An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis
Open accessAbstract
Orexin (hypocretin) neurons, located exclusively in the PeF-LH, which includes the perifornical area (PeF), the lateral hypothalamus (LH), and lateral portions of the medial hypothalamus, have widespread projections and influence many physiological functions, including the autonomic regulation of body temperature and energy metabolism. Narcolepsy is characterized by the loss of orexin neurons and by disrupted sleep, but also by dysregulation of body temperature and by a strong tendency for obesity. Heat production (thermogenesis) in brown adipose tissue (BAT) contributes to the maintenance of body temperature and, through energy consumption, to body weight regulation. We identified a neural substrate for the influence of orexin neurons on BAT thermogenesis in rat. Nanoinjection of orexin-A (12 pmol) into the rostral raphe pallidus (rRPa), the site of BAT sympathetic premotor neurons, produced large, sustained increases in BAT sympathetic outflow and in BAT thermogenesis. Activation of neurons in the PeF-LH also enhanced BAT thermogenesis over a long time course. Combining viral retrograde tracing from BAT, or cholera toxin subunit b tracing from rRPa, with orexin immunohistochemistry revealed synaptic connections to BAT from orexin neurons in PeF-LH and from rRPa neurons with closely apposed, varicose orexin fibers, as well as a direct, orexinergic projection from PeF-LH to rRPa. These results indicate a potent modulation of BAT thermogenesis by orexin released from the terminals of orexin neurons in PeF-LH directly into the rRPa and provide a potential mechanism contributing to the disrupted regulation of body temperature and energy metabolism in the absence of orexin.
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AMPK in the VMH and OX in the LHA modulate BAT thermogenesis.
“AMP-activated protein kinase (AMPK) in the ventromedial nucleus of the hypothalamus (VMH) and orexin (OX) in the lateral hypothalamic area (LHA) modulate brown adipose tissue (BAT) thermogenesis.”
From A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance (2016) · cites this paper as Tupone et al., 2011
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Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613 · see citing works
Hypocretin (orexin) deficiency in human narcolepsy
Nishino, S., Ripley, B., Overeem, S., Lammers, G. J., & Mignot, E. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05582-8 · Cited by 1,776 · see citing works
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works
Distribution of orexin receptor mRNA in the rat brain
Trivedi, P. G., Yu, H., MacNeil, D. J., der Ploeg, L. H. T. V., & Guan, X.-M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01266-6 · Cited by 979 · see citing works
Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-133546 · Cited by 725 · see citing works
Central neural pathways for thermoregulation
Shaun, F. M. (2010) · Frontiers in bioscience · doi:10.2741/3677 · Cited by 658 · see citing works
Fos Expression in Orexin Neurons Varies with Behavioral State
Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654 · see citing works
van den Pol, A. N., Gao, X., Obrietan, K. H., Kilduff, T. S., & Belousov, A. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07962.1998 · Cited by 552 · see citing works
A thermosensory pathway that controls body temperature
Nakamura, K., & Morrison, S. F. (2007) · Nature Neuroscience · doi:10.1038/nn2027 · Cited by 503 · see citing works
Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
Nishino, S., Ripley, B. A., Overeem, S., Nevšímalová, S., Lammers, G. J., Vaňková, J., Okun, M. L., Rogers, W. M., Brooks, S. N., & Mignot, E. J.-M. (2001) · Annals of Neurology · doi:10.1002/ana.1130 · Cited by 451 · see citing works
Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B. A., Matsumura, H., Yoneda, H., Mignot, E. J.-M., & Nishino, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01725.x · Cited by 449 · see citing works
Orexin (Hypocretin) Neurons Contain Dynorphin
Chou, T. C., Lee, C. E., Lü, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-j0003.2001 · Cited by 430 · see citing works
Behavioral State Instability in Orexin Knock-Out Mice
Mochizuki, T., Crocker, A. J., McCormack, S. L., Yanagisawa, M., Sakurai, T., & Scammell, T. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0586-04.2004 · Cited by 397 · see citing works
Brown Adipose Tissue in Morbidly Obese Subjects
Vijgen, G. H. E. J., Bouvy, N. D., Teule, G. J. J., Brans, B. T., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017247 · Cited by 374 · see citing works
Cano, G., Passerin, A. M., Schiltz, J. C., Card, J. P., Morrison, S. F., & Sved, A. F. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10643 · Cited by 337 · see citing works
