Cited by 528Visual perception and processing mechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Partitioning neuronal variability

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Goris, Robbe L T, Movshon, J Anthony, Simoncelli, Eero P·2014·Nature Neuroscience

DOI 10.1038/nn.3711PMC PMC4135707

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Abstract

Responses of sensory neurons differ across repeated measurements. This variability is usually treated as stochasticity arising within neurons or neural circuits. However, some portion of the variability arises from fluctuations in excitability due to factors that are not purely sensory, such as arousal, attention and adaptation. To isolate these fluctuations, we developed a model in which spikes are generated by a Poisson process whose rate is the product of a drive that is sensory in origin and a gain summarizing stimulus-independent modulatory influences on excitability. This model provides an accurate account of response distributions of visual neurons in macaque lateral geniculate nucleus and cortical areas V1, V2 and MT, revealing that variability originates in large part from excitability fluctuations that are correlated over time and between neurons, and that increase in strength along the visual pathway. The model provides a parsimonious explanation for observed systematic dependencies of response variability and covariability on firing rate.

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Authors: Goris, R. L. T., Movshon, J. A., & Simoncelli, E. P.
Affiliations: New York University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Simoncelli, Eero P
ORCID: Goris, Robbe L T
Movshon, J Anthony
Simoncelli, Eero P
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-04-28
Volume: 17
Issue: 6
Pages: 858-865
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3711
PMC: PMC4135707
OpenAlex: W2035849979
Cited by: 528
References: 49
Citations by year: 2026: 54 · 2025: 41 · 2024: 43 · 2023: 30 · 2022: 31 · 2021: 32 · 2020: 39 · 2019: 61 · 2018: 48 · 2017: 49 · 2016: 50 · 2015: 42 · 2014: 8
FWCI: 25.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
Belgian American Educational Foundation
Vlaamse regering
National Institutes of Health
National Eye Institute (R37EY004440, EY022428, EY04440, R01EY004440, R01EY022428)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neural variability, action potential generation, sensory drive, Poisson process, gain modulation, lateral geniculate nucleus, primary visual cortex, visual pathway, firing rate, macaque
MeSH terms: Action Potentials, Animals, Female, Macaca fascicularis, Macaca mulatta, Macaca nemestrina, Male, Neurons, Photic Stimulation, Visual Cortex, Visual Pathways

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