003-04-1175 · Cited by 108

Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin α X β 2

Vorup‐Jensen, T., Carman, C. V., Shimaoka, M., Schuck, P., Švitel, J., & Springer, T. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409057102 · Cited by 98

Targeting Monocyte Recruitment in CNS Autoimmune Disease

Izikson, L., Klein, R. S., Luster, A. D., & Weiner, H. L. (2002) · Clinical Immunology · doi:10.1006/clim.2001.5167 · Cited by 89

Rolling of Th1 Cells via P-Selectin Glycoprotein Ligand-1 Stimulates LFA-1-Mediated Cell Binding to ICAM-1

Atarashi, K., Hirata, T., Matsumoto, M., Kanemitsu, N., & Miyasaka, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1424 · Cited by 87

Role of chemokines in the development of secondary and tertiary lymphoid tissues

Cupedo, T., & Mebius, R. E. (2003) · Seminars in Immunology · doi:10.1016/j.smim.2003.08.002 · Cited by 63

Blockade of α6 integrin inhibits IL-1β- but not TNF-α-induced neutrophil transmigration in vivo

Dangerfield, J. P., Wang, S., & Nourshargh, S. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704421 · Cited by 54

Cutting Edge: Th2 Cell Trafficking into the Allergic Lung Is Dependent on Chemoattractant Receptor Signaling

Mathew, A., Medoff, B. D., Carafone, A. D., & Luster, A. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.651 · Cited by 46

Therapeutic Antagonists and the Conformational Regulation of the β2 Integrins

Shimaoka, M., & Springer, T. A. (2004) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026043387575 · Cited by 44

Arrest Chemokines

Ley, K. F. (2003) · Microcirculation · doi:10.1038/sj.mn.7800194 · Cited by 44

Glycosaminoglycans and the Regulation of Allergic Inflammation

Rose, M., & Page, C. P. (2004) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010043343589 · Cited by 29

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932

Identification of splenic reservoir monocytes and their deployment to inflammatory sites

Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221

A cytokine-mediated link between innate immunity, inflammation, and cancer

Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806

Regulation of inflammation by short chain fatty acids

Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724

Targeting cells in motion: Migrating toward improved therapies

Griffith, J. W., & Luster, A. D. (2013) · European Journal of Immunology · doi:10.1002/eji.201243183 · Cited by 34

Targeting immune cell migration as therapy for inflammatory disease: a review

Song, B., Guo, W., He, Y., Yao, X., Sun, J., & Wang, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1650760 · Cited by 14

Editorial: Recruitment of leukocytes during resolution of inflammation

de Oliveira, V. L. S., & Struyf, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1808267

Chemokine-Chemokine Receptor Network in Immune Cell Trafficking

Kim, C. H. (2004) · Current Drug Targets - Immune Endocrine & Metabolic Disorders · doi:10.2174/1568008043339712 · Cited by 95

Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics

Luscinskas, F. W., & Imhof, B. A. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0422-z