Increased body-mass index in patients with narcolepsy
Schuld, A., Hebebrand, J., Geller, F., & Pollmächer, T. (2000) · The Lancet · doi:10.1016/s0140-6736(05)74704-8 · Cited by 331 · see citing works
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317 · see citing works
SB‐334867‐A: the first selective orexin‐1 receptor antagonist
Smart, D., Sabido-David, C., Brough, S. J., Jewitt, F., Johns, A., Porter, R. A., & Jerman, J. C. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703953 · Cited by 308 · see citing works
Nakamura, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1219-04.2004 · Cited by 295 · see citing works
Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep
Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M., & Sakurai, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6506-10.2011 · Cited by 268 · see citing works
Enhanced Orexin Receptor-2 Signaling Prevents Diet-Induced Obesity and Improves Leptin Sensitivity
Funato, H., Tsai, A. L., Willie, J. T., Kisanuki, Y. Y., Williams, S. C., Sakurai, T., & Yanagisawa, M. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.010 · Cited by 262 · see citing works
Hermann, D. M., Luppi, P., Peyron, C., Hinckel, P., & Jouvet, M. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)00019-7 · Cited by 260 · see citing works
Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function
Sellayah, D., Bharaj, P., & Sikder, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.010 · Cited by 259 · see citing works
Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2
Rosin, D. L., Weston, M. C., Sevigny, C. P., Stornetta, R. L., & Guyenet, P. G. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10860 · Cited by 252 · see citing works
Brown Fat and the Myth of Diet-Induced Thermogenesis
Kozak, L. P. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.009 · Cited by 243 · see citing works
Nakamura, K., & Morrison, S. F. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00427.2006 · Cited by 242 · see citing works
Central efferent pathways for cold-defensive and febrile shivering
Nakamura, K., & Morrison, S. F. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210047 · Cited by 238 · see citing works
Takahashi, K., Lin, J., & Sakai, K. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.058 · Cited by 235 · see citing works
Shiuchi, T., Haque, M. S., Okamoto, S., Inoue, T., Kageyama, H., Lee, S., Toda, C., Suzuki, A., Bachman, E. S., Kim, Y., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.013 · Cited by 225 · see citing works
Cao, W.-H., Fan, W., & Morrison, S. F. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.013 · Cited by 221 · see citing works
Morrison, S. F., Sved, A. F., & Passerin, A. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.2.r290 · Cited by 217 · see citing works
Chen, C.-T., Hwang, L.-L., Chang, J.-K., & Dun, N. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.3.r692 · Cited by 206 · see citing works
Hypocretin Deficiency in Narcoleptic Humans Is Associated with Abdominal Obesity
Kok, S. W., Overeem, S., Visscher, T. L. S., Lammers, G. J., Seidell, J. C., Pijl, H., & Meinders, A. E. (2003) · Obesity Research · doi:10.1038/oby.2003.156 · Cited by 202 · see citing works
The orexin system: roles in sleep/wake regulation
Sakurai, T., Mieda, M., & Tsujino, N. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05513.x · Cited by 199 · see citing works
Hara, J., Yanagisawa, M., & Sakurai, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.046 · Cited by 198 · see citing works
New Powers of Brown Fat: Fighting the Metabolic Syndrome
Nedergaard, J., Bengtsson, T., & Cannon, B. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.009 · Cited by 183 · see citing works
Ho, Y., Lee, H., Tung, L.-W., Liao, Y.-Y., Fu, S.-Y., Teng, S.-F., Liao, H.-T., Mackie, K., & Chiou, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2671-11.2011 · Cited by 180 · see citing works
Parallel preoptic pathways for thermoregulation
Yoshida, K., Li, X., Cano, G., Lazarus, M., & Saper, C. B. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2643-09.2009 · Cited by 160 · see citing works
Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats
Greco, M. A., & Shiromani, P. J. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00039-0 · Cited by 147 · see citing works
Orexin-A Regulates Body Temperature in Coordination with Arousal Status
Yoshimichi, G., Yoshimatsu, H., Masaki, T., & Sakata, T. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600513 · Cited by 138 · see citing works
Increased prevalence of obesity in narcoleptic patients and relatives
Dahmen, N., Bierbrauer, J., & Kasten, M. (2001) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060170057 · Cited by 138 · see citing works
Transneuronal Circuit Analysis With Pseudorabies Viruses
