Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

Zimmermann, R., Strauss, J. G., Haemmerle, G., Schoiswohl, G., Birner-Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,116

Leptin-regulated endocannabinoids are involved in maintaining food intake

Di Marzo, V., Goparaju, S. K., Wang, L., Liu, J., Bátkai, S., Járai, Z., Fezza, F., Miura, G. I., Palmiter, R. D., Sugiura, T., et al. (2001) · Nature · doi:10.1038/35071088 · Cited by 1,559

Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia

Després, J.-P., Golay, A., & Sjöström, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044537 · Cited by 1,392

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278

Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients: RIO-North America: A Randomized Controlled Trial

Pi-Sunyer, F. X., Aronne, L. J., Heshmati, H. M., Devin, J., Rosenstock, J., & RIO-North America Study Group, F. T. (2006) · JAMA · doi:10.1001/jama.295.7.761 · Cited by 1,218

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Cota, D., Marsicano, G., Tschöp, M., Grübler, Y., Flachskamm, C., Schubert, M., Auer, D., Yassouridis, A., Thöne-Reineke, C., Ortmann, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17725 · Cited by 1,168

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

Osei-Hyiaman, D., DePetrillo, M., Pacher, P., Liu, J., Radaeva, S., Bátkai, S., Harvey-White, J., Mackie, K., Offertáler, L., Wang, L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523057 · Cited by 1,101

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010

Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

Cohen, P., Miyazaki, M., Socci, N. D., Hagge-Greenberg, A., Liedtke, W., Soukas, A. A., Sharma, R., Hudgins, L. C., Ntambi, J. M., & Friedman, J. M. (2002) · Science · doi:10.1126/science.1071527 · Cited by 821

Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism

Schweiger, M., Schreiber, R., Haemmerle, G., Lass, A., Fledelius, C., Jacobsen, P., Tornqvist, H., Zechner, R., & Zimmermann, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608048200 · Cited by 728

Mechanisms of nutritional and hormonal regulation of lipogenesis

Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700

Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

Matias, I., Gonthier, M.-P., Orlando, P., Martiadis, V., De Petrocellis, L., Cervino, C., Petrosino, S., Hoareau, L., Festy, F., Pasquali, R., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2679 · Cited by 656

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

Shimabukuro, M., Koyama, K., Chen, G., Wang, M.-Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4637 · Cited by 646

The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Komeda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103241200 · Cited by 637

Key enzyme in leptin-induced anorexia

Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585

Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

Blüher, M., Engeli, S., Klöting, N., Berndt, J., Fasshauer, M., Bátkai, S., Pacher, P., Schön, M. R., Jordan, J., & Stumvoll, M. (2006) · Diabetes · doi:10.2337/db06-0812 · Cited by 530

Leptin-specific patterns of gene expression in white adipose tissue

Soukas, A., Cohen, P., Socci, N. D., & Friedman, J. M. (2000) · Genes & Development · doi:10.1101/gad.14.8.963 · Cited by 516

Glyceroneogenesis and the triglyceride/fatty acid cycle

Reshef, L., Olswang, Y., Cassuto, H., Blum, B., Croniger, C. M., Kalhan, S. C., Tilghman, S. M., & Hanson, R. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300017200 · Cited by 475

Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro

Anthonsen, M. W., Rönnstrand, L., Wernstedt, C., Degerman, E., & Holm, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.215 · Cited by 468

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

de Luca, C., Kowalski, T. J., Zhang, Y., Elmquist, J. K., Lee, C., Kilimann, M. W., Ludwig, T., Liu, S.-M., & Chua, S. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24059 · Cited by 383

Novel Form of Lipolysis Induced by Leptin

Wang, M.-Y., Lee, Y., & Unger, R. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17541 · Cited by 364

Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway

Greenberg, A. S., Shen, W.-J., Muliro, K., Patel, S., Souza, S. C., Roth, R. A., & Kraemer, F. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104436200 · Cited by 363

Leptin selectively decreases visceral adiposity and enhances insulin action

Barzilai, N., Wang, J., Massilon, D., Vuguin, P., Hawkins, M., & Rossetti, L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119865 · Cited by 335

Anandamide induced PPARγ transcriptional activation and 3T3-L1 preadipocyte differentiation

Bouaboula, M., Hilairet, S., Marchand, J., Fajas, L., Fur, G. L., & Casellas, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.032 · Cited by 298

The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*

Fan, W., Dinulescu, D. M., Butler, A. A., Zhou, J., Marks, D. L., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7665 · Cited by 294

Integration of Endocannabinoid and Leptin Signaling in an Appetite-Related Neural Circuit

Jo, Y.-H., Chen, Y.-J. J., Chua, S. C., Talmage, D. A., & Role, L. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.021 · Cited by 234

Critical role of STAT3 in leptin's metabolic actions

Buettner, C., Pocai, A., Muse, E. D., Etgen, A. M., Myers, M. G., & Rossetti, L. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.014 · Cited by 228

The Endogenous Cannabinoid System Stimulates Glucose Uptake in Human Fat Cells via Phosphatidylinositol 3-Kinase and Calcium-Dependent Mechanisms

Pagano, C., Pilon, C., Calcagno, A., Urbanet, R., Rossato, M., Milan, G., Bianchi, K., Rizzuto, R., Bernante, P., Federspil, G., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0768 · Cited by 210

