Pericytes of the neurovascular unit: key functions and signaling pathways

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

DeJesus-Hernandez, M., Mackenzie, I. R., Boeve, B. F., Boxer, A. L., Baker, M., Rutherford, N. J., Nicholson, A. M., Finch, N. A., Flynn, H., Adamson, J., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.011 · Cited by 4,936

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., & Ferrara, N. (1993) · Nature · doi:10.1038/362841a0 · Cited by 3,605

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124

Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653

Glial and neuronal control of brain blood flow

Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226

Pericytes are required for blood–brain barrier integrity during embryogenesis

Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102

Capillary pericytes regulate cerebral blood flow in health and disease

Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

Hellström, M., Phng, L.-K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., et al. (2007) · Nature · doi:10.1038/nature05571 · Cited by 1,775

Establishment and Dysfunction of the Blood-Brain Barrier

Zhao, Z., Nelson, A. R., Betsholtz, C., & Zlokovic, B. V. (2015) · Cell · doi:10.1016/j.cell.2015.10.067 · Cited by 1,670

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.043 · Cited by 1,448

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E. K., & Hanahan, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17929 · Cited by 1,361

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature · doi:10.1038/nature11087 · Cited by 1,293

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

Bergers, G., Song, S., Meyer-Morse, N., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317929 · Cited by 1,192

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1943 · Cited by 1,167

Glial regulation of the cerebral microvasculature

Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153

Bidirectional control of CNS capillary diameter by pericytes

Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150

Astrocyte-mediated control of cerebral blood flow

Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

Hellström, M., Gerhardt, H., Kalén, M., Li, X., Eriksson, U., Wolburg, H., & Betsholtz, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.543 · Cited by 1,132

Cerebral microvascular pathology in aging and Alzheimer's disease

Farkas, E., & Luiten, P. G. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00068-x · Cited by 1,102

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048

Mfsd2a is critical for the formation and function of the blood-brain barrier

Ben-Zvi, A., Lacoste, B., Kur, E., Andreone, B. J., Mayshar, Y., Yan, H., & Gu, C. (2014) · Nature · doi:10.1038/nature13324 · Cited by 1,037

Central nervous system pericytes in health and disease

Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2946 · Cited by 962

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesisPreprint

Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C., & Shima, D. T. (2002) · Genes & Development · doi:10.1101/gad.242002 · Cited by 918

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

Sato, Y., & Rifkin, D. B. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.309 · Cited by 908

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

Cheng, L., Huang, Z., Zhou, W., Wu, Q., Donnola, S., Liu, J. K., Fang, X., Sloan, A. E., Mao, Y., Lathia, J. D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.021 · Cited by 905

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

Yemişçi, M., Özdemir, Y., Vural, A., Can, A., Topalkara, K., & Dalkara, T. (2009) · Nature Medicine · doi:10.1038/nm.2022 · Cited by 805

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

Hill, R., Тонг, Л., Yuan, P., Murikinati, S. R., Gupta, S., & Grutzendler, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.001 · Cited by 738

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

Halliday, M. R., Rege, S. V., Ma, Q., Zhao, Z., Miller, C. A., Winkler, E. A., & Zlokovic, B. V. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.44 · Cited by 649

What is a pericyte?

Attwell, D., Mishra, A., Hall, C. N., O’Farrell, F. M., & Dalkara, T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15610340 · Cited by 648

A role for VEGF as a negative regulator of pericyte function and vessel maturation

Greenberg, J. I., Shields, D. J., Barillas, S. G., Acevedo, L. M., Murphy, E. A., Huang, J., Scheppke, L., Stockmann, C., Johnson, R. S., Angle, N., et al. (2008) · Nature · doi:10.1038/nature07424 · Cited by 638

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407290101 · Cited by 600

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

Blinder, P., Tsai, P. S., Kaufhold, J. P., Knutsen, P. M., Suhl, H., & Kleinfeld, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3426 · Cited by 573

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Davalos, D., Kyu Ryu, J., Merlini, M., Baeten, K. M., Le Moan, N., Petersen, M. A., Deerinck, T. J., Smirnoff, D. S., Bedard, C., Hakozaki, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2230 · Cited by 568

