The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.
Pericytes of the neurovascular unit: key functions and signaling pathways
Open accessAbstract
Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary venules. CNS pericytes are uniquely positioned in the neurovascular unit between endothelial cells, astrocytes and neurons. They integrate, coordinate and process signals from their neighboring cells to generate diverse functional responses that are critical for CNS functions in health and disease, including regulation of the blood-brain barrier permeability, angiogenesis, clearance of toxic metabolites, capillary hemodynamic responses, neuroinflammation and stem cell activity. Here we examine the key signaling pathways between pericytes and their neighboring endothelial cells, astrocytes and neurons that control neurovascular functions. We also review the role of pericytes in CNS disorders including rare monogenic diseases and complex neurological disorders such as Alzheimer's disease and brain tumors. Finally, we discuss directions for future studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“pericyte-derived angiopoietin acts on endothelial Tie2 receptor and maintains BBB function (26, 570, 648);”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Pericyte-endothelial interaction plays a key role in the establishment and maintenance of the BBB (27, 570, 648, 682).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
The cited source says what the claim attributes to it.
In the citing paper
“At the capillary level, BBB integrity is maintained by pericytes (28, 59, 130, 570).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
The cited source says what the claim attributes to it.
In the citing paper
“Pericytes share a common basement membrane with brain capillary endothelial cells (570).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
The cited source says what the claim attributes to it.
In the citing paper
“Pericytedeficient mouse models caused by aberrant PDGF-BB/ PDGFR𝛃 signaling (365, 419, 436, 570, 575) exhibit impaired BBB formation (28, 59, 130) and maintenance (59, 436).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
The cited source says what the claim attributes to it.
In the citing paper
“Despite a pronounced pro-angiogenic response, AD brains fail to mount an adequate angiogenic response to renew lost capillary networks likely due to the loss of the homeobox gene MEOX2 from endothelium (656), and ongoing pericyte degeneration (570).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [570]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice
Sagare, A. P., Bell, R. D., Zhao, Z., Ma, Q., Winkler, E. A., Ramanathan, A., & Zlokovic, B. V. (2013) · Nature Communications · doi:10.1038/ncomms3932 · Cited by 589
RetractedIliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936
Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872
Pericytes regulate the blood–brain barrier
Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–999 of 999
Pericyte loss leads to microvessel remodeling and nasal polyp formation
Cui, N., Zhu, X., Zhao, C., Meng, C., Sha, J., & Zhu, D. (2023) · Acta Oto-Laryngologica · doi:10.1080/00016489.2023.2276345 · Cited by 1
Pericytes as an Essential Part in Transwell Models of the BBB in Vitro
Mosiagina, A. I., Хилажева, Е. Д., & Morgun, A. V. (2023) · Tsitologiya · doi:10.31857/s0041377123020050 · Cited by 1
Tran, N. T., Hale, N., Maung, A. A. W., Wiersma, M., Walker, D. W., Polglase, G. R., Castillo-Meléndez, M., & Wong, F. Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03137-0 · Cited by 1
Modern view on the role of pericytes in the microcirculation
Михайлов, П. В., Муравьев, А. В., Tikhomirova, I. A., & Osetrov, I. A. (2024) · Regional blood circulation and microcirculation · doi:10.24884/1682-6655-2024-23-2-4-14 · Cited by 2
Melanoma Cell Adhesion Molecule (CD 146) in Endometrial Physiology and Disorder
Hilage, P., Damle, M. N., Sharma, R. K., & Joshi, M. G. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_826 · Cited by 2
An Overview of the Blood-Brain Barrier
Barichello, T., Generoso, J. S., & Dal‐Pizzol, F. (2025) · Neuromethods · doi:10.1007/978-1-0716-4474-4_1 · Cited by 1
