Memory trace replay: The shaping of memory consolidation by neuromodulation
Open accessAbstract
The consolidation of memories for places and events is thought to rely, at the network level, on the replay of spatially tuned neuronal firing patterns representing discrete places and spatial trajectories. This occurs in the hippocampal-entorhinal circuit during sharp wave ripple events (SWRs) that occur during sleep or rest. Here, we review theoretical models of lingering place cell excitability and behaviorally induced synaptic plasticity within cell assemblies to explain which sequences or places are replayed. We further provide new insights into how fluctuations in cholinergic tone during different behavioral states might shape the direction of replay and how dopaminergic release in response to novelty or reward can modulate which cell assemblies are replayed.
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The specific form of memory replay and synaptic plasticity arising in adversarial learning may be induced through differential activation of neuromodulators, as observed during transition across sleep stages and in shaping memory replay in general.
“The specific form of memory replay and synaptic plasticity arising in adversarial learning may be induced through differential activation of neuromodulators, as it is also observed during the transition across sleep stages [47], and in shaping memory replay in general [48].”
From How Adversarial REM Dreams May Facilitate Creativity, and Why We Become Aware of Them (2024) · cites this paper as [48]
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- Authors
- Atherton, L. A., Dupret, D., & Mellor, J. R.
- Affiliations
- University of Bristol (GB)
- University of Oxford (GB)
- Corresponding author
- Atherton, Laura A.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 38
- Issue
- 9
- Pages
- 560-570
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC4712256
- OpenAlex
- W1900041959
- Cited by
- 180
- References
- 130
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 16 · 2023: 12 · 2022: 17 · 2021: 18 · 2020: 17 · 2019: 20 · 2018: 22 · 2017: 21 · 2016: 10 · 2015: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Trends in Neurosciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion, cc-by)
- Explore Bristol Research (submittedVersion, cc-by)
- Funders
- Eli Lilly and Company
- Wellcome Trust (101029/Z/13/Z, 101029)
- Directorate for Biological Sciences
- Medical Research Council (MC_UU_12024/3)
- Engineering and Physical Sciences Research Council (1280505)
- Biotechnology and Biological Sciences Research Council (BB/K000454/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- memory consolidation, memory replay, sharp-wave ripples, place cells, spatial firing patterns, cholinergic modulation, synaptic plasticity, cell assemblies, sleep, novelty, reward, neuromodulation
- MeSH terms
- Memory Consolidation, Animals, Brain, Humans, Neuronal Plasticity
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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