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

Lu, K. V., Chang, J. P., Parachoniak, C. A., Pandika, M. M., Aghi, M. K., Meyronet, D., Isachenko, N., Fouse, S. D., Phillips, J. J., Cheresh, D. A., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.037 · Cited by 566

Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in Alzheimer's Disease

Sengillo, J. D., Winkler, E. A., Walker, C. T., Sullivan, J. S., Johnson, M., & Zlokovic, B. V. (2013) · Brain Pathology · doi:10.1111/bpa.12004 · Cited by 553

PDGFRβ+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

Song, S., Ewald, A. J., Stallcup, W. B., Werb, Z., & Bergers, G. (2005) · Nature Cell Biology · doi:10.1038/ncb1288 · Cited by 551

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

DIAGRAM, Kooner, J. S., MuTHER, Saleheen, D., Sim, X., Sehmi, J., Zhang, W., Frossard, P., Been, L. F., Chia, K., et al. (2011) · Nature Genetics · doi:10.1038/ng.921 · Cited by 546

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutantsPreprint

Krebs, L. T., Shutter, J. R., Tanigaki, K., Honjo, T., Stark, K. L., & Gridley, T. (2004) · Genes & Development · doi:10.1101/gad.1239204 · Cited by 540

Targeting the PDGF signaling pathway in tumor treatment

Heldin, C. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-97 · Cited by 536

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513

High TGFβ-Smad Activity Confers Poor Prognosis in Glioma Patients and Promotes Cell Proliferation Depending on the Methylation of the PDGF-B Gene

Bruna, A., Darken, R. S., Rojo, F., Ocaña, A., Peñuelas, S., Arias, A., Parı́s, R., Tortosa, A., Mora, J., Baselga, J. M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.023 · Cited by 491

EndMT contributes to the onset and progression of cerebral cavernous malformations

Maddaluno, L., Rudini, N., Cuttano, R., Bravi, L., Giampietro, C., Corada, M., Ferrarini, L., Orsenigo, F., Papa, E., Boulday, G., et al. (2013) · Nature · doi:10.1038/nature12207 · Cited by 486

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Felcht, M., Luck, R., Schering, A., Seidel, P., Srivastava, K., Hu, J., Bartol, A., Kienast, Y., Vettel, C., Loos, E. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58832 · Cited by 479

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Zhong, Z., Deane, R., Ali, Z., Parisi, M., Shapovalov, Y., O'Banion, M. K., Stojanovic, K., Sagare, A., Boillee, S., Cleveland, D. W., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2073 · Cited by 476

Alzheimer’s Disease Genetics: From the Bench to the Clinic

Karch, C. M., Cruchaga, C., & Goate, A. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.041 · Cited by 473

Mutations within the Programmed Cell Death 10 Gene Cause Cerebral Cavernous Malformations

Bergametti, F., Denier, C., Labauge, P. M., Arnoult, M., Boetto, S., Clanet, M., Coubes, P. A., Échenne, B., Ibrahim, R., Irthum, B., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/426952 · Cited by 449

Astrocyte Regulation of Blood Flow in the BrainPreprint

MacVicar, B. A., & Newman, E. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020388 · Cited by 443

Ephrin-B2 Controls Cell Motility and Adhesion during Blood-Vessel-Wall Assembly

Foo, S. S. C., Turner, C. J., Adams, S., Compagni, A., Aubyn, D., Kogata, N., Lindblom, P., Shani, M., Zicha, D., & Adams, R. H. (2006) · Cell · doi:10.1016/j.cell.2005.10.034 · Cited by 439

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

Geraldes, P., Hiraoka‐Yamamoto, J., Matsumoto, M., Clermont, A. C., Leitges, M., Marette, A., Aiello, L. P., Kern, T. S., & King, G. L. (2009) · Nature Medicine · doi:10.1038/nm.2052 · Cited by 433

Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis

Wang, C., Li, Y., Shi, L., Ren, J., Patti, M., Wang, T., de Oliveira, J. R. M., Sobrido, M. J., Quintáns, B., Baquero, M., et al. (2012) · Nature Genetics · doi:10.1038/ng.1077 · Cited by 417

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

Fernández-Klett, F., Offenhauser, N., Dirnagl, U., Priller, J., & Lindauer, U. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011321108 · Cited by 399

