Cited by 606Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Reliability and State Dependence of Pyramidal Cell–Interneuron Synapses in the Hippocampus

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Csicsvari, Jozsef, Hirase, Hajime, Czurko, Andras, Buzsáki, György·1998·Neuron

Abstract

Spike transmission probability between pyramidal cells and interneurons in the CA1 pyramidal layer was investigated in the behaving rat by the simultaneous recording of neuronal ensembles. Population synchrony was strongest during sharp wave (SPW) bursts. However, the increase was three times larger for pyramidal cells than for interneurons. The contribution of single pyramidal cells to the discharge of interneurons was often large (up to 0.6 probability), as assessed by the presence of significant (<3 ms) peaks in the cross-correlogram. Complex-spike bursts were more effective than single spikes. Single cell contribution was higher between SPW bursts than during SPWs or theta activity. Hence, single pyramidal cells can reliably discharge interneurons, and the probability of spike transmission is behavior dependent.

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Crossref · 10.1016/s0896-6273(00)80525-5

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Authors
Csicsvari, J., Hirase, H., Czurko, A., & Buzsáki, G.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
Buzsáki, György
Venue
Neuron
Publisher
Elsevier BV
Published
1998-07
Volume
21
Issue
1
Pages
179-189
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2027045997
Cited by
606
References
63
Citations by year
2026: 14 · 2025: 24 · 2024: 25 · 2023: 16 · 2022: 24 · 2021: 28 · 2020: 27 · 2019: 25 · 2018: 26 · 2017: 22 · 2016: 26 · 2015: 28 · 2014: 29 · 2013: 19 · 2012: 23
FWCI
11.34
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p41rr009754-09)
  • National Institute of Mental Health (R01MH054671, MH54671)
  • National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
  • National Center for Research Resources (1P41RR-09754)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
pyramidal neurons, interneurons, CA1, hippocampus, complex spikes, theta activity, population synchrony, cross-correlograms, state dependence, neuronal ensembles
MeSH terms
Action Potentials, Animals, Hippocampus, Interneurons, Male, Neural Pathways, Synaptic Transmission, Synapses, Time Factors, Rats, Sprague-Dawley, Pyramidal Cells, Rats

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