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Cited by 184Neural and Behavioral Psychology StudiesNeural dynamics and brain functionMemory and Neural Mechanisms

Evaluating self-generated decisions in frontal pole cortex of monkeys

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Tsujimoto, Satoshi, Genovesio, Aldo, Wise, Steven P·2010·Nature Neuroscience
DOI 10.1038/nn.2453PMC PMC2834888
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Abstract

The frontal pole cortex (FPC) expanded markedly during human evolution, but its function remains uncertain in both monkeys and humans. Accordingly, we examined single-cell activity in this area. On every trial, monkeys decided between two response targets on the basis of a 'stay' or 'shift' cue. Feedback followed at a fixed delay. FPC cells did not encode the monkeys' decisions when they were made, but did so later on, as feedback approached. This finding indicates that the FPC is involved in monitoring or evaluating decisions. Using a control task and delayed feedback, we found that decision coding lasted until feedback only when the monkeys combined working memory with sensory cues to 'self-generate' decisions, as opposed to when they simply followed trial-by-trial instructions. A role in monitoring or evaluating self-generated decisions could account for FPC's expansion during human evolution.

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  • Postdecisional firing rates of neurons in prefrontal cortex and dopaminergic midbrain covary with choice correctness before explicit feedback is given.

    “In animal models, postdecisional firing rates of neurons in prefrontal cortex and dopaminergic midbrain have also been shown to covary with choice correctness before explicit feedback is given (Kepecs et al. 2008, Middlebrooks & Sommer 2012, Tsujimoto et al. 2010).”

    From Metacognition and Confidence: A Review and Synthesis (2024) · cites this paper as Tsujimoto et al. 2010

    The Results (Error trials; page unavailable) report that frontal pole cortex firing rates differed between correct and error trials during the pre-feedback period. The Discussion (Reward and trial outcome; page unavailable) likewise says this difference preceded feedback. The paper does not report recordings from dopaminergic midbrain neurons, so it supports only the prefrontal-cortex part of the sentence. (LLM, conf=0.87)

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Research works printed but not linked: 43

