The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
A neural mechanism for exacerbation of headache by light
Open accessAbstract
The perception of migraine headache, which is mediated by nociceptive signals transmitted from the cranial dura mater to the brain, is uniquely exacerbated by exposure to light. We found that exacerbation of migraine headache by light is prevalent among blind individuals who maintain non-image-forming photoregulation in the face of massive rod/cone degeneration. Using single-unit recording and neural tract tracing in the rat, we identified dura-sensitive neurons in the posterior thalamus whose activity was distinctly modulated by light and whose axons projected extensively across layers I-V of somatosensory, visual and associative cortices. The cell bodies and dendrites of such dura/light-sensitive neurons were apposed by axons originating from retinal ganglion cells (RGCs), predominantly from intrinsically photosensitive RGCs, the principle conduit of non-image-forming photoregulation. We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In individuals with CM, central pain sensitization occurs between the full-blown attacks and could explain the low-grade headache, allodynia, and other symptoms that are characteristic of this disorder [72].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [72]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
The International Classification of Headache Disorders: 2nd edition
Olesen, J., Goadsby, P. J., & Steiner, T. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00590-8 · Cited by 5,046
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Mountcastle, V. B., Lynch, J. C., Georgopoulos, A., Sakata, H., & Acuna, C. (1975) · Journal of Neurophysiology · doi:10.1152/jn.1975.38.4.871 · Cited by 2,061
Anatomy and physiology of a color system in the primate visual cortex
Livingstone, M. S., & Hubel, D. H. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-01-00309.1984 · Cited by 1,637
Dacey, D. M., Liao, H.-W., Peterson, B. B., Robinson, F. R., Smith, V. C., Pokorny, J., Yau, K.-W., & Gamlin, P. D. (2005) · Nature · doi:10.1038/nature03387 · Cited by 1,333
A Novel Human Opsin in the Inner Retina
Provencio, I., Rodriguez, I. R., Jiang, G., Hayes, W. P., Moreira, E. F., & Rollag, M. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00600.2000 · Cited by 1,290
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
Flagged first, then by citations
Research works printed but not linked: 1
- Lowenfeld, I. The Dazzling Syndrome (Wane State University Press, Detroit, Michigan, USA, 1993).
Cited by
Sorted by citations
Items 501–568 of 568
Migraines and Cortical Spreading Depression
Dahlem, M. A. (2018) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-7320-6_507-7
Migraines and Cortical Spreading Depression
Dahlem, M. A. (2014) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-7320-6_507-6
A Great Conversation With Kathleen Digre
Seay, M. D., Calix, R. A., & Digre, K. B. (2023) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000001810
Self-citationInvolvement of Adipokines in Migraine Headache
Parker, K. K. (2011) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781849733434-00116
“My child seems to hate the bright light”
Ospina, L. H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-7020-6616-0.00094-3
Des innovations « anti-migraine » parmi les filtres thérapeutiques
Tiévant, C. (2023) · Revue Francophone d Orthoptie · doi:10.1016/j.rfo.2023.07.013