Impact of HIV-1 TAT activation on retinal Müller glia: Implications for barrier properties
Khatak, K., Sankaranarayanan, K., & Chatterjee, N. (2025) · Journal of Biosciences · doi:10.1007/s12038-025-00507-5 · Cited by 1
The Role of Intra-tumor Hypoxia in Cancer Cells Immune Escape Mechanism
Farhangnia, P., Delbandi, A., Aghamohamadi, N., Safdarian, A. R., & Akbarpour, M. (2025) · Springer eBooks · doi:10.1007/978-3-032-00759-9_61 · Cited by 1
The Multifaceted Roles of Pituitary Pericytes in Health and Disease
Chen, X., Ke, X., Lu, Y., Miao, H., Duan, L., Yang, H., Pan, H., Gong, F., Wang, L., & Zhu, H. (2025) · Endocrinology · doi:10.1210/endocr/bqaf152 · Cited by 1
Directed vascularization in bone regeneration requires bone marrow reconstitution
Mehl, J., Thiele, T., Ellinghaus, A., Gerhardt, H., & Duda, G. N. (2025) · JBMR Plus · doi:10.1093/jbmrpl/ziaf162 · Cited by 1
Human Cyclophilins—An Emerging Class of Drug Targets
Jurkova, K., Navrátilová, H., Musílek, K., & Benek, O. (2025) · Medicinal Research Reviews · doi:10.1002/med.70021 · Cited by 1
PRRX1 Orchestrates Pericyte–Myofibroblast Transition in Pathological Retinal Fibrosis
Meng, Z., Liu, D., Hu, Y., Shi, W., Qiu, J., Chen, B., Meng, Y., Yan, B., Liang, Y., He, J., et al. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.14.24 · Cited by 1
The role of pericytes in glaucoma and their potential as drug targets
Eleiwa, T. K., Elhusseiny, A. M., ElSheikh, R. H., Oechsli, S., Raghavendra, A. J., Liu, Z., Hammer, D. X., & Saeedi, O. J. (2025) · Expert Review of Ophthalmology · doi:10.1080/17469899.2025.2594823 · Cited by 1
Huang, J., Fu, Z., & Ma, Z. (2025) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2025.111962 · Cited by 1
Mechanisms of parasite‐mediated disruption of brain vessels
Loira, L., Arroz‐Madeira, S., Franco, C. A., & Pereira, S. S. (2025) · FEBS Letters · doi:10.1002/1873-3468.70255 · Cited by 1
Apolipoprotein D, a Novel Ligand for CD36, Is Essential for Blood–Brain Barrier Integrity
Gong, C., Shi, P.-X., Huang, Y.-J., Dai, Y., Hu, L., Cheng, X., Zhang, S., He, M., Wang, J.-H., Meng, Z.-Y., et al. (2026) · Circulation · doi:10.1161/circulationaha.125.077356 · Cited by 1
IGF-1 ameliorates the blood brain barrier disruption induced by the neonatal hypoxia-ischemia
Zhong, R., Huang, H., Liang, J., Lai, W., Tan, Y., Liu, W., Yuan, B., He, Z., Tang, Y., Liu, T., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116323 · Cited by 1
Wang, A., Li, J., Liu, H., & Yue, D. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin42796 · Cited by 1
Han, G., Song, J., Wan, S., Ji, X., Zhou, D., & Meng, R. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70827 · Cited by 1
Junctions, Transporters, and Interactions of Endothelial Cells: Regulation by Ethanol
Mandyam, C. D., Vandekerkhoff, A., Jung, S., Kharidia, D., Ponomarev, I., & Kisby, B. R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062695 · Cited by 3
Function and Modulation of Sphingosine-1-Phosphate Receptors in the Central Nervous System
Gulliksen, E., Darsi, S., Haidarbaigi, L., Codispoti, L. J., Purohit, D. J., Jung, A., Chilamula, A., & Newton, J. C. (2026) · Receptors · doi:10.3390/receptors5010009 · Cited by 1
Li, S., Wei, S., Wang, L., Yu, T., Wang, H., Yang, S. B., Cao, W., & Zhang, X. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151452 · Cited by 1
Intracellular mitochondrial transfer in ischemic stroke: Mechanisms and therapeutic application
Fu, R., Zhao, Y., Li, Y., Zhang, Y., Wang, M., Wang, Z., Zhou, M.-S., & Liu, Y. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.03.037 · Cited by 2
A Microfluidic Framework for Neuroprotective Compound Triage Across Ischemia and Neurodegeneration
Anchimowicz, J., & Jakieła, S. (2026) · Molecules · doi:10.3390/molecules31101622 · Cited by 1
Friend or foe? Glial–vascular interactions in health and neurodegenerative disease
McQuaid, C., Sewell, M. D. E., & Montagne, A. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100143 · Cited by 1
Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases
Agarwal, S., Bankar, A., & Pérez, V. D. J. (2026) · Comprehensive physiology · doi:10.1002/cph4.70205 · Cited by 1
Li, W., Wei, J., Tan, C., Liu, X., & Chen, L. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1862571 · Cited by 1
