Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
Open accessAbstract
Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein parvalbumin (PV). Recent studies have revealed new facets of the development of PV neurons in primate neocortex and of the nature of their molecular alterations in individuals with schizophrenia. Other recent studies in model systems provide insight into how these alterations may arise in the course of cortical circuitry development.
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Interneurons have been implicated in schizophrenia, anxiety disorders, and autism.
“INs have also been implicated in other diseases including schizophrenia, anxiety disorders and autism”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Lewis, 2014
The section “Alterations in cortical PV neurons in schizophrenia” links changes in inhibitory neurons to schizophrenia. The passages from our copy do not address anxiety disorders or autism, so the citation supports only one of the three conditions named. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe modification of the E/I balance within the PV-circuitry in PV-/- mice is reminiscent of the situation in schizophrenia, where NMDA receptor hypofunction leads to the reduction of GAD67 levels and thus GABA synthesis.
“The modification of the E/I balance within the PV-circuitry in PV-/- mice is reminiscent of the situation in schizophrenia, where NMDA receptor hypofunction leads to the reduction of glutamic acid decarboxylase 67 (GAD67) levels and thus GABA synthesis.”
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- Authors
- Lewis, D. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Lewis, David A
- ORCID
- Lewis, David A
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 26
- Pages
- 22-26
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC4024332
- OpenAlex
- W2046537189
- Cited by
- 217
- References
- 51
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 22 · 2023: 5 · 2022: 14 · 2021: 17 · 2020: 11 · 2019: 34 · 2018: 17 · 2017: 20 · 2016: 31 · 2015: 28 · 2014: 5
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH043784, MH051234, R01MH051234, R37MH043784, MH043784)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- schizophrenia, parvalbumin neurons, GABAergic inhibition, cortical circuits, gamma oscillations, cognitive impairment, neocortex development, primate neocortex
- MeSH terms
- Cerebral Cortex, Cognition Disorders, gamma-Aminobutyric Acid, Humans, Nerve Net, Neural Inhibition, Parvalbumins, Schizophrenia
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