Microglial brain region-dependent diversity and selective regional sensitivities to aging

Grabert, Kathleen, Michoel, Tom, Karavolos, Michail H, Clohisey, Sara, Baillie, J Kenneth, Stevens, Mark P, Freeman, Tom C, Summers, Kim M +1 more·2016·Nature Neuroscience
DOI 10.1038/nn.4222

Cited by (138)

Items 101–138 of 138

  1. Acute microglia ablation induces neurodegeneration in the somatosensory system
    Rubino, Stephen J., Mayo, Lior, Wimmer, Isabella, Siedler, Victoria, Brunner, Florian, Hametner, Simon, Madi, Asaf, Lanser, Amanda, Moreira, Thais, Donnelly, Dustin et al. · 2018 · Nature Communications
  2. A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease
    Patir, Anirudh, Shih, Barbara, McColl, Barry W., Freeman, Tom C. · 2019 · Glia
  3. White matter microglia heterogeneity in the CNS
    Amor, Sandra, McNamara, Niamh B., Gerrits, Emma, Marzin, Manuel C., Kooistra, Susanne M., Miron, Veronique E., Nutma, Erik · 2022 · Acta Neuropathologica
  4. Microglia communication: parallels between aging and Alzheimer's disease
    Udeochu, Joe C., Shea, Jeremy M., Villeda, Saul A. · 2016 · Clinical and Experimental Neuroimmunology
  5. A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
    Abdel-Haq, Reem, Schlachetzki, Johannes CM, Boktor, Joseph C, Cantu-Jungles, Thaisa M, Thron, Taren, Zhang, Mengying, Bostick, John W, Khazaei, Tahmineh, Chilakala, Sujatha, Morais, Livia H et al. · 2022 · eLife
  6. Senescent Microglia: The Key to the Ageing Brain?
    Greenwood, Eleanor K., Brown, David R. · 2021 · International Journal of Molecular Sciences
  7. The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of Pathology
    Simon, E., Obst, J., Gomez-Nicola, D. · 2019 · Neuroscience
  8. The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease
    Bonham, Luke W., Sirkis, Daniel W., Yokoyama, Jennifer S. · 2019 · Frontiers in Immunology
  9. Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
    Bryant, Annie G., Hu, Miwei, Carlyle, Becky C., Arnold, Steven E., Frosch, Matthew P., Das, Sudeshna, Hyman, Bradley T., Bennett, Rachel E. · 2020 · Frontiers in Neurology
  10. Interleukin 4 modulates microglia homeostasis and attenuates the early slowly progressive phase of amyotrophic lateral sclerosis
    Rossi, Chiara, Cusimano, Melania, Zambito, Martina, Finardi, Annamaria, Capotondo, Alessia, Garcia-Manteiga, Jose Manuel, Comi, Giancarlo, Furlan, Roberto, Martino, Gianvito, Muzio, Luca · 2018 · Cell Death & Disease
  11. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
    Datta, Dibyadeep, Leslie, Shannon N., Morozov, Yury M., Duque, Alvaro, Rakic, Pasko, van Dyck, Christopher H., Nairn, Angus C., Arnsten, Amy F. T. · 2020 · Journal of Neuroinflammation
  12. More than meets the eye: The role of microglia in healthy and diseased retina
    Murenu, Elisa, Gerhardt, Maximilian-Joachim, Biel, Martin, Michalakis, Stylianos · 2022 · Frontiers in Immunology
  13. IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
    Rivera-Escalera, Fátima, Pinney, Jonathan J., Owlett, Laura, Ahmed, Hoda, Thakar, Juilee, Olschowka, John A., Elliott, Michael R., O’Banion, M. Kerry · 2019 · Journal of Neuroinflammation
  14. cTag-PAPERCLIP Reveals Alternative Polyadenylation Promotes Cell-Type Specific Protein Diversity and Shifts Araf Isoforms with Microglia Activation
    Hwang, Hun-Way, Saito, Yuhki, Park, Christopher Y., Blachère, Nathalie E., Tajima, Yoko, Fak, John J., Zucker-Scharff, Ilana, Darnell, Robert B. · 2017 · Neuron
  15. Microbiota‐microglia connections in age‐related cognition decline
    Zhou, Rui, Qian, Shufang, Cho, William C. S., Zhou, Jinyun, Jin, Chentao, Zhong, Yan, Wang, Jing, Zhang, Xiaohui, Xu, Zhoujiao, Tian, Mei et al. · 2022 · Aging Cell
  16. Ischemia/reperfusion induces interferon stimulated gene expression in microglia
    McDonough, Ashley, Lee, Richard V., Noor, Shahani, Lee, Chungeun, Le, Thu, Iorga, Michael, Phillips, Jessica L.H., Murphy, Sean, Möller, Thomas, Weinstein, Jonathan R. · 2017 · The Journal of Neuroscience
  17. Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia
    Shi, Ligen, Rocha, Marcelo, Zhang, Wenting, Jiang, Ming, Li, Sicheng, Ye, Qing, Hassan, Sulaiman H, Liu, Liqiang, Adair, Maya N, Xu, Jing et al. · 2020 · Journal of Cerebral Blood Flow & Metabolism
  18. Accelerated inflammatory aging in Alzheimer’s disease and its relation to amyloid, tau, and cognition
