Relationship between psychosocial stress-induced prefrontal cortex activity and gut microbiota in healthy participants-a functional near-infrared spectroscopy study
Open accessAbstract
Brain and gut microbes communicate in a bidirectional manner with each affecting a person's response to psychosocial stress. Although human studies demonstrated that the intake of probiotics can alter stress-related behavior in both patients and healthy participants, the association between stress-related brain functions and the gut microbiota has mostly been investigated in patients with depression. However, the response to psychosocial stress differs, even among healthy individuals, and elucidating the natural state of the gut microbiota would broaden the understanding of responses to psychosocial stress. We investigated the relationship between psychosocial stress response in the prefrontal cortex and the abundance of gut microbes in healthy male participants. The participants were exposed to psychosocial stress during a task while brain activation data were recorded using functional near-infrared spectroscopy. The heart rate and subjective stress were recorded, and fecal samples were collected. The stressful condition was accompanied by high subjective stress, high heart rate, and higher prefrontal activation in the right pre-motor cortex/supplementary motor area, right dorsolateral prefrontal cortex, right frontal pole, and right inferior prefrontal gyrus. The psychosocial stress response in the prefrontal cortex was also associated with changes in the gut microbiota abundance. The abundance of Alistipes , Clostridium IV , Clostridium XI , Faecalibacterium , and Blautia in healthy participants who had high psychosocial stress resembled that noted in patients with depression. These results suggest that the gut microbiota differs, among healthy participants, depending on the psychosocial stress response. We believe that this study is the first to report a direct relationship between brain function and the gut microbiota in healthy participants, and our findings would shed a new light on this field in the near future.
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Healthy participants with higher stress responses have an increased abundance of microbes found to be associated with depression.
“They found that the prefrontal cortex stress response correlated with the relative abundance of GM microbes, and that healthy participants with higher stress responses had an increased abundance of microbes found to be associated with depression.”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [495]
In healthy subjects, prefrontal cortex stress response correlates with the relative abundance of GM microbes.
“They found that the prefrontal cortex stress response correlated with the relative abundance of GM microbes, and that healthy participants with higher stress responses had an increased abundance of microbes found to be associated with depression.”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [495]
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Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
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- Authors
- Yamaoka, K., Uotsu, N., & Hoshino, E.
- Affiliations
- Fancl Corporation (Japan) (JP)
- Keio University Global Research Institute (JP)
- Corresponding author
- Yamaoka, Kao
- ORCID
- Yamaoka, Kao
- Venue
- Neurobiology of Stress
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 20
- Pages
- 100479
- ISSN
- 2352-2895 (ISSN-L)
- PMC
- PMC9418982
- OpenAlex
- W4291124198
- Cited by
- 18
- References
- 79
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 3
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neurobiology of Stress (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- psychosocial stress, gut microbiota, prefrontal cortex, gut-brain axis, stress response, dorsolateral prefrontal cortex, supplementary motor area, heart rate, subjective stress, Alistipes, Clostridium, Faecalibacterium, Blautia, healthy individuals
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