Cited by 568Migraine and Headache StudiesPain Mechanisms and TreatmentsCircadian rhythm and melatonin

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A neural mechanism for exacerbation of headache by light

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Noseda, Rodrigo, Kainz, Vanessa, Jakubowski, Moshe, Gooley, Joshua J, Saper, Clifford B, Digre, Kathleen, Burstein, Rami·2010·Nature Neuroscience

DOI 10.1038/nn.2475PMC PMC2818758

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Abstract

The perception of migraine headache, which is mediated by nociceptive signals transmitted from the cranial dura mater to the brain, is uniquely exacerbated by exposure to light. We found that exacerbation of migraine headache by light is prevalent among blind individuals who maintain non-image-forming photoregulation in the face of massive rod/cone degeneration. Using single-unit recording and neural tract tracing in the rat, we identified dura-sensitive neurons in the posterior thalamus whose activity was distinctly modulated by light and whose axons projected extensively across layers I-V of somatosensory, visual and associative cortices. The cell bodies and dendrites of such dura/light-sensitive neurons were apposed by axons originating from retinal ganglion cells (RGCs), predominantly from intrinsically photosensitive RGCs, the principle conduit of non-image-forming photoregulation. We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons.

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Authors: Noseda, R., Kainz, V., Jakubowski, M., Gooley, J. J., Saper, C. B., Digre, K., & Burstein, R.
Affiliations: Beth Israel Deaconess Medical Center (US)
University of Utah (US)
Harvard University (US)
Corresponding author: Burstein, Rami
ORCID: Noseda, Rodrigo
Jakubowski, Moshe
Gooley, Joshua J
Saper, Clifford B
Digre, Kathleen
Burstein, Rami
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-01-10
Volume: 13
Issue: 2
Pages: 239-245
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.2475
PMC: PMC2818758
OpenAlex: W2152412393
Cited by: 565
References: 46
Citations by year: 2026: 25 · 2025: 32 · 2024: 37 · 2023: 40 · 2022: 37 · 2021: 34 · 2020: 30 · 2019: 46 · 2018: 41 · 2017: 31 · 2016: 32 · 2015: 26 · 2014: 33 · 2013: 35 · 2012: 23
FWCI: 25.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS051484, NS-035611, R01NS033987, P01NS035611, NS051484)
Topics: Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: migraine, intrinsically photosensitive retinal ganglion cells, thalamus, thalamocortical neurons, blind people, nociceptive signaling, thalamocortical connections
MeSH terms: Adult, Animals, Axons, Blindness, Cerebral Cortex, Dendrites, Dura Mater, Female, Humans, Light, Male, Migraine Disorders, Neural Pathways, Neurons, Retina, Retinal Ganglion Cells, Thalamus, Incidence, Prevalence, Rats

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A neural mechanism for exacerbation of headache by light

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