  1. [2]Ramnani N Owen AM Anterior prefrontal cortex: Insights into function from anatomy and neuroimaging Nat. Rev. Neurosci 2004 5 184 194 14976518
  2. [3]Burgess PW Simons JS Dumontheil I Gilbert SJ Duncan J McLeod P Phillips L The gateway hypothesis of rostral prefrontal cortex (area 10) function Measuring the mind: Speed, control, and age 2009 215 246 Oxford University Press Oxford
  3. [4]Öngür D Ferry AT Price JL Architectonic subdivision of the human orbital and medial prefrontal cortex J. Comp. Neurol 2003 460 425 449 12692859
  4. [5]Semendeferi K Armstrong E Schleicher A Zilles K Van Hoesen GW Prefrontal cortex in humans and apes: A comparative study of area 10 Am. J. Phys. Anthropol 2001 114 224 241 11241188
  5. [6]Jones EG Powell TPS An anatomical study of converging sensory pathways within the cerebral cortex of the monkey Brain 1970 93 793 820 4992433
  6. [7]Carmichael ST Price JL Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys J. Comp. Neurol 1996 371 179 207 8835726
  7. [8]Petrides M Pandya DN Efferent association pathways from the rostral prefrontal cortex in the macaque monkey J. Neurosci 2007 27 11573 11586 17959800 PMC6673207
  8. [10]Jacobs B Regional dendritic and spine variation in human cerebral cortex: A quantitative Golgi study Cereb. Cortex 2001 11 558 571 11375917
  9. [11]Sakai K Task set and prefrontal cortex Annu. Rev. Neurosci 2008 31 219 245 18558854
  10. [12]Okuda J Differential involvement of regions of rostral prefrontal cortex (Brodmann area 10) in time- and event-based prospective memory Int. J. Psychophysiol 2007 64 233 246 17126435
  11. [14]Koechlin E Basso G Pietrini P Panzer S Grafman J The role of the anterior prefrontal cortex in human cognition Nature 1999 399 148 151 10335843
  12. [15]Daw ND O’Doherty JP Dayan P Seymour B Dolan RJ Cortical substrates for exploratory decisions in humans Nature 2006 441 876 879 16778890 PMC2635947
  13. [16]Soon CS Brass M Heinze HJ Haynes JD Unconscious determinants of free decisions in the human brain Nat. Neurosci 2008 11 543 545 18408715
  14. [17]Ramnani N Elliott R Athwal BS Passingham RE Prediction error for free monetary reward in the human prefrontal cortex Neuroimage 2004 23 777 786 15528079
  15. [18]Boorman ED Behrens TEJ Woolrich MW Rushworth MFS How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action Neuron 2009 62 733 743 19524531
  16. [19]Burgess PW Dumontheil I Gilbert SJ The gateway hypothesis of rostral prefrontal cortex (area 10) function Trends Cogn. Sci 2007 11 290 298 17548231
  17. [20]Kroger JK Recruitment of anterior dorsolateral prefrontal cortex in human reasoning: A parametric study of relational complexity Cereb. Cortex 2002 12 477 485 11950765
  18. [21]Bunge SA Helskog EH Wendelken C Left, but not right, rostrolateral prefrontal cortex meets a stringent test of the relational integration hypothesis Neuroimage 2009 46 338 342 19457362 PMC2864011
  19. [22]Christoff K Ream JM Geddes LP Gabrieli JD Evaluating self-generated information: Anterior prefrontal contributions to human cognition Behav. Neurosci 2003 117 1161 1168 14674837
  20. [23]Zysset S Huber O Ferstl E von Cramon DY The anterior frontomedian cortex and evaluative judgment: An fMRI study Neuroimage 2002 15 983 991 11906238
  21. [24]Ganis G Kosslyn SM Stose S Thompson WL Yurgelun-Todd DA Neural correlates of different types of deception: An fMRI investigation Cereb. Cortex 2003 13 830 836 12853369
  22. [25]Karim AA The truth about lying: Inhibition of the anterior prefrontal cortex improves deceptive behavior Cereb. Cortex 2009 PMID: 19443622 19443622
  23. [26]Mitz AR Tsujimoto S Maclarty AJ Wise SP A method for recording single-cell activity in the frontal-pole cortex of macaque monkeys J. Neurosci. Methods 2009 177 60 66 18977387 PMC2743606
  24. [27]Genovesio A Brasted PJ Mitz AR Wise SP Prefrontal cortex activity related to abstract response strategies Neuron 2005 47 307 320 16039571 PMC1262638
  25. [28]Genovesio A Brasted PJ Wise SP Representation of future and previous spatial goals by separate neural populations in prefrontal cortex J. Neurosci 2006 26 7281 7292 16822988 PMC1501084
  26. [29]Tsujimoto S Genovesio A Wise SP Transient neuronal correlations underlying goal selection and maintenance in prefrontal cortex Cereb. Cortex 2008 18 2748 2761 18359779 PMC2583151
  27. [31]Pochon JB The neural system that bridges reward and cognition in humans: An fMRI study Proc. Natl. Acad. Sci. U.S.A 2002 99 5669 5674 11960021 PMC122829
  28. [32]Schall JD Stuphorn V Brown JW Monitoring and control of action by the frontal lobes Neuron 2002 36 309 322 12383784
  29. [34]Kepecs A Uchida N Zariwala HA Mainen ZF Neural correlates, computation and behavioural impact of decision confidence Nature 2008 455 227 231 18690210
  30. [35]Genovesio A Tsujimoto S Wise SP Encoding problem-solving strategies in prefrontal cortex: Activity during strategic errors Eur. J. Neurosci 2008 27 984 990 18279367 PMC2292125
  31. [37]Walsh ND Phillips ML Interacting outcome retrieval, anticipation, and feedback processes in the human brain Cereb. Cortex 2009 PMID: 19429861 PMC2803730 19429861
  32. [38]Lawrence NS Jollant F O’Daly O Zelaya F Phillips ML Distinct roles of prefrontal cortical subregions in the Iowa gambling task Cereb. Cortex 2009 19 1134 1143 18787233
  33. [39]Burgess PW Function and localization within rostral prefrontal cortex (area 10) Phil. Trans. Roy. Soc. Lond., Series B, Biol. Sci 2007 362 887 899 PMC2430004 17403644
  34. [40]Gilbert SJ Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis J. Cogn. Neurosci 2006 18 932 948 16839301
  35. [41]Mason MF Wandering minds: The default network and stimulus-independent thought Science 2007 315 393 395 17234951 PMC1821121
  36. [42]Gusnard DA Akbudak E Shulman GL Raichle ME Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function Proc. Natl. Acad. Sci. U.S.A 2001 98 4259 4264 11259662 PMC31213
  37. [43]Christoff K Ream JM Gabrieli JD Neural basis of spontaneous thought processes Cortex 2004 40 623 630 15505972
  38. [44]Forstmann BU Brass M Koch I von Cramon DY Internally generated and directly cued task sets: an investigation with fMRI Neuropsychologia 2005 43 943 952 15716164
  39. [45]Raichle ME A default mode of brain function Proc. Natl. Acad. Sci. U.S.A 2001 98 676 682 11209064 PMC14647
  40. [46]Bengtsson SL Haynes JD Sakai K Buckley MJ Passingham RE The representation of abstract task rules in the human prefrontal cortex Cereb. Cortex 2009 19 1929 1936 19047573 PMC2705703
  41. [47]Sakai K Passingham RE Prefrontal set activity predicts rule-specific neural processing during subsequent cognitive performance J. Neurosci 2006 26 1211 1218 16436608 PMC6674561
  42. [48]Bunge SA How we use rules to select actions: A review of evidence from cognitive neuroscience Cogn. Affect. Behav. Neurosci 2004 4 564 579 15849898
  43. [50]Mitz AR A liquid-delivery device that provides precise reward control for neurophysiological and behavioral experiments J. Neurosci. Methods 2005 148 19 25 16168492

Cited by

Sorted by citations

Authors
Tsujimoto, S., Genovesio, A., & Wise, S. P.
Affiliations
National Institutes of Health (US)
Corresponding author
Tsujimoto, Satoshi
ORCID
Genovesio, Aldo
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2009-12-06
Volume
13
Issue
1
Pages
120-126
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.2453
PMC
PMC2834888
OpenAlex
W2153129295
Cited by
184
References
5
Citations by year
2026: 7 · 2025: 12 · 2024: 12 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 13 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 14 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 16
FWCI
7.12
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (Z01MH001092)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
decision evaluation, single-unit activity, macaque, working memory
MeSH terms
Action Potentials, Analysis of Variance, Animals, Attention, Brain Mapping, Conditioning, Operant, Cues, Decision Making, Discrimination Learning, Feedback, Macaca mulatta, Male, Memory, Short-Term, Neurons, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Reward, ROC Curve, Time Factors, Prefrontal Cortex

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