A Brain-Targeted DNA Delivery Nanocarrier Modulator for Synergistic Therapy of Parkinson’s Disease
Cheng, Y., Zhai, L., Wang, H., Liao, B., Che, J., Ma, K., Huang, G., Pan, S., Yang, H., & Guan, Y. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c06170 · Cited by 1
Dissection of spatial hypoxic and inflammatory ecosystem in glioblastoma
Wu, L., Wu, G., Zhai, Y., Ren, C., Zhou, H., Shi, J., Liu, X., Zhang, Y., Huang, B., Xia, P., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218718 · Cited by 1
Recent advances and current limitations of vascular organoids
Yoon, N., Kim, S., & Park, J. (2026) · Organoid · doi:10.51335/organoid.2026.6.e6 · Cited by 1
Associations among cognitive performance, VCAM-1, and GFAP in black adults: The ARCHES study
Singh, R. K., Bekena, S., Walker, A. I. B., Zhu, Y., Trani, J., & Babulal, G. M. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.07.003 · Cited by 1
Szecskó, A., Párdi, K., Cui, Z., Porkoláb, G., Hoyk, Z., Kovács, C., Adegbite, J. F., Fodor, V., Cser, N. M., Dér, L., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70568 · Cited by 1
Yao, M., Liu, A., Xing, L., Song, J., Yang, Y., Yue, X., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103260 · Cited by 1
Impact of Obstructive Sleep Apnea on Blood–Brain Barrier Permeability and Membrane Proteins
Jarecki, D., Turkiewicz, S., Białasiewicz, P., Strzelecki, D., & Gabryelska, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156702 · Cited by 1
Molecular Systems Architecture of Fibrotic Lung Microenvironment in Idiopathic Pulmonary Fibrosis
Ayyadurai, V. A. S., Manoharan, Y., & Deonikar, P. (2026) · Cells · doi:10.3390/cells15151364 · Cited by 1
Tunneling nanotubes in the nervous system: The fourth pillar of brain connectivity
Budinger, D., & Heneka, M. T. (2026) · Neuron · doi:10.1016/j.neuron.2026.07.010 · Cited by 1
Guo, Q., Yao, Y., Ding, Y., Chen, L., Zhang, Q., Zhang, H., & Xue, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1899684 · Cited by 1
The Ticking of the Epigenetic Clock: Antipsychotic Drugs in Old Age
Sfera, A., Osorio, C. P., Inderias, L., & Cummings, M. A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00122 · Cited by 1
Physiology of Cerebral Blood Vessels
Lindauer, U. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803196-4.00001-1 · Cited by 1
Histological Constituents of the Nervous System
Weis, S., Sonnberger, M., Dunzinger, A., Voglmayr, E., Aichholzer, M., Kleiser, R., & Strasser, P. (2019) · Springer eBooks · doi:10.1007/978-3-7091-1544-2_10 · Cited by 1
Biology of Pericytes – Recent Advances: Role of Pericytes in Brain Metastasis
Morofuji, Y., Nakagawa, S., Fujimoto, T., Yamaguchi, S., Ujifuku, K., & Matsuo, T. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-62129-2_3 · Cited by 1
Bioinspired and Bioinstructive Surfaces to Control Mesenchymal Stem Cells
Witte, K., Luo, J., Walker, M., Cantini, M., Seib, F. P., & Salmerón‐Sánchez, M. (2021) · Royal Society of Chemistry eBooks · doi:10.1039/9781839161124-00301 · Cited by 1
Neurological perspectives on aging
Yemişçi, M., & Karataş, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98804-9.00011-6 · Cited by 1
Guylène, P. (2022) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000033 · Cited by 1
Proliferative diabetic retinopathy, a disease of pathologic angiogenesis and vasculogenesis
Li, W., & Zhang, J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-93064-2.00004-4 · Cited by 1
Blood brain barrier disruption following COVID-19 infection and neurological manifestations
Deshwal, S., Dhiman, N., & Sandhir, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15256-6.00005-2 · Cited by 1
TRP channels: a provocative rationalization for local Ca2+ control in arterial tone development
El‐Lakany, M. A., & Welsh, D. G. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1374730 · Cited by 1
Liu, Z. (2024) · Reproductive Biology · doi:10.1016/j.repbio.2024.100919 · Cited by 1
RetractedHayden, M. R. (2024) · Journal of Vascular Diseases · doi:10.3390/jvd3040033 · Cited by 3
Rossetti, G. M. K., Dunster, J. L., Sohail, A., Williams, B., Cox, K. M., Rawlings, S., Jewett, E., Benford, E., Lovegrove, J. A., Gibbins, J. M., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288405 · Cited by 1