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

Yuan, H. T., Khankin, E. V., Karumanchi, S. A., & Parikh, S. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01472-08 · Cited by 383

Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice

Goumans, M., & Mummery, C. L. (2000) · The International Journal of Developmental Biology · doi:10.1387/ijdb.10853822 · Cited by 376

Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils

Wang, S., Voisin, M.-B., Larbi, K. Y., Dangerfield, J. A., Scheiermann, C., Tran, M. G. B., Maxwell, P. H., Sorokin, L. M., & Nourshargh, S. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051210 · Cited by 374

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

Hawkes, C. A., Härtig, W., Kacza, J., Schliebs, R., Weller, R. O., Nicoll, J. A. R., & Carare, R. O. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0801-7 · Cited by 365

Ephrin-B2 Selectively Marks Arterial Vessels and Neovascularization Sites in the Adult, with Expression in Both Endothelial and Smooth-Muscle Cells

Gale, N. W., Bałuk, P., Pan, L., Kwan, M. L., Holash, J. A., DeChiara, T. M., McDonald, D. M., & Yancopoulos, G. D. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0112 · Cited by 363

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H., & Zlokovic, B. V. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1039-8 · Cited by 354

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling

Winkler, E. A., Bell, R. D., & Zloković, B. V. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-32 · Cited by 354

Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice

Hartmann, D. A., Underly, R. G., Grant, R. I., Watson, A. N., Lindner, V., & Shih, A. Y. (2015) · Neurophotonics · doi:10.1117/1.nph.2.4.041402 · Cited by 326

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice

Keller, A., Westenberger, A., Sobrido, M. J., García-Murias, M., Domingo, A., Sears, R. L., Lemos, R. R., Ordoñez-Ugalde, A., Nicolas, G., da Cunha, J. E. G., et al. (2013) · Nature Genetics · doi:10.1038/ng.2723 · Cited by 324

Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow

Gebremedhin, D., Lange, A. R., Lowry, T. F., Taheri, M. R., Birks, E. K., Hudetz, A. G., Narayanan, J., Falck, J. R., Okamoto, H., Roman, R. J., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.1.60 · Cited by 318

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

Franco, M., Roswall, P., Cortez, E., Hanahan, D., & Pietras, K. (2011) · Blood · doi:10.1182/blood-2011-01-331694 · Cited by 310

Two-photon imaging of capillary blood flow in olfactory bulb glomeruli

Chaigneau, E. M., Oheim, M., Audinat, É., & Charpak, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133652100 · Cited by 306

The Transforming Growth Factor‐βs

Bottner, M. B., KRIEGLSTEIN, K. G., & Unsicker, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752227.x · Cited by 302

Pericytes: Pluripotent Cells of the Blood Brain Barrier

Dore‐Duffy, P. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705469 · Cited by 292

Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex

Johnson, M. B., Wang, P. P., Atabay, K. D., Murphy, E. A., Doan, R. N., Hecht, J. L., & Walsh, C. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3980 · Cited by 288

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15621 · Cited by 282

Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification

Nicolas, G., Pottier, C., Maltête, D., Coutant, S., Rovelet-Lecrux, A., Legallic, S., Rousseau, S., Vaschalde, Y., Guyant-Maréchal, L., Augustin, J., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31827ccf34 · Cited by 279

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model

Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G., & Michikawa, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225532 · Cited by 275

Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells

Kim, K., Lee, H. W., Lee, H., Kim, S. C., Seo, Y. J., Chung, W., Eum, H. H., Nam, D., Kim, J., Joo, K. M., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0692-3 · Cited by 269

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

Li, F., Lan, Y., Wang, Y., Wang, J., Yang, G., Meng, F., Han, H., Meng, A., Wang, Y., & Yang, X. Y. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.011 · Cited by 268

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer.

