The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue
Open accessAbstract
Promoting brown adipose tissue (BAT) formation and function may reduce obesity. Recent data link retinoids to energy balance, but a specific role for retinoid metabolism in white versus brown fat is unknown. Retinaldehyde dehydrogenases (Aldhs), also known as aldehyde dehydrogenases, are rate-limiting enzymes that convert retinaldehyde (Rald) to retinoic acid. Here we show that Aldh1a1 is expressed predominately in white adipose tissue (WAT), including visceral depots in mice and humans. Deficiency of the Aldh1a1 gene induced a BAT-like transcriptional program in WAT that drove uncoupled respiration and adaptive thermogenesis. WAT-selective Aldh1a1 knockdown conferred this BAT program in obese mice, limiting weight gain and improving glucose homeostasis. Rald induced uncoupling protein-1 (Ucp1) mRNA and protein levels in white adipocytes by selectively activating the retinoic acid receptor (RAR), recruiting the coactivator PGC-1α and inducing Ucp1 promoter activity. These data establish Aldh1a1 and its substrate Rald as previously unrecognized determinants of adipocyte plasticity and adaptive thermogenesis, which may have potential therapeutic implications.
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Cites
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Adaptive thermogenesis in adipocytes: Is beige the new brown?
Wu, J., Cohen, P., & Spiegelman, B. M. (2013) · Genes & Development · doi:10.1101/gad.211649.112 · Cited by 828
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Metadata
- Authors
- Kiefer, F. W., Vernochet, C., O'Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., & Plutzky, J.
- Venue
- Nature Medicine
- Published
- 2012-05-06
- Volume
- 18
- Issue
- 6
- Pages
- 918-925
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1997032129
- Cited by
- 213
- References
- 11
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Kiefer, F. W., Vernochet, C., O'Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., & Plutzky, J. (2012). Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nature Medicine. https://doi.org/10.1038/nm.2757
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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