Tasks for inhibitory interneurons in intact brain circuits
Open accessAbstract
Synaptic inhibition, brought about by a rich variety of interneuron types, counters excitation, modulates the gain, timing, tuning, bursting properties of principal cell firing, and exerts selective filtering of synaptic excitation. At the network level, it allows for coordinating transient interactions among the principal cells to form cooperative assemblies for efficient transmission of information and routing of excitatory activity across networks, typically in the form of brain oscillations. Recent techniques based on targeted expression of neuronal activity modulators, such as optogenetics, allow physiological identification and perturbation of specific interneuron subtypes in the intact brain. Combined with large-scale recordings or imaging techniques, these approaches facilitate our understanding of the multiple roles of inhibitory interneurons in shaping circuit functions.
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In the mammalian cerebral cortex, GABAergic interneurons regulate the balance and dynamic organization of pyramidal neuron ensembles, which mediate information processing streams and output channels.
“In the mammalian cerebral cortex, GABAergic interneurons regulate the balance and dynamic organization of pyramidal neuron ensembles3, which in turn mediate myriad information processing streams and output channels4,5.”
From The diversity of GABAergic neurons and neural communication elements (2019) · cites this paper as [3]
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- Authors
- Roux, L., & Buzsáki, G.
- Affiliations
- New York University (US)
- Corresponding author
- Buzsáki, György
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 88
- Pages
- 10-23
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC4254329
- OpenAlex
- W1994565921
- Cited by
- 218
- References
- 191
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 16 · 2023: 10 · 2022: 16 · 2021: 23 · 2020: 19 · 2019: 34 · 2018: 15 · 2017: 23 · 2016: 20 · 2015: 15 · 2014: 1
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Health (NS34994, MH54671, NS074015)
- Human Frontier Science Program (RGP0032/2011)
- G. Harold and Leila Y. Mathers Charitable Foundation
- J.D. McDonnell Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- inhibitory interneurons, synaptic inhibition, interneuron subtypes, neural oscillations, neural circuits, optogenetics, neuronal activity modulation, information transmission
- MeSH terms
- Animals, Brain, Interneurons, Neural Inhibition, Neural Pathways, Periodicity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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