Card, J. P., & Enquist, L. W. (1999) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0105s09 · Cited by 135 · see citing works
Cao, W.-H., & Morrison, S. F. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02981-0 · Cited by 133 · see citing works
Orexin neurons are indispensable for stress-induced thermogenesis in mice
Zhang, W., Sunanaga, J., Takahashi, Y., Mori, T., Sakurai, T., Kanmura, Y., & Kuwaki, T. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.195099 · Cited by 128 · see citing works
Billig, I., Foris, J. M., Enquist, L. W., Card, J. P., & Yates, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07446.2000 · Cited by 128 · see citing works
Body Mass Index-Independent Metabolic Alterations in Narcolepsy with Cataplexy
Poli, F., Plazzi, G., Dalmazi, G. D., Ribichini, D., Vicennati, V., Pizza, F., Mignot, E. J.-M., Montagna, P., Pasquali, R., & Pagotto, U. (2009) · SLEEP · doi:10.1093/sleep/32.11.1491 · Cited by 126 · see citing works
Spontaneous Food Choice in Narcolepsy
Lammers, G. J., Pijl, H., Iestra, J. A., Langius, J. A. E., Buunk, G., & Meinders, A. E. (1996) · SLEEP · doi:10.1093/sleep/19.1.75 · Cited by 122 · see citing works
Berthoud, H., Patterson, L. M., Sutton, G. M., Morrison, C. D., & Zheng, H. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0761-x · Cited by 113 · see citing works
Morrison, S. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01227.2010 · Cited by 111 · see citing works
Novak, C. M., Kotz, C. M., & Levine, J. A. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00293.2005 · Cited by 110 · see citing works
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
Zhang, S., Zeitzer, J. M., Sakurai, T., Nishino, S., & Mignot, E. J.-M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129510 · Cited by 105 · see citing works
Madden, C. J., & Morrison, S. F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00527-x · Cited by 104 · see citing works
Transneuronal Circuit Analysis with Pseudorabies Viruses
Card, J. P., & Enquist, L. W. (2014) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0105s68 · Cited by 100 · see citing works
Ootsuka, Y., de Menezes, R. C. A., Zaretsky, D. V., Alimoradian, A., Hunt, J. L., Stefanidis, A., Oldfield, B. J., & Blessing, W. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.013 · Cited by 96 · see citing works
Serotonin potentiates sympathetic responses evoked by spinal NMDA
Madden, C. J., & Morrison, S. F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116574 · Cited by 96 · see citing works
Peever, J. H., Lai, Y., & Siegel, J. M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00968.2002 · Cited by 95 · see citing works
Samuels, B. C., Zaretsky, D. V., & DiMicco, J. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00667.2003 · Cited by 93 · see citing works
Orexin links emotional stress to autonomic functions
Kuwaki, T. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.08.004 · Cited by 88 · see citing works
Machado, B. H., Bonagamba, L. G. H., Dun, S. L., Kwok, E. H., & Dun, N. J. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00351-2 · Cited by 87 · see citing works
Elevated body temperature during sleep in orexin knockout mice
Mochizuki, T., Klerman, E. B., Sakurai, T., & Scammell, T. E. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00887.2005 · Cited by 86 · see citing works
Autonomic disturbances in narcolepsy
Plazzi, G., Moghadam, K. K., Maggi, L. S., Donadio, V. A., Vetrugno, R., Liguori, R., Zoccoli, G., Poli, F., Pizza, F., Pagotto, U., et al. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.05.002 · Cited by 83 · see citing works
Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis
Cerri, M., & Morrison, S. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.039 · Cited by 83 · see citing works
Ultrastructure of the stomatogastric ganglion neuropil of the crab, Cancer borealis
Kilman, V. L., & Marder, E. E. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961021)374:3 · Cited by 81 · see citing works
Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla
Ciriello, J., Li, Z., & de Oliveira, C. V. R. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.008 · Cited by 75 · see citing works
Raphe pallidus and parapyramidal neurons regulate ear pinna vascular conductance in the rabbit
Blessing, W. W., Yu, Y. H., & Nalivaiko, E. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00459-0 · Cited by 72 · see citing works
The Endogenous Actions of Hypothalamic Peptides on Brown Adipose Tissue Thermogenesis in the Rat
Verty, A. N. A., Allen, A. M., & Oldfield, B. J. (2010) · Endocrinology · doi:10.1210/en.2009-1235 · Cited by 59 · see citing works
Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons
Llewellyn‐Smith, I. J., Martin, C. L., Marcus, J., Yanagisawa, M., Minson, J. B., & Scammell, T. E. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00770-5 · Cited by 59 · see citing works