Zhang, L., Yang, N., Park, J.-W., Katsaros, D., Fracchioli, S., Cao, G., O’Brien-Jenkins, A., Randall, T. C., Rubin, S. C., & Coukos, G. (2003) · PubMed · Cited by 263

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain

Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07002.x · Cited by 261

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells

Nakagomi, T., Kubo, S., Nakano‐Doi, A., Sakuma, R., Lu, S., Narita, A., Kawahara, M., Taguchi, A., & Matsuyama, T. (2015) · Stem Cells · doi:10.1002/stem.1977 · Cited by 260

CNS pericytes: Concepts, misconceptions, and a way out

Krueger, M. W., & Bechmann, I. (2009) · Glia · doi:10.1002/glia.20898 · Cited by 257

Blood–spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice

Winkler, E. A., Sengillo, J. D., Sagare, A. P., Zhao, Z., Ma, Q., Zuniga, E., Wang, Y., Zhong, Z., Sullivan, J. S., Griffin, J. H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401595111 · Cited by 238

Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic Stroke

SLEVIN, M. A., Krupiński, J., Słowik, A., Kumar, P., Szczudlik, A., & Gaffney, J. J. (2000) · Stroke · doi:10.1161/01.str.31.8.1863 · Cited by 233

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide

Kováč, A., Erickson, M. A., & Banks, W. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-139 · Cited by 233

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

Winkler, E. A., Sengillo, J. D., Bell, R. D., Wang, J., & Zlokovic, B. V. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.113 · Cited by 226

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells

Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215621 · Cited by 226

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

Guemez-Gamboa, A., Nguyen, L. N., Yang, H., Zaki, M. S., Kara, M., Ben-Omran, T., Akizu, N., Rosti, R. O., Rosti, B., Scott, E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3311 · Cited by 225

Integrin α4β1–VCAM-1–mediated adhesion between endothelial and mural cells is required for blood vessel maturation

Garmy-Susini, B. H., Jin, H., Zhu, Y., Sung, R.-J., Hwang, R. F., & Varner, J. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23445 · Cited by 216

TGFβ is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells

Darland, D. C., & D'Amore, P. A. (2001) · Angiogenesis · doi:10.1023/a:1016611824696 · Cited by 211

Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells

Jin, S., Hansson, E. M., Tikka, S., Lanner, F., Sahlgren, C., Farnebo, F. A., Baumann, M., Kalimo, H., & Lendahl, U. (2008) · Circulation Research · doi:10.1161/circresaha.107.167965 · Cited by 202

PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development

Olson, L. E., & Soriano, P. M. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.04.019 · Cited by 199

Neurodegeneration and the neurovascular unit

Zloković, B. V. (2010) · Nature Medicine · doi:10.1038/nm1210-1370 · Cited by 193

Microarray analysis of blood microvessels from PDGF‐B and PDGF‐Rβ mutant mice identifies novel markers for brain pericytes

Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P., Betsholtz, C., Bondjers, C., He, L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4944fje · Cited by 193

Wnt signaling in the vasculature

Reis, M., & Liebner, S. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.12.023 · Cited by 192

Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development

Tallquist, M. D., French, W. J., & Soriano, P. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000052 · Cited by 192

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

Hultman, K., Strickland, S., & Norris, E. H. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.76 · Cited by 183

Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage

Benest, A. V., Kruse, K., Savant, S., Thomas, M., Laib, A. M., Loos, E. K., Fiedler, U., & Augustin, H. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070459 · Cited by 178

Gap Junction Communication Mediates Transforming Growth Factor-β Activation and Endothelial-Induced Mural Cell Differentiation

Hirschi, K. K., Burt, J. M., Hirschi, K. D., & Dai, C. (2003) · Circulation Research · doi:10.1161/01.res.0000091259.84556.d5 · Cited by 176

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Ghosh, M., Balbi, M., Hellal, F., Dichgans, M., Lindauer, U., & Plesnila, N. (2015) · Annals of Neurology · doi:10.1002/ana.24512 · Cited by 174

Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier

Reyahi, A., Nik, A. M., Ghiami, M., Gritli-Linde, A., Pontén, F., Johansson, B. R., & Carlsson, P. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.05.008 · Cited by 174

A role for human brain pericytes in neuroinflammation

Jansson, D., Rustenhoven, J., Feng, S. X., Hurley, D., Oldfield, R. L., Bergin, P., Mee, E. W., Faull, R. L. M., & Dragunow, M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-104 · Cited by 174

Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells

Christian, S., Winkler, R., Helfrich, I., Boos, A. M., Besemfelder, E., Schadendorf, D., & Augustin, H. G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070623 · Cited by 169