Ebrahim, A. A. E.-K. S., Rabee, M. O., Elshamy, A. M. B., Sherif, M. F., & Aboelsafa, A. A. (2023) · Journal of Advances in Medicine and Medical Research · doi:10.9734/jammr/2023/v35i195153
Melanopsin's Newly Identified Functions Related to Behavioral Light Adaptation
Shafiq, M. S. M. A., Mujawar, T., & Mansuri, M. S. (2023) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-13174
Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior
Yonk, A. J., Linares-García, I., Pasternak, L., Juliani, S. E., Gradwell, M. A., George, A. J., & Margolis, D. J. (2025) · eLife · doi:10.7554/elife.98563.3 · Cited by 1
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice BehaviorPreprint
Yonk, A. J., Linares-García, I., Pasternak, L., Juliani, S. E., Gradwell, M. A., George, A. J., & Margolis, D. J. (2024) · eLife · doi:10.7554/elife.98563.1
Şahan, M. H., Muluk, N. B., Koçtürk, F., & Akşamoğlu, M. (2024) · Romanian Journal of Rhinology · doi:10.2478/rjr-2024-0020
Refractive blur’s influence on discomfort glare perception from white LED headlights at night
Iizuka, T., Kawamorita, T., & Ishikawa, H. (2024) · Journal of the Optical Society of America A · doi:10.1364/josaa.534837
Park, J., Calligaro, H., Ibrahim, M. M., & Martin, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-24705-7.00031-4
Calcitonin gene-related peptide (CGRP) and its role in migraine
Day, A. S., & Ailani, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-24705-7.00007-7
Other Potential Clinical Uses of Precision Tinted Lenses
Wilkins, A. J., & Evans, B. J. W. (2024) · Springer eBooks · doi:10.1007/978-3-031-65568-5_11
Demirel, E., Berker, M., & Ünal-Çevik, I. (2024) · Neuro-Ophthalmology · doi:10.1080/01658107.2024.2430531
Role of Posterior Medial Thalamus in the Modulation of Striatal Circuitry and Choice BehaviorPreprint
Yonk, A. J., Linares-García, I., Pasternak, L., Juliani, S. E., Gradwell, M. A., George, A. J., & Margolis, D. J. (2025) · eLife · doi:10.7554/elife.98563.2
Inhibition of Posterior Thalamic Nuclei Attenuates CGRP-induced Migraine-like Behavior in MicePreprint
Greenway, A. M., Huebner, M. W., Waite, J. S., Flinn, H. C., Rea, B. J., Buxton, T. C., Duong, T. L., Wang, M., Uemura, H. L., Dorricott, N. O., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.03.641257
Findings on the association between hyperacusis and migraine
Goto, F., Wasano, K., Hamada, M., & Okami, K. (2025) · AUDIOLOGY JAPAN · doi:10.4295/audiology.68.42
Kaiser, E. A., Cavanah, A., Aguirre, G. K., & Jensen, F. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.24.655946
Raquin, M., Mrad, Y., Zkim, M. A., Dallel, R., Ranchon‐Cole, I., & Alba‐Delgado, C. (2025) · Headache The Journal of Head and Face Pain · doi:10.1111/head.15015
Hasegawa, A., Tagawa, Y., Shinmei, Y., Shinkai, A., & Ishida, S. (2025) · Cureus · doi:10.7759/cureus.91148
Migraine Trigger Factors and Wellness in Clinical Practice
Cuneo, A. Z., Riggins, N., Shaw, C., & Monteith, T. (2025) · Springer eBooks · doi:10.1007/978-3-031-86923-5_18
Effect of Light Wavelength on Corneal Sensitivity
Tresko, T. M., Feng, S., Buhr, E. D., Gelder, R. N. V., & Chou, B. W. (2025) · Ophthalmology Science · doi:10.1016/j.xops.2025.100993
The potential application of electrophysiological indicators in TMS treatment for MOH
Xiao, D., Han, H., Guo, H., Li, Z., He, Y., Ma, J., & Jiang, H. (2025) · Frontiers in Pain Research · doi:10.3389/fpain.2025.1689847
Photophobie : étiologies et physiopathologie
Bastelica, P., Baudouin, C., & Labbé, A. (2025) · Encyclopédie médico-chirurgicale. Ophtalmologie · doi:10.1016/s0246-0343(25)47233-5