Monda, M., Viggiano, A., Mondola, P., & Luca, V. D. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02606-3 · Cited by 58 · see citing works
The neuroendocrine basis of lactation-induced suppression of GnRH: Role of kisspeptin and leptin
Smith, M. S., True, C. A., & Grove, K. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.038 · Cited by 57 · see citing works
Ootsuka, Y., Blessing, W. W., & Nalivaiko, E. (2008) · Stress · doi:10.1080/10253890701638303 · Cited by 52 · see citing works
Middelkoop, H. A. M., Lammers, G. J., van Hilten, B. J., Ruwhof, C., Pijl, H., & KAMPHUISEN, H. A. C. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb02957.x · Cited by 49 · see citing works
Parodoxical effect of orexin A: hypophagia induced by hyperthermia
Monda, M., Viggiano, A., & Luca, V. D. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03953-7 · Cited by 47 · see citing works
Luong, L. N. L., & Carrive, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.073 · Cited by 46 · see citing works
Standish, A., Enquist, L. W., Miselis, R. R., & Schwaber, J. S. (1995) · Journal of NeuroVirology · doi:10.3109/13550289509111025 · Cited by 43 · see citing works
Relationship between clinical characteristics of narcolepsy and CSF orexin‐A levels
Nakamura, M., Kanbayashi, T., Sugiura, T., & Inoue, Y. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00870.x · Cited by 41 · see citing works
Madden, C. J., & Morrison, S. F. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.10.019 · Cited by 39 · see citing works
Bengtsson, M. W., Mäkelä, K. A., Sjöblom, M., Uotila, S. T. H., Åkerman, K. E. O., Herzig, K., & Flemström, G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00514.2006 · Cited by 35 · see citing works
Shibata, H., & Nagasaka, T. (1984) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.34.103 · Cited by 34 · see citing works
Obesity after genetic ablation of brown adipose tissue.
Hamann, A., Flier, J. S., & Lowell, B. B. (1998) · PubMed · Cited by 29 · see citing works
Blessing, W. W. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00808.2004 · Cited by 13 · see citing works
Dampney, R. A. L., Horiuchi, J., Carrive, P., & Dampney, R. A. L. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.05.206 · Cited by 2 · see citing works
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- Card JP Enquist LW Adolph KW The use of neurotropic herpesviruses for defining synaptically linked populations of neurons in the central nervous system. Methods in Molecular Genetics, Molecular Biology Techniques Part A 1994 363 382 Academic Press San Diego
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Regulation of Body Temperature by the Nervous System
Tan, C. L., & Knight, Z. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.022 · Cited by 798 · see citing works
Central Mechanisms for Thermoregulation
Morrison, S. F., & Nakamura, K. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114546 · Cited by 586 · see citing works
The Browning of White Adipose Tissue: Some Burning Issues
Nedergaard, J., & Cannon, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.005 · Cited by 500 · see citing works
Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure
Morrison, S. F., Madden, C. J., & Tupone, D. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.007 · Cited by 427 · see citing works
Motivational activation: a unifying hypothesis of orexin/hypocretin function
Mahler, S. V., Moorman, D. E., Smith, R. J., James, M. H., & Aston‐Jones, G. (2014) · Nature Neuroscience · doi:10.1038/nn.3810 · Cited by 385 · see citing works
Role of orexin in modulating arousal, feeding, and motivation
Tsujino, N., & Sakurai, T. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00028 · Cited by 259 · see citing works
Kataoka, N., Hioki, H., Kaneko, T., & Nakamura, K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.018 · Cited by 240 · see citing works
Inutsuka, A., & Yamanaka, A. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00018 · Cited by 244 · see citing works
Central neural control of thermoregulation and brown adipose tissue
Morrison, S. F. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.02.010 · Cited by 213 · see citing works
Rezai-Zadeh, K. P., Yu, S., Jiang, Y., Laque, A., Schwartzenburg, C., Morrison, C. D., Derbenev, A. V., Zsombok, A., & Münzberg, H. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.07.008 · Cited by 193 · see citing works
Central Control of Brown Adipose Tissue Thermogenesis
Morrison, S. F., Madden, C. J., & Tupone, D. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00005 · Cited by 189 · see citing works
Townsend, K. L., & Tseng, Y. (2012) · Adipocyte · doi:10.4161/adip.18951 · Cited by 173 · see citing works
Brain regulation of energy balance and body weight
Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168 · see citing works
