Neural reactivations during sleep determine network credit assignment
Open accessAbstract
A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem. Using neuroprosthetic learning, in which we could control the causal relationship between neurons and behavior, we found that sleep-dependent processing was required for credit assignment and the establishment of task-related functional connectivity reflecting the casual neuron–behavior relationship. Notably, we observed a strong link between the microstructure of sleep reactivations and credit assignment, with downscaling of non-causal activity. Decoupling of spiking to slow oscillations using optogenetic methods eliminated rescaling. Thus, our results suggest that coordinated firing during sleep is essential for establishing sparse activation patterns that reflect the causal neuron-behavior relationship.
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Reactivations in extrahippocampal/cortical areas tend to coincide with oscillatory hallmarks of memory consolidation during sleep, such as SOs and spindles, and with hippocampal SPW-Rs.
“Reactivations in extrahippocampal/cortical areas tend to coincide with oscillatory hallmarks of memory consolidation during sleep, such as SOs and spindles, 65,88,90,96 but also with hippocampal SPW-Rs, 96,99,101,103”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [90]
The Results section (‘Changes in Functional Coupling During Sleep’; page unavailable) says cortical reactivation events are tightly related to slow oscillations. The Discussion (‘Neuroprosthetic Memory Consolidation and Slow Oscillations’; page unavailable) says spindles occur with activity during slow-oscillation UP states and notes a link between cortical slow oscillations and hippocampal ripples. It does not establish that the cortical reactivations themselves coincide with spindles or hippocampal sharp-wave ripples. (LLM, conf=0.86)
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- Authors
- Gulati, T., Guo, L., Ramanathan, D. S., Bodepudi, A., & Ganguly, K.
- Affiliations
- San Francisco VA Medical Center (US)
- Corresponding author
- Ganguly, Karunesh
- Venue
- Nature Neuroscience
- Published
- 2017-07-10
- Volume
- 20
- Issue
- 9
- Pages
- 1277-1284
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5808917
- OpenAlex
- W2734327425
- Semantic Scholar
- ef75220a0784788969e19ffc30016d9b81ab2e3b
- Cited by
- 114
- References
- 49
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 11 · 2023: 12 · 2022: 11 · 2021: 18 · 2020: 11 · 2019: 17 · 2018: 11 · 2017: 2
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2 BX003308, I01 RX001640)
- National Institute of Neurological Disorders and Stroke (K99NS097620, K02NS093014)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep-dependent memory consolidation, credit assignment, slow oscillations, motor learning, functional connectivity
- MeSH terms
- Action Potentials, Animals, Male, Motor Cortex, Nerve Net, Neurons, Sleep, Rats, Long-Evans, Rats, Optogenetics
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