Cell‐specific blood–brain barrier regulation in health and disease: a focus on hypoxia

Engelhardt, S., Patkar, S., & Ogunshola, O. O. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12489 · Cited by 168

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization

Dieterich, L. C., Mellberg, S., Langenkamp, E., Zhang, L., Zieba, A., Salomäki, H., Teichert, M., Huang, H., Edqvist, P.-H. D., Kraus, T. F. J., et al. (2012) · The Journal of Pathology · doi:10.1002/path.4072 · Cited by 167

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

Alata, W., Ye, Y., St‐Amour, I., Vandal, M., & Calon, F. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.172 · Cited by 164

Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.

Shaheen, R. M., Tseng, W. W., Davis, D. W., Liu, W., Reinmuth, N., Vellagas, R., Wieczorek, A. A., Ogura, Y., McConkey, D. J., Drazan, K. E., et al. (2001) · PubMed · Cited by 162

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

Reitz, C. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.346 · Cited by 162

EphB4 controls blood vascular morphogenesis during postnatal angiogenesis

Erber, R., Eichelsbacher, U., Powajbo, V., Korn, T., Djonov, V., Lin, J., Hammes, H., Grobholz, R., Ullrich, A., & Vajkoczy, P. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600949 · Cited by 158

The complex mural cell: Pericyte function in health and disease

Dijk, C. V., Nieuweboer, F. E., Pei, J. Y., Xu, Y. J., Bürgisser, P. E., van Mulligen, E., el Azzouzi, H., Duncker, D. J., Verhaar, M. C., & Cheng, C. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.258 · Cited by 156

The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy

Baloyannis, S. J., & Baloyannis, I. S. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.010 · Cited by 150

Maintaining blood–brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation

Al-Ahmad, A. J., Gassmann, M., & Ogunshola, O. O. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21638 · Cited by 147

Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System

Henshall, T. L., Keller, A., He, L., Johansson, B. R., Wallgard, E., Raschperger, E., Mäe, M. A., Jin, S., Betsholtz, C., & Lendahl, U. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.304849 · Cited by 145

Differentiation of the brain vasculature: the answer came blowing by the Wnt

Liebner, S., & Plate, K. H. (2010) · Vascular Cell · doi:10.1186/2040-2384-2-1 · Cited by 145

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

Alakbarzade, V., Hameed, A., Quek, D. Q. Y., Chioza, B. A., Baple, E. L., Cazenave-Gassiot, A., Nguyen, L. N., Wenk, M. R., Ahmad, A. Q., Sreekantan-Nair, A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3313 · Cited by 144

Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier

Shimizu, F., Sano, Y., Saito, K., Abe, M., Maeda, T., Haruki, H., & Kanda, T. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0626-8 · Cited by 144

Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes

Sagare, A. P., Sweeney, M. D., Makshanoff, J., & Zlokovic, B. V. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.09.025 · Cited by 142

Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature

Yamanishi, S., Katsumura, K., Kobayashi, T., & Puro, D. G. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01012.2005 · Cited by 142

Venular Basement Membranes Ubiquitously Express Matrix Protein Low-Expression Regions

Voisin, M.-B., Pröbstl, D., & Nourshargh, S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090510 · Cited by 141

Cholinergic modulation of the cortical microvascular bed

Hamel, É. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)45012-7 · Cited by 140

FOXO1 Plays an Important Role in Enhanced Microvascular Cell Apoptosis and Microvascular Cell Loss in Type 1 and Type 2 Diabetic Rats

Behl, Y., Krothapalli, P., Desta, T., Roy, S., & Graves, D. T. (2009) · Diabetes · doi:10.2337/db08-0537 · Cited by 138

Early Pericyte Response to Brain Hypoxia in Cats: An Ultrastructural Study

Gönül, E., Düz, B., Kahraman, S., Kayali, H., Kubar, A., & Timurkaynak, E. (2002) · Microvascular Research · doi:10.1006/mvre.2002.2413 · Cited by 137

Evaluation of a Previously Suggested Plasma Biomarker Panel to Identify Alzheimer's Disease

Björkqvist, M., Ohlsson, M., Minthon, L., & Hansson, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029868 · Cited by 135

Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro

Pieper, C., Marek, J. J., Unterberg, M., Schwerdtle, T., & Galla, H. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.004 · Cited by 132

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

Park, L., Zhou, J., Zhou, P., Pistick, R., Jamal, S. E., Younkin, L. H., Pierce, J. P., Arreguin, A. J., Anrather, J., Younkin, S. G., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300021110 · Cited by 132

Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier

Zloković, B. V. (1995) · Pharmaceutical Research · doi:10.1023/a:1016254514167 · Cited by 131

Notch1 Stimulation Induces a Vascularization Switch With Pericyte-Like Cell Differentiation of Glioblastoma Stem Cells

Guichet, P., Guelfi, S., Teigell, M., Hoppe, L., Bakalara, N., Bauchet, L., Duffau, H., Lamszus, K., Rothhut, B., & Hugnot, J. (2014) · Stem Cells · doi:10.1002/stem.1767 · Cited by 129

A Computational Model Predicting Disruption of Blood Vessel Development

Kleinstreuer, N., Dix, D. J., Rountree, M. R., Baker, N., Sipes, N. S., Reif, D. M., Spencer, R. M., & Knudsen, T. B. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002996 · Cited by 123

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.76 · Cited by 122

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown

Halliday, M. R., Pomara, N., Sagare, A. P., Mack, W. J., Frangione, B., & Zlokovic, B. V. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3841 · Cited by 119

Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

Zloković, B. V., Lipovac, M. N., Begley, D. J., Davson, H., & Rakić, L. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb03431.x · Cited by 118

Tumour necrosis factor α-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members

Hermey, G., Sjøgaard, S. S., Petersen, C. M., Nykjær, A., & Gliemann, J. (2006) · Biochemical Journal · doi:10.1042/bj20051364 · Cited by 116

Adenosine activates ATP-sensitive K+ currents in pericytes of rat retinal microvessels: role of A1 and A2a receptors

Li, Q., & Puro, D. G. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02607-5 · Cited by 116

Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma

Simonavicius, N., Robertson, D. M., Bax, D. A., Jones, C., Huijbers, I. J., & Isacke, C. M. (2008) · Modern Pathology · doi:10.1038/modpathol.3801006 · Cited by 115

Blood-brain barrier permeability to leucine-enkephalin,d-Alanine2-d-leucine5-enkephalin and their N-terminal amino acid (tyrosine)

Zlokovic, B. V., Begley, D. J., & Chain-Eliash, D. G. (1985) · Brain Research · doi:10.1016/0006-8993(85)90423-8 · Cited by 114

Presenilins Mediate Phosphatidylinositol 3-Kinase/AKT and ERK Activation via Select Signaling Receptors

Kang, D. E., Yoon, I., Repetto, E., Busse, T., Yermian, N., Ie, L., & Koo, E. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500833200 · Cited by 107

Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpression

Feng, Y., Hagen, F. V., Pfister, F., Djokic, S., Hoffmann, S., de Back, W., Wagner, P., Lin, J., Deutsch, U., & Hammes, H. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-05-0277 · Cited by 107

EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures

Salvucci, O., Maric, D., Economopoulou, M., Sakakibara, S., Merlin, S., Follenzi, A., & Tosato, G. (2009) · Blood · doi:10.1182/blood-2008-12-192294 · Cited by 107

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain

Arnold, T. D., Niaudet, C., Pang, M.-F., Siegenthaler, J. A., Gaengel, K., Jung, B., Ferrero, G., Mukouyama, Y., Fuxe, J., Akhurst, R. J., et al. (2014) · Development · doi:10.1242/dev.107193 · Cited by 104

N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis

Tillet, E., Vittet, D., Féraud, O., Moore, R. H., Kemler, R., & Huber, P. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.021 · Cited by 99

Neurovascular relationships in hippocampal slices: physiological and anatomical studies of mechanisms underlying flow-metabolism coupling in intraparenchymal microvessels

Lovick, T. A., Brown, L. A., & Key, B. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00737-4 · Cited by 99

Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development

MacFadyen, J. R., Savage, K., Wienke, D., & Isacke, C. M. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2006.07.006 · Cited by 97

Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone

Zloković, B. V., Segal, M. B., Begley, D. J., Davson, H., & Rakić, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90963-1 · Cited by 92