Contreras, C., González, F., Fernø, J., Diéguez, C., Rahmouni, K., Nogueiras, R., & López, M. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.919727 · Cited by 163 · see citing works
Dampney, R. (2015) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00051.2015 · Cited by 155 · see citing works
Brown and Beige Adipose Tissues in Health and Disease
Rui, L. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170001 · Cited by 178 · see citing works
Tupone, D., Madden, C. J., & Morrison, S. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1980-13.2013 · Cited by 156 · see citing works
Xu, T., Yang, Y., Ward, R. J., Gao, L., & Liu, Y. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.025 · Cited by 158 · see citing works
Central Nervous System Regulation of Brown Adipose Tissue
Morrison, S. F., & Madden, C. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140013 · Cited by 151 · see citing works
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012
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A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
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Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons
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α2 Adrenergic Receptor-Mediated Inhibition of Thermogenesis
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Brown, J. A., Woodworth, H. L., & Leinninger, G. M. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00009 · Cited by 100 · see citing works
Szymusiak, R. S. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00020-5 · Cited by 107 · see citing works
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Contreras, C., Nogueiras, R., Diéguez, C., Medina‐Gómez, G., & López, M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.002 · Cited by 100 · see citing works
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway
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The role of the hypothalamus in modulation of respiration
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Orexin-A controls sympathetic activity and eating behavior
Messina, G., Dalia, C., Tafuri, D., Monda, V., Palmieri, F., Dato, A., Russo, A., Blasio, S. D., Messina, A., Luca, V. D., et al. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00997 · Cited by 95 · see citing works
Sheng, Z., Santiago, A. M., Thomas, M. P., & Routh, V. H. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.08.001 · Cited by 95 · see citing works
Orexin/hypocretin system and autonomic control
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Brown adipose tissue as an anti‐obesity tissue in humans
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Tupone, D., Madden, C. J., & Morrison, S. F. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00014 · Cited by 87 · see citing works
Anderson, G., Rodriguez, M., & Reiter, R. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215500 · Cited by 86 · see citing works
The Central Control of Energy Expenditure: Exploiting Torpor for Medical Applications
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Hypothalamic dopamine signalling regulates brown fat thermogenesis
Folgueira, C., Beiroa, D., Porteiro, B., Duquenne, M., Puighermanal, E., Fondevila, M. F., Barja-Fernández, S., Gallego, R., Hernández-Bautista, R., Castelao, C., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0099-7 · Cited by 77 · see citing works
Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity
Lee, J. H., Lin, L., Xu, P., Saito, K., Wei, Q., Meadows, A. G., Bongmba, O. Y. N., Pradhan, G., Zheng, H., Xu, Y., et al. (2016) · Diabetes · doi:10.2337/db15-1587 · Cited by 73 · see citing works
Hypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis
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Martire, V. L., Silvani, A., Bastianini, S., Berteotti, C., & Zoccoli, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047032 · Cited by 65 · see citing works
Histamine receptor signaling in energy homeostasis
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Food for thought: The role of appetitive peptides in age-related cognitive decline
Fadel, J. R., Jolivalt, C. G., & Reagan, L. P. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.009 · Cited by 62 · see citing works
Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Milbank, E., & López, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00830 · Cited by 62 · see citing works
Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
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Perez‐Leighton, C. E., Boland, K., Teske, J. A., Billington, C. J., & Kotz, C. M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00119.2012 · Cited by 59 · see citing works
Ventromedial hypothalamus glucose‐inhibited neurones: A role in glucose and energy homeostasis?
