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Cited by 526

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

Open access
Zhou, Jinyuan, Tryggestad, Erik, Wen, Zhibo, Lal, Bachchu, Zhou, Tingting, Grossman, Rachel, Wang, Silun, Yan, Kun, Fu, De-Xue, Ford, Eric, Tyler, Betty, Blakeley, Jaishri, Laterra, John, van Zijl, Peter C M·2011·Nature Medicine
DOI 10.1038/nm.2268
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Abstract

It remains difficult to distinguish tumor recurrence from radiation necrosis after brain tumor therapy. Here we show that these lesions can be distinguished using the amide proton transfer (APT) magnetic resonance imaging (MRI) signals of endogenous cellular proteins and peptides as an imaging biomarker. When comparing two models of orthotopic glioma (SF188/V+ glioma and 9L gliosarcoma) with a model of radiation necrosis in rats, we could clearly differentiate viable glioma (hyperintense) from radiation necrosis (hypointense to isointense) by APT MRI. When we irradiated rats with U87MG gliomas, the APT signals in the irradiated tumors had decreased substantially by 3 d and 6 d after radiation. The amide protons that can be detected by APT provide a unique and noninvasive MRI biomarker for distinguishing viable malignancy from radiation necrosis and predicting tumor response to therapy.

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Crossref · 10.1038/nm.2268

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Metadata

Authors
Zhou, J., Tryggestad, E., Wen, Z., Lal, B., Zhou, T., Grossman, R., Wang, S., Yan, K., Fu, D.-X., Ford, E., Tyler, B., Blakeley, J., Laterra, J., & van Zijl, P. C. M.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2010-12-19
Volume
17
Issue
1
Pages
130-134
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.2268
OpenAlex
W2048919807
Cited by
526
References
27
FWCI
17.60
Type
journal article
Language
en
Open access
green

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