Cited by 1,125Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsAngiogenesis and VEGF in Cancer

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Pericytes of the neurovascular unit: key functions and signaling pathways

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Sweeney, Melanie D, Ayyadurai, Shiva, Zlokovic, Berislav V·2016·Nature Neuroscience

DOI 10.1038/nn.4288PMC PMC5745011

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Abstract

Pericytes are vascular mural cells embedded in the basement membrane of blood microvessels. They extend their processes along capillaries, pre-capillary arterioles and post-capillary venules. CNS pericytes are uniquely positioned in the neurovascular unit between endothelial cells, astrocytes and neurons. They integrate, coordinate and process signals from their neighboring cells to generate diverse functional responses that are critical for CNS functions in health and disease, including regulation of the blood-brain barrier permeability, angiogenesis, clearance of toxic metabolites, capillary hemodynamic responses, neuroinflammation and stem cell activity. Here we examine the key signaling pathways between pericytes and their neighboring endothelial cells, astrocytes and neurons that control neurovascular functions. We also review the role of pericytes in CNS disorders including rare monogenic diseases and complex neurological disorders such as Alzheimer's disease and brain tumors. Finally, we discuss directions for future studies.

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Authors: Sweeney, M. D., Ayyadurai, S., & Zlokovic, B. V.
Affiliations: University of Southern California (US)
ORCID: Sweeney, Melanie D
Zlokovic, Berislav V
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2016-05-26
Volume: 19
Issue: 6
Pages: 771-783
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.4288
PMC: PMC5745011
OpenAlex: W2399776559
Cited by: 1,125
References: 175
Citations by year: 2026: 108 · 2025: 113 · 2024: 140 · 2023: 121 · 2022: 132 · 2021: 127 · 2020: 123 · 2019: 89 · 2018: 92 · 2017: 67 · 2016: 13
FWCI: 7.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG023084, R01AG039452, RF1AG039452)
National Institute of Neurological Disorders and Stroke (R01NS090904, R01NS034467)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: pericytes, neurovascular unit, signaling pathways, blood-brain barrier permeability, angiogenesis, capillary hemodynamics, neuroinflammation, stem cell activity, Alzheimer's disease, brain tumors, central nervous system disorders
MeSH terms: Animals, Blood-Brain Barrier, Brain, Brain Diseases, Cerebrovascular Circulation, Humans, Signal Transduction, Pericytes, Microvessels

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Pericytes of the neurovascular unit: key functions and signaling pathways

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