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Orexin, cardio-respiratory function, and hypertension
Li, A., & Nattie, E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00022 · Cited by 57 · see citing works
Shi, Z., Pelletier, N. E., Wong, J., Li, B., Sdrulla, A. D., Madden, C. J., Marks, D. L., & Brooks, V. L. (2020) · eLife · doi:10.7554/elife.55357 · Cited by 60 · see citing works
Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism
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Neural circuit for psychological stress-induced hyperthermia
Nakamura, K. (2015) · Temperature · doi:10.1080/23328940.2015.1070944 · Cited by 55 · see citing works
Neural Control of Energy Expenditure
Münzberg, H., Qualls‐Creekmore, E., Berthoud, H., Morrison, C. D., & Yu, S. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_33 · Cited by 53 · see citing works
Orexin, serotonin, and energy balance
Mavanji, V., Pomonis, B., & Kotz, C. M. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1536 · Cited by 53 · see citing works
Challenges in the development of therapeutics for narcolepsy
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Lee, S. J., Kirigiti, M. A., Lindsley, S. R., Loche, A., Madden, C. J., Morrison, S. F., Smith, M. S., & Grove, K. L. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23265 · Cited by 53 · see citing works
Xiao, X., Yeghiazaryan, G., Heß, S., Klemm, P., Sieben, A., Kleinridders, A., Morgan, D. A., Wunderlich, F. T., Rahmouni, K., Kong, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25380-2 · Cited by 55 · see citing works
Barna, B. F., Takakura, A. C. T., & Moreira, T. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.031 · Cited by 51 · see citing works
Peripherally administered orexin improves survival of mice with endotoxin shock
Ogawa, Y., Irukayama‐Tomobe, Y., Murakoshi, N., Kiyama, M., Ishikawa, Y., Hosokawa, N., Tominaga, H., Uchida, S., Kimura, S., Kanuka, M., et al. (2016) · eLife · doi:10.7554/elife.21055 · Cited by 51 · see citing works
Differential Roles of Each Orexin Receptor Signaling in Obesity
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Lkhagvasuren, B., Oka, T., Nakamura, Y., Hayashi, H., Sudo, N., & Nakamura, K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.047 · Cited by 50 · see citing works
Orexin modulates brown adipose tissue thermogenesis
Madden, C. J., Tupone, D., & Morrison, S. F. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2011-0066 · Cited by 49 · see citing works
Integration of sensory information via central thermoregulatory leptin targets
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Function and Dysfunction of Hypocretin/Orexin: An Energetics Point of View
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Orexin and Central Modulation of Cardiovascular and Respiratory Function
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Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review
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Morrison, S. F. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00017-5 · Cited by 43 · see citing works
Luong, L. N. L., & Carrive, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.073 · Cited by 46 · see citing works
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Hitrec, T., Luppi, M., Bastianini, S., Squarcio, F., Berteotti, C., Martire, V. L., Martelli, D., Occhinegro, A., Tupone, D., Zoccoli, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51841-2 · Cited by 46 · see citing works
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Takahashi, Y., Zhang, W., Sameshima, K., Kuroki, C., Matsumoto, A., Sunanaga, J., Kono, Y., Sakurai, T., Kanmura, Y., & Kuwaki, T. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.261271 · Cited by 43 · see citing works
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Sa, M., Yoo, E.-S., Koh, W., Park, M. G., Jang, H., Yang, Y. R., Bhalla, M., Lee, J., Lim, J., Won, W., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00877-w · Cited by 43 · see citing works
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Iigaya, K., Horiuchi, J., McDowall, L. M., Lam, A., Sediqi, Y., Polson, J. W., Carrive, P., & Dampney, R. A. L. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00263.2012 · Cited by 40 · see citing works
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Korim, W. S., Llewellyn‐Smith, I. J., & Verberne, A. J. M. (2015) · Endocrinology · doi:10.1210/en.2015-1712 · Cited by 39 · see citing works
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Monda, V., Salerno, M., Sessa, F., Bernardini, R., Valenzano, A. A., Marsala, G., Zammit, C., Avola, R., Carotenuto, M., Messina, G., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0865-z · Cited by 38 · see citing works
