Reliability and State Dependence of Pyramidal Cell–Interneuron Synapses in the Hippocampus
Open accessAbstract
Spike transmission probability between pyramidal cells and interneurons in the CA1 pyramidal layer was investigated in the behaving rat by the simultaneous recording of neuronal ensembles. Population synchrony was strongest during sharp wave (SPW) bursts. However, the increase was three times larger for pyramidal cells than for interneurons. The contribution of single pyramidal cells to the discharge of interneurons was often large (up to 0.6 probability), as assessed by the presence of significant (<3 ms) peaks in the cross-correlogram. Complex-spike bursts were more effective than single spikes. Single cell contribution was higher between SPW bursts than during SPWs or theta activity. Hence, single pyramidal cells can reliably discharge interneurons, and the probability of spike transmission is behavior dependent.
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The pilocarpine model of temporal lobe epilepsy in adult mice shows an onset of recurrent spontaneous seizures 7 days after status epilepticus that can continue for at least 7 weeks.
“The pilocarpine model of TLE in adult mice shows an onset of recurrent spontaneous seizures 7 days after SE that can continue for at least 7 weeks [27, 34, 35].”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [27]
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“Since chronic recurrent seizures are a consequence of pilocarpine-induced SE in all adult mice [27, 34, 35]”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [27]
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Willems, J. G. P., Wadman, W. J., & Cappaert, N. L. M. (2018) · Hippocampus · doi:10.1002/hipo.22830 · Cited by 25 · see citing works
- Authors
- Csicsvari, J., Hirase, H., Czurko, A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Buzsáki, György
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 21
- Issue
- 1
- Pages
- 179-189
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2027045997
- Cited by
- 606
- References
- 63
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 25 · 2023: 16 · 2022: 24 · 2021: 28 · 2020: 27 · 2019: 25 · 2018: 26 · 2017: 22 · 2016: 26 · 2015: 28 · 2014: 29 · 2013: 19 · 2012: 23
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p41rr009754-09)
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- National Center for Research Resources (1P41RR-09754)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- pyramidal neurons, interneurons, CA1, hippocampus, complex spikes, theta activity, population synchrony, cross-correlograms, state dependence, neuronal ensembles
- MeSH terms
- Action Potentials, Animals, Hippocampus, Interneurons, Male, Neural Pathways, Synaptic Transmission, Synapses, Time Factors, Rats, Sprague-Dawley, Pyramidal Cells, Rats
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