Anterior-posterior gradient of plasticity in primate prefrontal cortex
Open accessAbstract
The functional organization of the primate prefrontal cortex has been a matter of debate with some models speculating dorso-ventral and rostro-caudal specialization while others suggesting that information is represented dynamically by virtue of plasticity across the entire prefrontal cortex. To address functional properties and capacity for plasticity, we recorded from different prefrontal sub-regions and analyzed changes in responses following training in a spatial working memory task. This training induces more pronounced changes in anterior prefrontal regions, including increased firing rate during the delay period, selectivity, reliability, information for stimuli, representation of whether a test stimulus matched the remembered cue or not, and variability and correlation between neurons. Similar results are obtained for discrete subdivisions or when treating position along the anterior-posterior axis as a continuous variable. Our results reveal that anterior aspects of the lateral prefrontal cortex of non-human primates possess greater plasticity based on task demands.
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The fronto-parietal system might be inherently more flexible throughout the lifespan and thus more capable of taking on new cultural skills.
“The fronto-parietal system might be inherently more flexible throughout the lifespan and thus more capable of taking on new cultural skills (Riley et al., 2018).”
From Computer code comprehension shares neural resources with formal logical inference in the fronto-parietal network (2020) · cites this paper as Riley et al., 2018
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- Authors
- Riley, M. R., Qi, X.-L., Zhou, X., & Constantinidis, C.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Stanford University (US)
- Corresponding author
- Constantinidis, Christos
- Venue
- Nature Communications
- Published
- 2018-09-17
- Volume
- 9
- Issue
- 1
- Pages
- 3790-3790
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC6141600
- OpenAlex
- W2890050451
- Cited by
- 47
- References
- 62
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (R01 EY017077)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- prefrontal cortex, anterior-posterior gradient, neuroplasticity, spatial working memory, lateral prefrontal cortex, non-human primates, functional specialization, neuronal firing rate, delay period, neuronal selectivity, information representation, training-induced changes
- MeSH terms
- Animals, Behavior, Animal, Macaca mulatta, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuronal Plasticity, Neurons, Neurophysiology, Mental Recall, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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