Trevizan‐Baú, P., Dhingra, R. R., Furuya, W. I., Stanić, D., Mazzone, S. B., & Dutschmann, M. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25091 · Cited by 37 · see citing works
Graebner, A. K., Iyer, M., & Carter, M. E. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00111 · Cited by 38 · see citing works
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Basheer, R., & Shukla, C. (2016) · Nature and Science of Sleep · doi:10.2147/nss.s62365 · Cited by 39 · see citing works
Darwinkel, A., Stanić, D., Booth, L. C., May, C. N., Lawrence, A. J., & Yao, S. T. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.027 · Cited by 36 · see citing works
Latifi, B., Adamantidis, A., Bassetti, C. L., & Schmidt, M. H. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00790 · Cited by 36 · see citing works
You, H., Chu, P., Guo, W., & Lu, B. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.013 · Cited by 36 · see citing works
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Fukushima, A., Kataoka, N., & Nakamura, K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111380 · Cited by 41 · see citing works
Papp, R. S. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00034 · Cited by 35 · see citing works
The retrotrapezoid nucleus and the neuromodulation of breathing
Moreira, T. S., Sobrinho, C. R., Falquetto, B., Oliveira, L. M., Lima, J. D., Mulkey, D. K., & Takakura, A. C. T. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00497.2020 · Cited by 35 · see citing works
Browning of white adipose tissue: role of hypothalamic signaling
Bi, S., & Li, L. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12258 · Cited by 35 · see citing works
da Conceição, E. P. S., Morrison, S. F., Cano, G., Chiavetta, P., & Tupone, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-74272-w · Cited by 33 · see citing works
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Shin, Y. O., Lee, J. B., Min, Y. K., & Yang, H. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.017 · Cited by 33 · see citing works
Role of orexin receptors in obesity: from cellular to behavioral evidence
Perez‐Leighton, C. E., Butterick-Peterson, T. A., Billington, C. J., & Kotz, C. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.30 · Cited by 33 · see citing works
Chowdhury, S., Hung, C. J., Izawa, S., Inutsuka, A., Kawamura, M., Kawashima, T., Bito, H., Imayoshi, I., Abe, M., Sakimura, K., et al. (2019) · eLife · doi:10.7554/elife.44927 · Cited by 32 · see citing works
Liu, L., Wang, Q., Liu, A., Lan, X., Huang, Y., Zhao, Z., Jie, H., Chen, J., & Zhao, Y. (2019) · ACS Omega · doi:10.1021/acsomega.9b03106 · Cited by 32 · see citing works
Tsuneoka, Y., & Funato, H. (2024) · eNeuro · doi:10.1523/eneuro.0474-23.2024 · Cited by 31 · see citing works
Cerri, M., Vecchio, F. D., Mastrotto, M., Luppi, M., Martelli, D., Perez, E., Tupone, D., Zamboni, G., & Amici, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112849 · Cited by 31 · see citing works
- Authors
- Tupone, D., Madden, C. J., Cano, G., & Morrison, S. F.
- Affiliations
- Oregon Health & Science University (US)
- University of Pittsburgh (US)
- Corresponding author
- Tupone, Domenico
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-11-02
- Volume
- 31
- Issue
- 44
- Pages
- 15944-15955
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3224674
- OpenAlex
- W2154434397
- Cited by
- 228
- References
- 92
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 19 · 2020: 15 · 2019: 19 · 2018: 24 · 2017: 14 · 2016: 17 · 2015: 18 · 2014: 26 · 2013: 26 · 2012: 20
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- National Science Foundation (0918867)
- American Heart Association
- National Institutes of Health (P40OD010996)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK082558, DK-082558)
- National Institute of Neurological Disorders and Stroke (NS040987, R01NS040987)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- orexin, perifornical hypothalamus, lateral hypothalamus, raphe pallidus, brown adipose tissue, thermogenesis, sympathetic outflow, thermoregulation, energy metabolism, narcolepsy, obesity, synaptic connectivity
- MeSH terms
- Orexins, Animals, Benzoxazoles, beta-Galactosidase, Body Temperature, Adipose Tissue, Brown, Cholera Toxin, Dose-Response Relationship, Drug, Globus Pallidus, Hypothalamus, Male, Microinjections, Naphthyridines, Neurons, Neuropeptides, Polystyrenes, Raphe Nuclei, Urea, N-Methylaspartate, Rats, Sprague-Dawley, Rats, Wistar, Gene Transfer Techniques, Neurotransmitter Agents, Excitatory Amino Acid Agonists, Thermogenesis, Intracellular Signaling Peptides and Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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