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

Gama Sosa, M. A., Gasperi, R. D., Rocher, A. B., Wang, A. C.-J., Janssen, W. G. M., Flores, T., Perez, G. M., Schmeidler, J., Dickstein, D. L., Hof, P. R., et al. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090482 · Cited by 92

Cerebrovascular Remodeling and Epilepsy

Marchi, N., & Lerner‐Natoli, M. (2012) · The Neuroscientist · doi:10.1177/1073858412462747 · Cited by 92

Neurovascular unit on a chip: implications for translational applications

Alcendor, D. J., Block, F. E., Cliffel, D. E., Daniels, J. S., Ellacott, K. L. J., Goodwin, C. R., Hofmeister, L. H., Li, D., Markov, D. A., May, J. C., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt379 · Cited by 90

Differential TGF-β Signaling in Retinal Vascular Cells: A Role in Diabetic Retinopathy?

van Geest, R. J., Klaassen, I., Vogels, I. M. C., Noorden, C. J. F. V., & Schlingemann, R. O. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4181 · Cited by 87

Effect of Prenatal Glucocorticoids on Cerebral Vasculature of the Developing Brain

Vinukonda, G., Dummula, K., Malik, S., Hu, F.-R., Thompson, C. I., Csiszar, A., Ungvari, Z., & Ballabh, P. (2010) · Stroke · doi:10.1161/strokeaha.110.588400 · Cited by 85

Update and Mutational Analysis ofSLC20A2: A Major Cause of Primary Familial Brain Calcification

de Lemos, R. R., Ramos, E. M., Legati, A., Nicolas, G., Jenkinson, E. M., Livingston, J. H., Crow, Y. J., Campion, D., Coppola, G., & de Oliveira, J. R. M. (2015) · Human Mutation · doi:10.1002/humu.22778 · Cited by 80

Cerebral Cavernous Malformation-1 Protein Controls DLL4-Notch3 Signaling Between the Endothelium and Pericytes

Schulz, G. B., Wieland, E., Wüstehube‐Lausch, J., Boulday, G., Moll, I., Tournier‐Lasserve, E., & Fischer, A. (2015) · Stroke · doi:10.1161/strokeaha.114.007512 · Cited by 74

Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke

Cui, X., Chopp, M., Zacharek, A., Ye, X., Roberts, C. J., & Chen, J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.005 · Cited by 71

EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis

Augustin, H. G., & Reiss, Y. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0770-9 · Cited by 68

FOXO1 plays an essential role in apoptosis of retinal pericytes.

Alikhani, M., Roy, S., & Graves, D. T. (2010) · PubMed Central · Cited by 63

Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+waves

Mufti, R. E., Brett, S. E., Tran, C. H. T., El-Rahman, R. R. A., Anfinogenova, Y., EL‐Yazbi, A. F., Cole, W. C., Jones, P. P., Chen, S. R. W., & Welsh, D. G. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.193300 · Cited by 61

MR Perfusion–derived Hemodynamic Parametric Response Mapping of Bevacizumab Efficacy in Recurrent Glioblastoma

Kickingereder, P., Radbruch, A., Burth, S., Wick, A., Heiland, S., Schlemmer, H.-P., Wick, W., Bendszus, M., & Bonekamp, D. (2015) · Radiology · doi:10.1148/radiol.2015151172 · Cited by 60

Differential expression of capillary VEGF isoforms following traumatic brain injury

Dore‐Duffy, P., Wang, X., Mehedi, A., Kreipke, C. W., & Rafols, J. A. (2007) · Neurological Research · doi:10.1179/016164107x204729 · Cited by 59

Tat 101-Mediated Enhancement of Brain Pericyte Migration Involves Platelet-Derived Growth Factor Subunit B Homodimer: Implications for Human Immunodeficiency Virus-Associated Neurocognitive Disorders

Niu, F., Yao, H., Zhang, W., Sutliff, R. L., & Buch, S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1139-14.2014 · Cited by 58

Calcium influx pathways in rat CNS pericytes

Kamouchi, M., Kitazono, T., Ago, T., Wakisaka, M., Ooboshi, H., Ibayashi, S., & Iida, M. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.03.008 · Cited by 58