Interleukin-6 Regulation of AMP-Activated Protein Kinase

Ruderman, N. B., Keller, C., Richard, A.-M., Saha, A. K., Luo, Z., Xiang, X., Giralt, M., Ritov, V. B., Menshikova, E. V., Kelley, D. E., et al. (2006) · Diabetes · doi:10.2337/db06-s007 · Cited by 187

Phosphorylation of Recombinant Human ATP:Citrate Lyase by cAMP-Dependent Protein Kinase Abolishes Homotropic Allosteric Regulation of the Enzyme by Citrate and Increases the Enzyme Activity. Allosteric Activation of ATP:Citrate Lyase by Phosphorylated Sugars

Potapova, I. A., El-Maghrabi, M. R., Doronin, S. V., & Benjamin, W. B. (2000) · Biochemistry · doi:10.1021/bi992159y · Cited by 177

White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation

Giordano, A., Song, C. K., Bowers, R. R., Ehlen, J. C., Frontini, A., Cinti, S., & Bartness, T. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00679.2005 · Cited by 177

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

Bates, S. H., Kulkarni, R. N., Seifert, M., & Myers, M. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.001 · Cited by 173

Leptin: an essential regulator of lipid metabolism

Reidy, S. P., & Weber, J.-M. (2000) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(00)00159-8 · Cited by 158

Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity

Wang, M.-Y., Orci, L., Ravazzola, M., & Unger, R. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509001102 · Cited by 155

Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities

Guo, K., McMinn, J. E., Ludwig, T. E., Yu, Y., Yang, G., Chen, L., Loh, D., Cai, L., Chua, S. C., & Zhang, Y. (2007) · Endocrinology · doi:10.1210/en.2007-0261 · Cited by 134

White adipose tissue sympathetic nervous system denervation increases fat pad mass and fat cell number

Youngstrom, T. G., & Bartness, T. J. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1488 · Cited by 133

Local sympathetic denervation of white adipose tissue in rats induces preadipocyte proliferation without noticeable changes in metabolism

Cousin, B., Casteilla, L., Lafontan, M., Ambid, L., Langin, D., Berthault, M., & Pénicaud, L. (1993) · Endocrinology · doi:10.1210/endo.133.5.8404678 · Cited by 130

Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle

Saha, A. K., Vavvas, D. G., Kurowski, T. G., Apazidis, A., Witters, L. A., Shafrir, E., & Ruderman, N. B. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.4.e641 · Cited by 124

Regulation of adipogenesis and energy balance by PPARγ and PGC-1

Spiegelman, B. M., Puigserver, P., & Wu, Z. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801492 · Cited by 114

Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1

Tabor, D. E., Kim, J. B., Spiegelman, B. M., & Edwards, P. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.22052 · Cited by 108

Hypothalamic Phosphatidylinositol 3-Kinase Pathway of Leptin Signaling Is Impaired during the Development of Diet-Induced Obesity in FVB/N Mice

Metlakunta, A. S., Sahu, M., & Sahu, A. (2007) · Endocrinology · doi:10.1210/en.2007-1307 · Cited by 90

Identification of Endocannabinoids and Related Compounds in Human Fat Cells

Gonthier, M., Hoareau, L., Festy, F., Matias, I., Valenti, M., Bès-Houtmann, S., Rouch, C., Silva, C. R. D., Chesne, S., d’Hellencourt, C. L., et al. (2007) · Obesity · doi:10.1038/oby.2007.581 · Cited by 88

Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms

Muzumdar, R. H., Ma, X., Yang, X., Atzmon, G., Bernstein, J., Karkanias, G. B., & Barzilai, N. (2003) · The FASEB Journal · doi:10.1096/fj.02-0991fje · Cited by 69

Sympathetic denervation does not prevent a reduction in fat pad size of rats or mice treated with peripherally administered leptin

Rooks, C. R., Penn, D. M., Kelso, E., Bowers, R. R., Bartness, T. J., & Harris, R. B. S. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00858.2004 · Cited by 61

Lipoprotein lipase mRNA in white adipose tissue but not in skeletal muscle is increased by pioglitazone through PPAR-γ

Kageyama, H., Hirano, T., Okada, K., Ebara, T., Kageyama, A., Murakami, T., Shioda, S., & Adachi, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00663-6 · Cited by 56

Evidence for parasympathetic innervation of white adipose tissue, clearing up some vagaries

Kreier, F., & Buijs, R. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00890.2006 · Cited by 51

Hyperleptinemia Depletes Fat from Denervated Fat Tissue

Wang, Z.-W., Zhou, Y., Lee, Y., Higa, M., Kalra, S. P., & Unger, R. H. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0918 · Cited by 50

Cross-talk among gp130 Cytokines in Adipocytes

Zvonic, S., Baugh, J. E., Arbour-Reily, P., Mynatt, R. L., & Stephens, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508020200 · Cited by 43

The Endocannabinoid System: Mechanisms Behind Metabolic Homeostasis and Imbalance

Woods, S. C. (2007) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.11.013 · Cited by 33

Adapting to obesity with adipose tissue inflammation

Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026

Adipocytokines and the Metabolic Complications of Obesity

Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 743

The endocannabinoid system links gut microbiota to adipogenesis

Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

Silvestri, C., & Di Marzo, V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.001 · Cited by 543