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Cited by 667

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Open access
Cypess, Aaron M, White, Andrew P, Vernochet, Cecile, Schulz, Tim J, Xue, Ruidan, Sass, Christina A, Huang, Tian Liang, Roberts-Toler, Carla, Weiner, Lauren S, Sze, Cathy, Chacko, Aron T, Deschamps, Laura N, Herder, Lindsay M, Truchan, Nathan, Glasgow, Allison L, Holman, Ashley R, Gavrila, Alina, Hasselgren, Per-Olof, Mori, Marcelo A, Molla, Michael, Tseng, Yu-Hua·2013·Nature Medicine
DOI 10.1038/nm.3112
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Abstract

The imbalance between energy intake and expenditure is the underlying cause of the current obesity and diabetes pandemics. Central to these pathologies is the fat depot: white adipose tissue (WAT) stores excess calories, and brown adipose tissue (BAT) consumes fuel for thermogenesis using tissue-specific uncoupling protein 1 (UCP1). BAT was once thought to have a functional role in rodents and human infants only, but it has been recently shown that in response to mild cold exposure, adult human BAT consumes more glucose per gram than any other tissue. In addition to this nonshivering thermogenesis, human BAT may also combat weight gain by becoming more active in the setting of increased whole-body energy intake. This phenomenon of BAT-mediated diet-induced thermogenesis has been observed in rodents and suggests that activation of human BAT could be used as a safe treatment for obesity and metabolic dysregulation. In this study, we isolated anatomically defined neck fat from adult human volunteers and compared its gene expression, differentiation capacity and basal oxygen consumption to different mouse adipose depots. Although the properties of human neck fat vary substantially between individuals, some human samples share many similarities with classical, also called constitutive, rodent BAT.

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Metadata

Authors
Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts-Toler, C., Weiner, L. S., Sze, C., Chacko, A. T., Deschamps, L. N., Herder, L. M., Truchan, N., Glasgow, A. L., Holman, A. R., Gavrila, A., Hasselgren, P.-O., Mori, M. A., Molla, M., & Tseng, Y.-H.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2013-04-21
Volume
19
Issue
5
Pages
635-639
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3112
OpenAlex
W2112076976
Cited by
667
References
10
FWCI
52.64
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. https://app.cochat.ai/papers/10.1038/nm.3112
The paper
Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts-Toler, C., Weiner, L. S., Sze, C., Chacko, A. T., Deschamps, L. N., Herder, L. M., Truchan, N., Glasgow, A. L., Holman, A. R., Gavrila, A., Hasselgren, P.-O., Mori, M. A., . . . Tseng, Y.-H. (2013). Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nature Medicine. https://doi.org/10.1038/nm.3112

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.