Stress and the brain: Individual variability and the inverted-U
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The distinction between threat and challenge offers a way for researchers to interpret how the same stressor might be harmful for some but not all people, and that some stressors might in fact be beneficial.
“This distinction between threat and challenge offers a way for researchers to interpret how the same stressor might be harmful for some but not all people, and that some stressors might in fact be beneficial (Sapolsky, 2015; Seery et al., 2010).”
From More than a feeling: A unified view of stress measurement for population science (2018) · cites this paper as Sapolsky, 2015
Cites
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More than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077 · see citing works
“challenge offers a way for researchers to interpret how the same stressor might be harmful for some but not all people, and that some stressors might in fact be beneficial (Sapolsky, 2015; Seery et al., 2010).”
BackgroundEarly life stress and development: potential mechanisms for adverse outcomes
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“…disease processes can not only originate from the molecular level and spread “bottom-up,” causing cellular and circuit-level disturbances; in addition, the reverse (topdown) direction and the ubiquitous existence of reciprocal brain-body interactions are well-established (Sapolsky, 2015).”
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Emotional Traumatic Brain Injury
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Sources of perceived stress in people with aphasia: a qualitative study
Jewell, C. C., Bergeron, K., Hunting Pompon, R., Pasque, P. A., & Harnish, S. M. (2026) · Aphasiology · doi:10.1080/02687038.2026.2646450 · Cited by 1 · see citing works
“Specifically, chronic stress may diminish activity in the prefrontal cortex and hippocampus, areas of the brain required for attention, executive functions, and memory – all necessary for aphasia rehabilitation and recovery (Davidson & McEwen, 2012; Sapolsky, 2015).”
- Authors
- Sapolsky, R. M.
- Affiliations
- Stanford University (US)
- Corresponding author
- Sapolsky, Robert M
- ORCID
- Sapolsky, Robert M
- Venue
- Nature Neuroscience
- Published
- 2015-09-25
- Volume
- 18
- Issue
- 10
- Pages
- 1344-1346
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1824821999
- Cited by
- 413
- References
- 20
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 47 · 2023: 50 · 2022: 46 · 2021: 34 · 2020: 48 · 2019: 33 · 2018: 40 · 2017: 30 · 2016: 22
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- stress, neurobiology of stress, interindividual variability, inverted-U curve, stress response, cognition, affect, behavior
- MeSH terms
- Animals, Brain, Humans, Stress, Psychological
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