Environmental standardization: cure or cause of poor reproducibility in animal experiments?

The Principles of Humane Experimental Technique

(1960) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1960.tb73127.x · Cited by 4,912

Handbook of ethological methods

(1997) · Choice Reviews Online · doi:10.5860/choice.34-4483 · Cited by 1,720

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666

Factors relevant to the validity of experiments in social settings.

Campbell, D. T. (1957) · Psychological Bulletin · doi:10.1037/h0040950 · Cited by 1,140

Mouse genetics: concepts and applications

(1995) · Choice Reviews Online · doi:10.5860/choice.33-2135 · Cited by 758

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Rampon, C., Tang, Y.-P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z. (2000) · Nature Neuroscience · doi:10.1038/72945 · Cited by 755

Reproducibility of SELDI-TOF protein patterns in serum: comparing datasets from different experiments

Baggerly, K. A., Morris, J. S., & Coombes, K. R. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg484 · Cited by 621

Phenotypic plasticity : functional and conceptual approaches

DeWitt, T. J., & Scheiner, S. M. (2004) · Cited by 578

Phenotypic Plasticity: Functional and Conceptual Approaches

(2004) · doi:10.1093/oso/9780195138962.001.0001 · Cited by 542

Research in the Psychological Laboratory: Truth or Triviality?

Anderson, C. A., Lindsay, J. J., & Bushman, B. J. (1999) · Current Directions in Psychological Science · doi:10.1111/1467-8721.00002 · Cited by 505

Different data from different labs: Lessons from studies of gene–environment interaction

Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart‐Kasch, S., Dorow, J., Doerksen, S., Downing, C., Fogarty, J., Rodd‐Henricks, K., et al. (2003) · Journal of Neurobiology · doi:10.1002/neu.10173 · Cited by 495

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H.-P., Nakanishi, S., Wehner, J. M., Giese, K. P., Tully, T., Abel, T., Chapman, P. F., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80958-7 · Cited by 479

From house mouse to mouse house: the behavioural biology of free-living Mus musculus and its implications in the laboratory

Latham, N., & Mason, G. (2004) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2004.02.006 · Cited by 339

Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive

Chesler, E. J., Wilson, S. G., Lariviere, W. R., Rodriguez-Zas, S. L., & Mogil, J. S. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00103-3 · Cited by 331

Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

Mandillo, S., Tucci, V., Hölter, S. M., Meziane, H., Banchaabouchi, M. A., Kallnik, M., Lad, H. V., Nolan, P. M., Ouagazzal, A.-M., Coghill, E. L., et al. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90207.2008 · Cited by 282

Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades

Wahlsten, D., Bachmanov, A., Finn, D. A., & Crabbe, J. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605342103 · Cited by 281

Principles of Laboratory Animal Science

van Zutphen, L. F. M., Baumans, V., Beynen, A. C., & Restani, P. (1996) · Cited by 253

Animal models of behavioral dysfunctions: Basic concepts and classifications, and an evaluation strategy

van der Staay, F. J. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.01.006 · Cited by 252

Cage enrichment and mouse behaviour

Wolfer, D. P., Litvin, O., Morf, S., Nitsch, R. M., Lipp, H.-P., & Würbel, H. (2004) · Nature · doi:10.1038/432821a · Cited by 245

Influence of gender and age on performance of rats in the elevated plus maze apparatus

IMHOF, J. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90036-p · Cited by 236

Behaviour and the standardization fallacy

Würbel, H. (2000) · Nature Genetics · doi:10.1038/81541 · Cited by 234

Abolition and Reversal of Strain Differences in Behavioral Responses to Drugs of Abuse After a Brief Experience

Cabib, S., Orsini, C., Moal, M. L., & Piazza, P. V. (2000) · Science · doi:10.1126/science.289.5478.463 · Cited by 233

Genetic and Environmental Effects on Complex Traits in Mice

Valdar, W., Solberg, L. C., Gauguier, D., Cookson, W. O., Rawlins, J. N. P., Mott, R., & Flint, J. (2006) · Genetics · doi:10.1534/genetics.106.060004 · Cited by 207

Rearing environmental enrichment in two inbred strains of mice: 1. Effects on emotional reactivity

Chapillon, P., Manneché, C., Belzung, C., & Caston, J. (1999) · Behavior Genetics · doi:10.1023/a:1021437905913 · Cited by 202

Behavioral phenotyping enhanced – beyond (environmental) standardization

Würbel, H. (2002) · Genes, Brain and Behavior · doi:10.1046/j.1601-1848.2001.00006.x · Cited by 182

Standardizing tests of mouse behavior: Reasons, recommendations, and reality

Wahlsten, D. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00527-3 · Cited by 165

