The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Motivational activation: a unifying hypothesis of orexin/hypocretin function
Open accessAbstract
Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were originally thought to specifically mediate feeding and promote wakefulness, but it is now clear that they participate in a wide range of behavioral and physiological processes under select circumstances. Orexins primarily mediate behavior under situations of high motivational relevance, such as during physiological need states, exposure to threats or reward opportunities. We hypothesize that many behavioral functions of orexins (including regulation of sleep/wake cycling) reflect a fundamentally integrated function for orexins in translating motivational activation into organized suites of psychological and physiological processes supporting adaptive behaviors. We also discuss how numerous forms of neural heterogeneity modulate this function, allowing orexin neurons to organize diverse, adaptive responses in a variety of motivationally relevant situations. Thus, the involvement of orexins in diverse behaviors may reflect a common underlying function for this peptide system.
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Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
A role for lateral hypothalamic orexin neurons in reward seeking
Harris, G. C., Wimmer, M., & Aston-Jones, G. (2005) · Nature · doi:10.1038/nature04071 · Cited by 1,311
Self-citationThe neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276
Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., & de Lecea, L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3459-04.2004 · Cited by 462
Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction
Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5584-07.2008 · Cited by 234
Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity
Cason, A. M., Smith, R. J., Tahsili-Fahadan, P., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.009 · Cited by 229
Self-citationTupone, D., Madden, C. J., Cano, G., & Morrison, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3909-11.2011 · Cited by 228
Amygdala lesions reduce cataplexy in orexin knock-out mice
Burgess, C. R., Oishi, Y., Mochizuki, T., Peever, J. H., & Scammell, T. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5632-12.2013 · Cited by 108
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Neural Circuitry of Wakefulness and Sleep
Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415
Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior
Kirouac, G. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.005 · Cited by 357
“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346
Evidence that birds sleep in mid-flight
Rattenborg, N. C., Voirin, B., Cruz, S. M., Tisdale, R., Dell’Omo, G., Lipp, H.-P., Wikelski, M., & Vyssotski, A. L. (2016) · Nature Communications · doi:10.1038/ncomms12468 · Cited by 346
Metadata
- Authors
- Mahler, S. V., Moorman, D. E., Smith, R. J., James, M. H., & Aston-Jones, G.
- Venue
- Nature Neuroscience
- Published
- 2014-09-25
- Volume
- 17
- Issue
- 10
- Pages
- 1298-1303
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2058070208
- Cited by
- 385
- References
- 9
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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