The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides
Open accessAbstract
It remains difficult to distinguish tumor recurrence from radiation necrosis after brain tumor therapy. Here we show that these lesions can be distinguished using the amide proton transfer (APT) magnetic resonance imaging (MRI) signals of endogenous cellular proteins and peptides as an imaging biomarker. When comparing two models of orthotopic glioma (SF188/V+ glioma and 9L gliosarcoma) with a model of radiation necrosis in rats, we could clearly differentiate viable glioma (hyperintense) from radiation necrosis (hypointense to isointense) by APT MRI. When we irradiated rats with U87MG gliomas, the APT signals in the irradiated tumors had decreased substantially by 3 d and 6 d after radiation. The amide protons that can be detected by APT provide a unique and noninvasive MRI biomarker for distinguishing viable malignancy from radiation necrosis and predicting tumor response to therapy.
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Cites
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Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations
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Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI
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Self-citationClinical features, mechanisms, and management of pseudoprogression in malignant gliomas
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Amide proton transfer (APT) contrast for imaging of brain tumors
Zhou, J., Lal, B., Wilson, D. A., Laterra, J., & van Zijl, P. C. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10651 · Cited by 660
Self-citationGriffiths, Jr. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.326 · Cited by 594
Howe, F. A., Barton, S. J., Cudlip, S. A., Stubbs, M., Saunders, D. E., Murphy, M., Wilkins, P., Opstad, K. S., Doyle, V. L., McLean, M. A., et al. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10367 · Cited by 539
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Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
van Zijl, P. C. M., & Yadav, N. N. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22761 · Cited by 1,155
Self-citationvan Zijl, P. C. M., Lam, W. W., Xu, J., Knutsson, L., & Stanisz, G. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.04.045 · Cited by 339
Self-citationZaiss, M., & Bachert, P. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/22/r221 · Cited by 323
Pseudoprogression of brain tumors
Thust, S. C., van den Bent, M. J., & Smits, M. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26171 · Cited by 304
Clinical applications of chemical exchange saturation transfer (CEST) MRI
Jones, K. M., Pollard, A. C., & Pagel, M. D. (2018) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25838 · Cited by 287
Jin, T., Wang, P., Zong, X., & Kim, S. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24315 · Cited by 273
Xiao, P., Huang, J., Han, X., Cheu, J. W. S., Liu, Y., Law, L. H., Lai, J. H. C., Li, J., Park, S. W., Wong, C. C. L., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c10493 · Cited by 14
Magnetic resonance imaging techniques for monitoring glioma response to chemoradiotherapy
Lawrence, L. S. P., Maralani, P. J., Das, S., Sahgal, A., Stanisz, G. J., & Lau, A. Z. (2025) · Journal of Neuro-Oncology · doi:10.1007/s11060-024-04856-3 · Cited by 4
Metadata
- Authors
- Zhou, J., Tryggestad, E., Wen, Z., Lal, B., Zhou, T., Grossman, R., Wang, S., Yan, K., Fu, D.-X., Ford, E., Tyler, B., Blakeley, J., Laterra, J., & van Zijl, P. C. M.
- Venue
- Nature Medicine
- Published
- 2010-12-19
- Volume
- 17
- Issue
- 1
- Pages
- 130-134
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2048919807
- Cited by
- 526
- References
- 27
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- green
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