Environmental bias? Effects of housing conditions, laboratory environment and experimenter on behavioral tests

Lewejohann, L., Reinhard, C., Schrewe, A., Brandewiede, J., Haemisch, A., Goertz, N., Schachner, M., & Sachser, N. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00140.x · Cited by 158

Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety

Andrews, N., & File, S. E. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90827-5 · Cited by 152

Behavioural and glial changes in old rats following environmental enrichment

Soffié, M., Hahn, K., Terao, E., & Eclancher, F. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00139-9 · Cited by 139

Strain specific behavioural response to environmental enrichment in the mouse.

de Weerd, H. A. V., Baumans, V., Koolhaas, J. M., & van Zutphen, L. F. M. (1994) · PubMed · Cited by 134

Experimental Localism and External Validity

Guala, F. (2003) · Philosophy of Science · doi:10.1086/377400 · Cited by 126

Genotype–environment interactions in mouse behavior: A way out of the problem

Kafkafi, N., Benjamini, Y., Sakov, A., Elmer, G. I., & Golani, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409554102 · Cited by 100

The fallacy of behavioral phenotyping without standardisation

van der Staay, F. J., & Steckler, T. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00007.x · Cited by 98

Common variations in the pretest environment influence genotypic comparisons in models of anxiety

Izídio, G. S., Lopes, D. M., Spricigo, L., & Ramos, A. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00121.x · Cited by 92

Behavioural phenotyping of mouse mutants

van der Staay, F. J., & Steckler, T. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00278-9 · Cited by 78

Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment

Boehm, G. W., Sherman, G. F., Hoplight, B. J., Hyde, L. A., Waters, N. S., Bradway, D. M., Galaburda, A. M., & Denenberg, V. H. (1996) · Brain Research · doi:10.1016/0006-8993(96)00299-5 · Cited by 68

Dissecting complex behaviours in the post-genomic era

Kas, M. J., & van Ree, J. M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.011 · Cited by 64

Resolving differences in GABAA receptor mutant mouse studies

Crestani, F., Martin, J. R., Möhler, H., & Rudolph, U. (2000) · Nature Neuroscience · doi:10.1038/80553 · Cited by 59

The Design of Animal Experiments

Festing, M. F. W. (2010) · Wiley eBooks · doi:10.1002/9781444318777.ch3 · Cited by 48

Influence of Age on Behavioural Response in the Light/Dark Paradigm

Hascoët, M., Colombel, M.-C., & Bourin, M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00333-3 · Cited by 44

Animal definition: a necessity for the validity of animal experiments?

Örink, K. J., & Rehbinder, C. (2000) · Laboratory Animals · doi:10.1258/002367700780457608 · Cited by 41

Effect of Cage Size on Ultradian Locomotor Rhythms of Laboratory Mice

Poon, A. M. S., Wu, B. M., Poon, P. W. F., Cheung, E. P. W., Chan, F. H. Y., & Lam, F. K. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00305-3 · Cited by 40

Exploiting human anatomical variability as a link between genome and cognome

Leonard, C. M., Eckert, M. A., & Kuldau, J. M. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00196.x · Cited by 38

Refinement and Reduction through the Control of Variation

Festing, M. F. W. (2004) · Alternatives to Laboratory Animals · doi:10.1177/026119290403201s43 · Cited by 27

Good Experimental Design and Statistics Can save Animals, But how can it be Promoted?

Festing, M. F. W. (2004) · Alternatives to Laboratory Animals · doi:10.1177/026119290403201s20 · Cited by 13

Knockout Mice: Is It Just Genetics? Effect of Enriched Housing on Fibulin-4+/− Mice

Cudilo, E. M., Al‐Naemi, H. A., Marmorstein, L. Y., & Baldwin, A. L. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000229 · Cited by 8

Updating Animal Welfare Thinking: Moving beyond the “Five Freedoms” towards “A Life Worth Living”

Mellor, D. (2016) · Animals · doi:10.3390/ani6030021 · Cited by 948

Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease

Morris, G. P., Clark, I. A., & Vissel, B. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0135-5 · Cited by 522

Environmental enrichment, new neurons and the neurobiology of individuality

Kempermann, G. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0120-x · Cited by 477

Reproducibility of preclinical animal research improves with heterogeneity of study samples

Voelkl, B., Vogt, L., Sena, E. S., & Würbel, H. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2003693 · Cited by 262

Reproducibility and replicability of rodent phenotyping in preclinical studies

Kafkafi, N., Agassi, J., Chesler, E. J., Crabbe, J. C., Crusio, W. E., Eilam, D., Gerlai, R., Golani, I., Gomez-Marin, A., Heller, R., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.003 · Cited by 215