Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Innate immune recognition

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Immunobiology of Dendritic Cells

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A Toll-like receptor recognizes bacterial DNA

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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

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Toll-like receptors: critical proteins linking innate and acquired immunity

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Tolerogenic Dendritic Cells

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An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling

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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

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Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

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Natural adjuvants: Endogenous activators of dendritic cells

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Novel Signal Transduction Pathway Utilized by Extracellular HSP70

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Consequences of Cell Death

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Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway

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Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

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HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

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CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

Basu, S., Binder, R. J., Ramalingam, T., & Srivastava, P. K. (2001) · Immunity · doi:10.1016/s1074-7613(01)00111-x · Cited by 900

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

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Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses

Srivastava, P. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064801 · Cited by 850

CD91: a receptor for heat shock protein gp96

Binder, R. J., Han, D. K., & Srivastava, P. K. (2000) · Nature Immunology · doi:10.1038/77835 · Cited by 671

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

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Heat Shock Protein–Peptide Complexes, Reconstituted In Vitro, Elicit Peptide-specific Cytotoxic T Lymphocyte Response and Tumor Immunity

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Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

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Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells

Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K., & Akira, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5688 · Cited by 489

CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

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Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

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Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

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Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

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Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages

Gao, B., & Tsan, M.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208742200 · Cited by 396

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

Singh-Jasuja, H., Scherer, H. U., Hilf, N., Arnold-Schild, D., Rammensee, H.-G., Toes, R. E. M., & Schild, H. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(2000)30:18<2211::aid-immu2211>3.0.co;2-h · Cited by 380

CD40, an extracellular receptor for binding and uptake of Hsp70–peptide complexes

Becker, T., Hartl, F.-U., & Wieland, F. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200208083 · Cited by 355

CD40 Is a Cellular Receptor Mediating Mycobacterial Heat Shock Protein 70 Stimulation of CC-Chemokines

Wang, Y., Kelly, C. G., Karttunen, J. T., Whittall, T., Lehner, P. J., Duncan, L., MacAry, P., Younson, J. S., Singh, M., Oehlmann, W., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00242-4 · Cited by 270

Primary Tumor Tissue Lysates Are Enriched in Heat Shock Proteins and Induce the Maturation of Human Dendritic Cells

Somersan, S., Larsson, M., Fonteneau, J. F., Basu, S., Srivastava, P., & Bhardwaj, N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4844 · Cited by 258

T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides

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Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway

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Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

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Cutting Edge: Heat Shock Protein gp96 Induces Maturation and Migration of CD11c+ Cells In Vivo

Binder, R. J., Anderson, K. M., Basu, S., & Srivastava, P. K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6029 · Cited by 216

The role of heat shock protein (hsp70) in dendritic cell maturation: Hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

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Immature Dendritic Cells Acquire Cd8+Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli

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Immunization with a Lymphocytic Choriomeningitis Virus Peptide Mixed with Heat Shock Protein 70 Results in Protective Antiviral Immunity and Specific Cytotoxic T Lymphocytes

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Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70

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Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

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Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

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HSP70 peptide-bearing and peptide-negative preparations act as chaperokines

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Role of Antigen-Presenting Cells in Mediating Tolerance and Autoimmunity

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TERMINATION OF TOLERANCE TO HUMAN GAMMA GLOBULIN IN MICE BY ANTIGEN AND BACTERIAL LIPOPOLYSACCHARIDE (ENDOTOXIN)

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A Proposed Mechanism for the Induction of Cytotoxic T Lymphocyte Production by Heat Shock Fusion Proteins

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Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

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Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process

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Purification of Heat Shock Protein–Peptide Complexes for Use in Vaccination against Cancers and Intracellular Pathogens

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In Vivo and In Vitro Activation of T Cells After Administration of Ag-Negative Heat Shock Proteins

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Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice

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Calcineurin Aα plays an exclusive role in TCR signaling in mature but not in immature T cells

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CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses

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Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

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Getting under the skin: the immunogenetics of psoriasis

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The testis in immune privilege

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A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice

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