Cited by 47Neural and Behavioral Psychology StudiesNeural dynamics and brain functionMemory and Neural Mechanisms

Anterior-posterior gradient of plasticity in primate prefrontal cortex

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Riley, Mitchell R., Qi, Xue-Lian, Zhou, Xin, Constantinidis, Christos·2018·Nature Communications

Abstract

The functional organization of the primate prefrontal cortex has been a matter of debate with some models speculating dorso-ventral and rostro-caudal specialization while others suggesting that information is represented dynamically by virtue of plasticity across the entire prefrontal cortex. To address functional properties and capacity for plasticity, we recorded from different prefrontal sub-regions and analyzed changes in responses following training in a spatial working memory task. This training induces more pronounced changes in anterior prefrontal regions, including increased firing rate during the delay period, selectivity, reliability, information for stimuli, representation of whether a test stimulus matched the remembered cue or not, and variability and correlation between neurons. Similar results are obtained for discrete subdivisions or when treating position along the anterior-posterior axis as a continuous variable. Our results reveal that anterior aspects of the lateral prefrontal cortex of non-human primates possess greater plasticity based on task demands.

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Authors
Riley, M. R., Qi, X.-L., Zhou, X., & Constantinidis, C.
Affiliations
  • Atrium Health Wake Forest Baptist (US)
  • Stanford University (US)
Corresponding author
Constantinidis, Christos
Venue
Nature Communications
Published
2018-09-17
Volume
9
Issue
1
Pages
3790-3790
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2890050451
Cited by
47
References
62
Citations by year
2026: 4 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 4 · 2019: 3
FWCI
1.93
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
U.S. Department of Health & Human Services | National Institutes of Health (R01 EY017077)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
prefrontal cortex, anterior-posterior gradient, neuroplasticity, spatial working memory, lateral prefrontal cortex, non-human primates, functional specialization, neuronal firing rate, delay period, neuronal selectivity, information representation, training-induced changes
MeSH terms
Animals, Behavior, Animal, Macaca mulatta, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuronal Plasticity, Neurons, Neurophysiology, Mental Recall, Prefrontal Cortex

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