Winkler, E. A., Birk, H. S., Burkhardt, J.-K., Chen, X., Yue, J. K., Guo, D. E., Rutledge, W. C., Lasker, G., Tihan, T., Chang, E. F., et al. (2017) · Neurosurgery · doi:10.1093/neuros/nyx417.381 · Cited by 1
Gelatinase-Mediated Impairment of Microvascular Beds in Cerebral Ischemia and Reperfusion Injury
Chen, S., Song, H., Cui, J., Shenker, J. I., Chen, Y., Sun, G. Y., Feng, H., & Gu, Z. (2018) · Springer series in translational stroke research · doi:10.1007/978-3-319-90194-7_1 · Cited by 1
The Intricacies of Bioprinting Vascular Structures
Rao, T. C. (2022) · International journal of high school research · doi:10.36838/v4i6.17 · Cited by 1
Zerebrale Mikroangiopathie: Fortschritte im Verständnis der Pathophysiologie
Henneicke, S., Meuth, S. G., & Schreiber, S. (2023) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-2190-8957 · Cited by 1
Jacobs, S., Slootjes, S. M., Verhulst, D., & Gille, M. (2021) · Revue Neurologique · doi:10.1016/j.neurol.2020.12.010 · Cited by 1
Mechanisms for Extracellular Matrix-Dependent Blood-Brain Barrier Dysfunction
Hoettles, B. A. (2021) · doi:10.18122/td/1903/boisestate · Cited by 1
Vitamin K and the Visual System: A Narrative ReviewPreprint
Mong, M. A. (2023) · Preprints.org · doi:10.20944/preprints202302.0049.v1 · Cited by 1
Bernard, M., Menet, R., Lecordier, S., & ElAli, A. (2023) · Research Square · doi:10.21203/rs.3.rs-3059240/v1 · Cited by 1
Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI micePreprint
Zhong, R., Xu, Y., Williams, J. W., & Li, L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.04.565659 · Cited by 1
Pericytes mediate neurovascular remodeling in chronic arterial hypertensionPreprint
Morton, L., Garza, A. P., Dębska–Vielhaber, G., Villafuerte, L. E., Henneicke, S., Arndt, P., Meuth, S. G., Schreiber, S., & Dunay, I. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.13.594041 · Cited by 1
Engineered 3D Immuno-Glial-Neurovascular Human miBrain ModelPreprint
Tsai, L., Stanton, A. E., Bubnys, A., Agbas, E., James, B. T., Park, D. S., Jiang, A. Y. L., Pinals, R. L., Liu, L., Truong, N., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4577378/v1 · Cited by 1
Yousefi, M., Özkan, A., Özmen, K. K., Uysallı, Y., Mamipour, M., Akkaya, N., Amandi, A.-R. D., Atbaşi, A., Heidarzadeh, M., Erdener, Ş. E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.17.638582 · Cited by 1
Wei, B., Stitt, A. W., & Little, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.24.684393 · Cited by 1
Ahmadpour, D. (2021) · theses.fr (ABES) · doi:10.70675/cf02a85cz66d4z4c79za98czb8e4497ad04c · Cited by 1
Hoyer-Kimura, C. H., Huentelman, M. J., & Hay, M. (2026) · medRxiv · doi:10.64898/2026.05.06.26352482 · Cited by 1
Why Do Benign Tumors Hemorrhage?
Albert, G. W. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.08.056
Bhatt, A. A., & Brucker, J. L. (2017) · Journal of Pediatric Neurology · doi:10.1055/s-0037-1604218
Neurovascular unitと脳循環代謝：Update
髙橋愼一 (2018) · 神経治療学 · doi:10.15082/jsnt.35.3_163
New Pericytes in the Adult Brain Originate from a Previously Unrecognized Pericyte PrecursorPreprint
Kälin, R. E., Li, Y., Wu, Y., Eisenhut, K., Schmitt, L., Ziegenhain, C., Hellmann, I., Hou, M., Volmar, M. N. M., Schhller, U., et al. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3155612
Identifying New Therapeutics in Experimental Subarachnoid Hemorrhage
Tso, M. K. (2018) · TSpace (University of Toronto)
Inflammation in the early pathogenesis of diabetic retinopathy
Wang, S. (2018) · Purdue e-Pubs (Purdue University System) · doi:10.7912/c2/2205
Roles of type A pericytes in functional recovery from spinal cord injury
Ishii, T., & Muramatsu, R. (2019) · Folia Pharmacologica Japonica · doi:10.1254/fpj.153.249
Blood–brain barrier targeted nanoparticles
Obulesu, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819882-7.00003-9
Dysregulation of microRNAs in dementia
Gerardo-Aviles, J. (2019) · Bristol Research (University of Bristol)
The Blood–Brain Barrier in Cognitive Decline and Alzheimer’s Disease
Nation, D. A., & McIntosh, E. C. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190634230.003.0012
Emerging Mechanism of Cell Death Caused by Stroke: A Role of Neurovascular Unit
