Cited by 218Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Tasks for inhibitory interneurons in intact brain circuits

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Roux, Lisa, Buzsáki, György·2015·Neuropharmacology

Abstract

Synaptic inhibition, brought about by a rich variety of interneuron types, counters excitation, modulates the gain, timing, tuning, bursting properties of principal cell firing, and exerts selective filtering of synaptic excitation. At the network level, it allows for coordinating transient interactions among the principal cells to form cooperative assemblies for efficient transmission of information and routing of excitatory activity across networks, typically in the form of brain oscillations. Recent techniques based on targeted expression of neuronal activity modulators, such as optogenetics, allow physiological identification and perturbation of specific interneuron subtypes in the intact brain. Combined with large-scale recordings or imaging techniques, these approaches facilitate our understanding of the multiple roles of inhibitory interneurons in shaping circuit functions.

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Crossref · 10.1016/j.neuropharm.2014.09.011

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  • In the mammalian cerebral cortex, GABAergic interneurons regulate the balance and dynamic organization of pyramidal neuron ensembles, which mediate information processing streams and output channels.

    “In the mammalian cerebral cortex, GABAergic interneurons regulate the balance and dynamic organization of pyramidal neuron ensembles3, which in turn mediate myriad information processing streams and output channels4,5.”

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Authors
Roux, L., & Buzsáki, G.
Affiliations
New York University (US)
Corresponding author
Buzsáki, György
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2015-01
Volume
88
Pages
10-23
ISSN
0028-3908 (ISSN-L)
OpenAlex
W1994565921
Cited by
218
References
191
Citations by year
2026: 12 · 2025: 14 · 2024: 16 · 2023: 10 · 2022: 16 · 2021: 23 · 2020: 19 · 2019: 34 · 2018: 15 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 1
FWCI
2.25
Type
journal article
Language
en
Open access
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
  • National Institute of Health (NS34994, MH54671, NS074015)
  • Human Frontier Science Program (RGP0032/2011)
  • G. Harold and Leila Y. Mathers Charitable Foundation
  • J.D. McDonnell Foundation
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
inhibitory interneurons, synaptic inhibition, interneuron subtypes, neural oscillations, neural circuits, optogenetics, neuronal activity modulation, information transmission
MeSH terms
Animals, Brain, Interneurons, Neural Inhibition, Neural Pathways, Periodicity

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