Cited by 363Pain Mechanisms and TreatmentsPain Management and TreatmentMusculoskeletal pain and rehabilitation

Pain vulnerability: a neurobiological perspective

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Denk, Franziska, McMahon, Stephen B, Tracey, Irene·2014·Nature Neuroscience

Abstract

There are many known risk factors for chronic pain conditions, yet the biological underpinnings that link these factors to abnormal processing of painful signals are only just beginning to be explored. This Review will discuss the potential mechanisms that have been proposed to underlie vulnerability and resilience toward developing chronic pain. Particular focus will be given to genetic and epigenetic processes, priming effects on a cellular level, and alterations in brain networks concerned with reward, motivation/learning and descending modulatory control. Although research in this area is still in its infancy, a better understanding of how pain vulnerability emerges has the potential to help identify individuals at risk and may open up new therapeutic avenues.

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  • A meta-analysis of 23 studies found that more than half of people diagnosed with TBI report chronic pain complaints, likely because of associated physical injuries at the time of TBI.

    “According to a metaanalysis of 23 studies, more than 50% of people diagnosed with TBI report chronic pain complaints 80, likely due to the associated physical injuries at the time of the TBI81.”

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Authors
Denk, F., McMahon, S. B., & Tracey, I.
Affiliations
  • King's College London (GB)
  • University of Oxford (GB)
Corresponding author
McMahon, Stephen B
Venue
Nature Neuroscience
Published
2014-01-28
Volume
17
Issue
2
Pages
192-200
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W2009740794
Cited by
363
References
103
Citations by year
2026: 18 · 2025: 24 · 2024: 26 · 2023: 22 · 2022: 31 · 2021: 29 · 2020: 28 · 2019: 38 · 2018: 37 · 2017: 36 · 2016: 32 · 2015: 28 · 2014: 14
FWCI
4.31
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion, other-oa)
Funders
Wellcome Trust (102645, 102645/Z/13/Z, 097903, 83259)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
Keywords
pain vulnerability, chronic pain, pain resilience, genetic risk factors, epigenetics, brain networks, descending pain modulation, reward and motivation, pain learning
MeSH terms
Animals, Humans, Neural Pathways, Neurobiology, Pain, Risk Factors, Epigenomics

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