Chen, Q., Wei, S., Jiang, G., Hu, X., Zhang, L., Li, P., & Han, J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1711571
Yang, C., Gong, Z., Zhang, X., Miao, S., Li, B., Xie, W., Wang, T., Han, X., Wang, L., Dong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591873
Fu, X., Chen, M., Lu, J., & Li, P. (2022) · Figshare · doi:10.6084/m9.figshare.19029590
Qiu, D., Wang, W., 梅岩良, Tang, H., Yuan, Z., Zhang, P., Zhang, Y., 于学英, Yang, C., Wang, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22697199
Fu, X., Chen, M., Lu, J., & Li, P. (2022) · Figshare · doi:10.6084/m9.figshare.19029587
Yang, C., Gong, Z., Zhang, X., Miao, S., Li, B., Xie, W., Wang, T., Han, X., Wang, L., Dong, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591870
Qiu, D., Wang, W., 梅岩良, Tang, H., Yuan, Z., Zhang, P., Zhang, Y., 于学英, Yang, C., Wang, Q., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22697202
Additional file 1 of Calcitonin gene-related peptide causes migraine aura
Al‐Khazali, H. M., Ashina, H., Wiggers, A., Rose, K., Iljazi, A., Christensen, R. H., Schytz, H. W., Amin, F. M., & Ashina, M. (2024) · Figshare · doi:10.6084/m9.figshare.26615554
Silva-Néto, R., & Digre, K. B. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33490-0.00018-1
Self-citationÖztürk, P., Öztürk, M. E., & Aktan, Ç. (2026) · Archives of Current Medical Research · doi:10.47482/acmr.1823908
Two Cases of Pediatric Migraine Relieved by Tinted Lenses that Reduced Photophobia
Kurihara, A., Hara, N., Kimijima, M., Gamo, M., & Ichibe, Y. (2025) · JAPANESE ORTHOPTIC JOURNAL · doi:10.4263/jorthoptic.55f112
Understanding Photophobia: A Neurophysiological Overview
Tashiro, A., & Kani, Y. (2025) · JAPANESE ORTHOPTIC JOURNAL · doi:10.4263/jorthoptic.55k001
Evaluation of the Efficacy of Tinted Lenses for Photophobia in Migraine Patients
Kimijima, M., & Hara, N. (2025) · JAPANESE ORTHOPTIC JOURNAL · doi:10.4263/jorthoptic.55s002
Rôles et régulations des canaux ioniques ASIC1b dans la douleur
Verkest, C. (2019) · theses.fr (ABES) · doi:10.70675/db17aabazd726z4d22zb273zf58b049ba711
Dynamics of attention and arousal in healthy and migraine populations
Masson, R. (2020) · theses.fr (ABES) · doi:10.70675/3bb511a1za582z4458za9d7z2bda595f8108
Shi, Z., Radu, S., Martenson, M., & Heinricher, M. M. (2026) · Neurobiology of Pain · doi:10.1016/j.ynpai.2026.100217
Topography of Photophobia: Perifoveal Sensitivity Associations in Glaucoma
Watanabe, T., Horiguchi, H., Honzawa, K., Nakadomari, S., Gunji, H., Aoyama, K., Amano, K., & Nakano, T. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.5.32
Changes in Melanopsin expression in the iris after corneal abrasion in an experimental rat model
Jenike, A., Zeimantz, S. O., Gunter, C., Jiang, C. L., Hegarty, D. M., Hilton, T., Matynia, A., Largent‐Milnes, T. M., Morgans, C. W., & Aicher, S. A. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111108
Electroretinography and pupillary response in migraine
Smith, C. C., Trivitt, S. F. H., Cummings, M. J., Thaxton, A. M., Key, L. V., Laycox, C. A., Crognale, M. A., & Haigh, S. M. (2026) · Headache The Journal of Head and Face Pain · doi:10.1111/head.70104
Early life stress induces brain-wide electrical network predisposition to migraine
Johnson, M., Eberle, M., Hultman, I., Zhang, X., Filali, Y., Hing, B. W. Q., Matkovich, M., Jimenez, A., Mitchell, S., Adegboyo, A., et al. (2026) · The Journal of Headache and Pain · doi:10.1186/s10194-026-02399-8
Retinal connections to migraine