The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand

GLIEMANN, J., HERMEY, G., NYKJÆR, A., PETERSEN, C. M., JACOBSEN, C., & ANDREASEN, P. A. (2004) · Biochemical Journal · doi:10.1042/bj20040149 · Cited by 58

Nitric Oxide/cGMP-Induced Inhibition of Calcium and Chloride Currents in Retinal Pericytes

Sakagami, K., Kawamura, H., Wu, D. M., & Puro, D. G. (2001) · Microvascular Research · doi:10.1006/mvre.2001.2343 · Cited by 57

Endogenous Brain Pericytes Are Widely Activated and Contribute to Mouse Glioma Microvasculature

Svensson, A., Özen, Í., Genové, G., Paul, G., & Bengzon, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123553 · Cited by 53

Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament

Dai, M., Nuttall, A. L., Yang, Y., & Shi, X. (2009) · Hearing Research · doi:10.1016/j.heares.2009.04.018 · Cited by 53

Blood-brain barrier modeling: challenges and perspectives

Ruck, T., Bittner, S., & Meuth, S. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.158342 · Cited by 52

Dopamine activates ATP-sensitive K+ currents in rat retinal pericytes

Wu, D. M., Kawamura, H., Li, Q., & Puro, D. G. (2001) · Visual Neuroscience · doi:10.1017/s0952523801186104 · Cited by 49

CytoSolve: A Scalable Computational Method for Dynamic Integration of Multiple Molecular Pathway Models

Ayyadurai, V. A. S., & Dewey, C. F. (2010) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-010-0143-x · Cited by 43

Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)

Li, X., Ji, W., Zhang, R., Folta‐Stogniew, E. J., Wang, M., & Boggon, T. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.211250 · Cited by 37

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

Wang, F., Remke, M., Bhat, K., Wong, E. T., Zhou, S. Y., Ramaswamy, V., Dubuc, A. M., Fonkem, E., Salem, S., Zhang, H., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2779 · Cited by 29

Membrane potentials in retinal capillary pericytes: excitability and effect of vasoactive substances.

Helbig, H., Kornacker, S., Berweck, S., Stahl, F., Lepple-Wienhues, A., & Wiederholt, M. (1992) · PubMed · Cited by 27

Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes

Nakamura, K., Kamouchi, M., Kitazono, T., Kuroda, J., Shono, Y., Hagiwara, N., Ago, T., Ooboshi, H., Ibayashi, S., & Iida, M. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.12.001 · Cited by 22

Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation

Jurek, A., Heldin, C., & Lennartsson, J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.09.013 · Cited by 20

Spatial correlations between beta-amyloid (Abeta) deposits and blood vessels in familial Alzheimer's disease.

Armstrong, R. A. (2008) · PubMed · Cited by 19

Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons

Takahashi, H., Takata, F., Matsumoto, J., Machida, T., Yamauchi, A., Dohgu, S., & Kataoka, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.016 · Cited by 15

The Role of Intracellular Trafficking and the Vps10D Receptors In Alzheimer‘s Disease

Reitz, C. (2012) · Future Neurology · doi:10.2217/fnl.12.31 · Cited by 15

Untitled work

(2000) · doi:10.1002/1097-0177(200007)218:3

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312

Molecular diversity and specializations among the cells of the adult mouse brain

Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,531

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243

The role of brain vasculature in neurodegenerative disorders

Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0234-x · Cited by 998

The Complex and Integral Roles of Pericytes Within the Neurovascular Unit in Health and Disease

Sutherland, B. A. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-62129-2_2 · Cited by 2

Emerging Roles of Pericytes in the Regulation of the Neurovascular Unit in Health and Disease

Hill, J. D., Rom, S., Ramirez, S. H., & Persidsky, Y. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9557-x · Cited by 136

Microvascular pericytes in brain-associated vascular disease

Liu, Q., Yang, Y., & Fan, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109633 · Cited by 45

What Are the Roles of Pericytes in the Neurovascular Unit and Its Disorders?

Benarroch, E. E. (2023) · Neurology · doi:10.1212/wnl.0000000000207379 · Cited by 55

[Pericytes of the Nervous System: Physiological and Pathological Role].

Shimizu, F., & Kanda, T. (2020) · PubMed · doi:10.11477/mf.1416201495 · Cited by 4