Ohtomo, R., & Arai, K. (2020) · Stroke revisited · doi:10.1007/978-981-10-1430-7_17
Brain susceptibility to hypoxia/hypoxemia and metabolic dysfunction in Alzheimer's disease
Baldassarro, V. A., Bighinati, A., Sannia, M., Giardino, L., & Calzà, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815868-5.00026-8
The pericyte progenitors and the pericytes are the ancestors of the inner ear structures
Davidoff, M. S. (2020) · International Bulletin of Otorhinolaryngology · doi:10.14748/orl.v16i2.6738
Early-life stress facilitates the development of Alzheimer’s disease pathology via angiopathyPreprint
Tanaka, T., Hirai, S., Hosokawa, M., Saito, T., Sakuma, H., Saido, T. C., Hasegawa, M., & Okado, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.27.062729
Grafting purified cortical pericytes into mouse motor cortex
Ganesh, M. G. (2020) · Otago University Research Archive (University of Otago)
Lee, W., Lyu, Z., Park, J., Kim, K.-M., Jin, H.-J., Wu, H., Rajadas, J., Kim, D., & Steinberg, G. K. (2021) · Research Square · doi:10.21203/rs.3.rs-96280/v1
Alarcón-Martínez, L., Küreli, G., & Dalkara, T. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-62129-2_5
Südy, R. (2020) · SZTE Repository of Dissertations (University of Szeged)
Blood–Brain Barrier Transporters and Central Nervous System Drug Response and Toxicity
Miller, D. W., Line, S., Safa, N. A., & Zhang, Y. (2021) · Wiley eBooks · doi:10.1002/9781119171003.ch12 · Cited by 1
Editorial: Application for Nanotechnology for the Treatment of Brain Diseases and Disorders
Li, J., Zheng, M., Zou, Y., Ke, P. C., Zhang, M., Banks, W. A., & Shi, B. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.743160
Mural Cells in the Brain Capillaries: Pericytes
Sun, R., Li, W., Gao, C., Zhang, J., & Shang, J. (2021) · Current Tissue Microenvironment Reports · doi:10.1007/s43152-021-00032-1
Liu, Y., Zhang, J., Bi, W., Zhou, M., Li, J., Xiong, T., Yang, N., Zhao, L., Tan, X., Chen, X., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-827730/v1
Hérault, Y. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733788062.793555435
Pattern recognition receptors and inflammasome activation in the blood-brain barrier
Nyúl‐Tóth, Á. (2018) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.9821
Novel aspects of diabetic complications
Südy, R. (2020) · doi:10.14232/phd.10644
The Blood-Brain Barrier in Stroke and Trauma and How to Enhance Drug Delivery
Keep, R. F., Xiang, J., Zhou, N., & Andjelkovic, A. V. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_23
Liu, Y., Zhang, J., Bi, W., Zhou, M., Li, J., Xiong, T., Yang, N., Zhao, L., Chen, X., Zhou, Y., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-827730/v2
Zhang, T., Liu, W., Yang, J., Xu, H., Sun, J., Liang, B., Cao, Y., Guo, L., Du, X., Chai, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1984984/v1
Research progress of brain injury after cardiopulmonary resuscitation
Yao, P., Ma, W., Wang, Z., Songling, T. A. N. G., Jian, M., Zhou, T., XIANG, X., Zhou, F., Gan, L., He, Y., et al. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0158
Metadata
- Authors
- Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V.
- Affiliations
- University of Southern California (US)
- Venue
- Nature Neuroscience
- Published
- 2016-05-26
- Volume
- 19
- Issue
- 6
- Pages
- 771-783
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5745011
- OpenAlex
- W2399776559
- Cited by
- 1,125
- References
- 175
- Citations by year
- 2026: 108 · 2025: 113 · 2024: 140 · 2023: 121 · 2022: 132 · 2021: 127 · 2020: 123 · 2019: 89 · 2018: 92 · 2017: 67 · 2016: 13
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG023084, R01AG039452, RF1AG039452)
- National Institute of Neurological Disorders and Stroke (R01NS090904, R01NS034467)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- pericytes, neurovascular unit, signaling pathways, blood-brain barrier permeability, angiogenesis, capillary hemodynamics, neuroinflammation, stem cell activity, Alzheimer's disease, brain tumors, central nervous system disorders
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Brain Diseases, Cerebrovascular Circulation, Humans, Signal Transduction, Pericytes, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