Fila, M., Krekora, J., Dróżdż, J., Kaarniranta, K., & Błasiak, J. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1835914
Jin, Y., Wang, R., Huang, H., Ren, Z., & Yan, G. (2026) · Cephalalgia · doi:10.1177/03331024261462792
An orexinergic circuit driving migraine relief by lavender essential oil
Huang, H., Li, Y., Liu, A., Zhang, M., Wei, H.-R., Wu, R.-J., Yang, Y., Wang, X., Zhang, Z., Cao, P., et al. (2026) · Current Biology · doi:10.1016/j.cub.2026.06.040
Beyond migraine: A narrative review of photophobia's clinical spectrum
Doukhi, D., Vignal‐Clermont, C., & Mawet, J. (2026) · Revue Neurologique · doi:10.1016/j.neurol.2026.06.002
Akerman, S., Salinas-Abarca, A. B., Guo, W., Salvemini, D., & Romero‐Reyes, M. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70612
Tosta, S., Hewitt, G., & Anderson, A. K. (2026) · Brain Sciences · doi:10.3390/brainsci16080838
Haddad, E. N., Amin, R. S., Nero, N., Hogue, O., Rao, S., Sayegh, R. R., & Gopalakrishnan, R. (2026) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2026.08.005
Digital screen exposure and migraine burden: a systematic review and meta-analysis
Gowda, N. B., Harish, S., & Tej, G. (2026) · Journal of Neurology · doi:10.1007/s00415-026-14062-y
Casillo, F., Renzo, A. D., Sebastianelli, G., Abagnale, C., Martelli, F., Lorenzo, C. D., Ziccardi, L., Falsini, B., Parisi, V., & Coppola, G. (2026) · Cephalalgia · doi:10.1177/03331024261476232
Photophobie : étiologies et physiopathologie
Bastelica, P., Baudouin, C., & Labbé, A. (2026) · Journal Français d Ophtalmologie · doi:10.1016/j.jfo.2025.104725
Kagimoto, A., Okuda, S., Okajima, K., Tatsumoto, M., & Hirata, K. (2026) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2026.2736824
Pathophysiologie und Diagnostik kornealer neuropathischer Schmerzen
Ueberall, M. A., & Jacobi, C. (2026) · Schmerzmedizin · doi:10.1007/s00940-026-5193-9
Is photophobia associated with the structure of the visual thalamus? A MRI morphometric study
Coppola, G., Renzo, A. D., Sebastianelli, G., Giardina, I., Chiffi, D., Giuliani, G., Casillo, F., Abagnale, C., Ziccardi, L., Pucci, A., et al. (2026) · Neurological Sciences · doi:10.1007/s10072-026-09518-y
Andělová, M., Borsook, D., & Sprenger, T. (2015) · Headache · doi:10.1007/978-3-319-15621-7_6
Metadata
- Authors
- Noseda, R., Kainz, V., Jakubowski, M., Gooley, J. J., Saper, C. B., Digre, K., & Burstein, R.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Utah (US)
- Harvard University (US)
- Corresponding author
- Burstein, Rami
- Venue
- Nature Neuroscience
- Published
- 2010-01-10
- Volume
- 13
- Issue
- 2
- Pages
- 239-245
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2818758
- OpenAlex
- W2152412393
- Cited by
- 565
- References
- 46
- Citations by year
- 2026: 25 · 2025: 32 · 2024: 37 · 2023: 40 · 2022: 37 · 2021: 34 · 2020: 30 · 2019: 46 · 2018: 41 · 2017: 31 · 2016: 32 · 2015: 26 · 2014: 33 · 2013: 35 · 2012: 23
- FWCI
- 25.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS051484, NS-035611, R01NS033987, P01NS035611, NS051484)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- migraine, intrinsically photosensitive retinal ganglion cells, thalamus, thalamocortical neurons, blind people, nociceptive signaling, thalamocortical connections
- MeSH terms
- Adult, Animals, Axons, Blindness, Cerebral Cortex, Dendrites, Dura Mater, Female, Humans, Light, Male, Migraine Disorders, Neural Pathways, Neurons, Retina, Retinal Ganglion Cells, Thalamus, Incidence, Prevalence, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
