Developmental Expression Patterns of GABAAReceptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex
Open accessAbstract
Cortical pyramidal neuron activity is regulated in part through inhibitory inputs mediated by GABAA receptors. The subunit composition of these receptors confers distinct functional properties. Thus, developmental shifts in subunit expression will likely influence the characteristics of pyramidal cell firing and the functional maturation of processes that depend on these neurons. We used laser microdissection and PCR to quantify postnatal developmental changes in the expression of GABAA receptor subunits (α1, α2, α5, β2, γ2, and δ) in layer 3 pyramidal cells of monkey prefrontal cortex, which are critical for working memory. To determine the specificity of these changes, we examined glutamate receptor subunits (AMPA Glur1 and NMDA Grin1) and conducted the same analyses in layer 5 pyramidal cells. Expression of GABAA receptor subunit mRNAs changed substantially, whereas glutamate receptor subunit changes were modest over postnatal development. Some transcripts (e.g., GABAA α1) progressively increased from birth until adulthood, whereas others (e.g., GABAA α2) declined with age. Changes in some transcripts were present in only one layer (e.g., GABAA δ). The development of GABAA receptor subunit expression in primate prefrontal pyramidal neurons is protracted and subunit- and layer-specific. These trajectories might contribute to the molecular basis for the maturation of working memory.
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The permissive depolarization of the postsynaptic density needed for NMDAR opening is provided by cholinergic stimulation of nicotinic α7 receptors in the postsynaptic density with only minor contributions from AMPA-type glutamate receptors.
“The permissive depolarization of the postsynaptic density needed for NMDAR opening is provided by cholinergic stimulation of nicotinic α7 receptors in the postsynaptic density11 with only minor contributions from AMPA-type glutamate receptors (AMPAR)10, consistent with the lower expression of AMPAR in layer III (ref. 12).”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [12]
These neurons are modulated in a more classical manner-for example, with a reliance on AMPAR actions-consistent with the higher expression of AMPAR in layer V of monkey dlPFC.
“These neurons are modulated in a more classical manner—for example, with a reliance on AMPAR actions10—consistent with the higher expression of AMPAR in layer V of monkey dlPFC12.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [12]
The expression of GABA receptor subunits on layer 3 and 5 pyramidal cells in macaque dlPFC changes substantially across postnatal development, with different subunits reaching maximal levels at ages ranging from perinatal to adult.
“Further, the expression of GABA receptor subunits on layer 3 and 5 pyramidal cells in macaque dlPFC changes substantially across postnatal development, with different subunits reaching maximal levels at ages ranging from perinatal to adult (Datta et al., 2015).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Datta et al., 2015
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- Authors
- Datta, D., Arion, D., & Lewis, D. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Datta, Dibyadeep
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-03-07
- Volume
- 25
- Issue
- 8
- Pages
- 2295-2305
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC4494034
- OpenAlex
- W2139503583
- Cited by
- 59
- References
- 73
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 4 · 2014: 1
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH051234, R01MH051234)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- GABAA receptor subunits, pyramidal neurons, prefrontal cortex, layer 3, layer 5, postnatal development, receptor maturation, glutamate receptor subunits, working memory, primate brain
- MeSH terms
- Aging, Animals, Female, Macaca mulatta, Male, Receptors, GABA-A, RNA, Messenger, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Pyramidal Cells, Receptors, AMPA, Real-Time Polymerase Chain Reaction, Laser Capture Microdissection
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