    Cullen, Nicholas C., Mälarstig, A nders, Stomrud, Erik, Hansson, Oskar, Mattsson-Carlgren, Niklas · 2021 · Scientific Reports
  19. Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain
    Kiss, Tamas, Nyúl-Tóth, Ádám, DelFavero, Jordan, Balasubramanian, Priya, Tarantini, Stefano, Faakye, Janet, Gulej, Rafal, Ahire, Chetan, Ungvari, Anna, Yabluchanskiy, Andriy et al. · 2022 · GeroScience
  20. Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism
    Makarava, Natallia, Chang, Jennifer Chen-Yu, Molesworth, Kara, Baskakov, Ilia V. · 2020 · Neurobiology of Disease
  21. Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
    Uriarte Huarte, Oihane, Kyriakis, Dimitrios, Heurtaux, Tony, Pires-Afonso, Yolanda, Grzyb, Kamil, Halder, Rashi, Buttini, Manuel, Skupin, Alexander, Mittelbronn, Michel, Michelucci, Alessandro · 2021 · Frontiers in Immunology
  22. Development and maintenance of the brain’s immune toolkit: microglia and non-parenchymal brain macrophages
    Lopez‐Atalaya, Jose P., Askew, Katharine E., Sierra, Amanda, Gomez‐Nicola, Diego · 2018 · Developmental Neurobiology
  23. Isolation and Phenotyping of Adult Mouse Microglial Cells
    Grabert, Kathleen, McColl, Barry W. · 2018 · Methods in Molecular Biology
  24. Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis
    Plastini, Melanie J., Desu, Haritha L., Brambilla, Roberta · 2020 · Frontiers in Cellular Neuroscience
  25. Identification of distinct and age‐dependent p16<sup>High</sup> microglia subtypes
    Talma, Nynke, Gerrits, Emma, Wang, Boshi, Eggen, Bart J.L., Demaria, Marco · 2021 · Aging Cell
  26. Redefining Microglial Identity in Health and Disease at Single-Cell Resolution
    Provenzano, Francesca, Pérez, María José, Deleidi, Michela · 2021 · Trends in Molecular Medicine
  27. The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases
    Triviño, Juan José, von Bernhardi, Rommy · 2021 · Neurochemistry International
  28. Genetic Variants of Lipoprotein Lipase and Regulatory Factors Associated with Alzheimer’s Disease Risk
    D. Bruce, Kimberley, Tang, Maoping, Reigan, Philip, H. Eckel, Robert · 2020 · International Journal of Molecular Sciences
  29. Loss of microglial EED impairs synapse density, learning, and memory
    Wang, Ying-Ying, Deng, Yu-Sen, Dai, Shang-Kun, Mi, Ting-Wei, Li, Rui-Yang, Liu, Pei-Pei, Liu, Cong, He, Bao-Dong, He, Xuan-Cheng, Du, Hong-Zhen et al. · 2022 · Molecular Psychiatry
  30. The Effect of an α-7 Nicotinic Allosteric Modulator PNU120596 and NMDA Receptor Antagonist Memantine on Depressive-like Behavior Induced by LPS in Mice: The Involvement of Brain Microglia
    Alzarea, Sami, Abbas, Muzaffar, Ronan, Patrick J., Lutfy, Kabirullah, Rahman, Shafiqur · 2022 · Brain Sciences
  31. Loss of Homeostatic Microglia Signature in Prion Diseases
    Wang, Yue, Hartmann, Kristin, Thies, Edda, Mohammadi, Behnam, Altmeppen, Hermann, Sepulveda-Falla, Diego, Glatzel, Markus, Krasemann, Susanne · 2022 · Cells
  32. Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt–Jakob Disease Patients
    Areškevičiūtė, Aušrinė, Litman, Thomas, Broholm, Helle, Melchior, Linea C., Nielsen, Pia R., Green, Alison, Eriksen, Jens O., Smith, Colin, Lund, Eva L. · 2020 · International Journal of Molecular Sciences
  33. <scp>CNS</scp> macrophage contributions to myelin health
    Hoffmann, Alana, Miron, Veronique E. · 2024 · Immunological Reviews
  34. TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration
    Zhu, Keying, Liu, Yun, Min, Jin-Hong, Joshua, Vijay, Lin, Jianing, Li, Yue, Kreutzmann, Judith C., Guo, Yuxi, Xia, Wenlong, Mohammadi, Elyas et al. · 2026 · Nature Neuroscience
  35. Neurogenesis and Neuroinflammation in Dialogue: Mapping Gaps, Modulating Microglia, Rewiring Aging
    Tanaka, Masaru · 2026 · Cells
  36. Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous system
    Walsh, Alexander D., Stone, Sarrabeth, Freytag, Saskia, Aprico, Andrea, Kilpatrick, Trevor J., Ansell, Brendan R. E., Binder, Michele D. · 2023 · Communications Biology
  37. Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α
    Grubman, Alexandra, Choo, Xin Yi, Chew, Gabriel, Ouyang, John F., Sun, Guizhi, Croft, Nathan P., Rossello, Fernando J., Simmons, Rebecca, Buckberry, Sam, Landin, Dulce Vargas et al. · 2019
  38. Microglial states revisited: from homeostasis to disease
    Eggen, Bart J. L., Kooistra, Susanne M. · 2026 · Nature Reviews Neuroscience