Cited by 580Neural and Behavioral Psychology StudiesDecision-Making and Behavioral EconomicsNeurotransmitter Receptor Influence on Behavior

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Separate neural pathways process different decision costs

Rudebeck, Peter H, Walton, Mark E, Smyth, Angharad N, Bannerman, David M, Rushworth, Matthew F S·2006·Nature Neuroscience

DOI 10.1038/nn1756

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Abstract

Behavioral ecologists and economists emphasize that potential costs, as well as rewards, influence decision making. Although neuroscientists assume that frontal areas are central to decision making, the evidence is contradictory and the critical region remains unclear. Here it is shown that frontal lobe contributions to cost-benefit decision making can be understood by positing the existence of two independent systems that make decisions about delay and effort costs. Anterior cingulate cortex lesions affected how much effort rats decided to invest for rewards. Orbitofrontal cortical lesions affected how long rats decided to wait for rewards. The pattern of disruption suggested the deficit could be related to impaired associative learning. Impairments of the two systems may underlie apathetic and impulsive choice patterns in neurological and psychiatric illnesses. Although the existence of two systems is not predicted by economic accounts of decision making, our results suggest that delay and effort may exert distinct influences on decision making.

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Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
Frontal-subcortical circuits and human behavior
Cummings, J. L. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540080076020 · Cited by 2,262
Varieties of impulsivity
Evenden, J. L. (1999) · Psychopharmacology · doi:10.1007/pl00005481 · Cited by 2,044
Advances in Neural Information Processing Systems 18
Murray, I., Mackay, D., Zoubin Ghahramani, A., & Skilling, J. (2006) · Cited by 1,927
Behavioral Theories and the Neurophysiology of Reward
Schultz, W. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070229 · Cited by 1,637
A Quantitative Analysis
Pochet, P. (2006) · Griffith Research Online · Cited by 1,550
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227
Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence
Critchley, H. D., Mathias, C. J., Josephs, O., O’Doherty, J., Zanini, S., Dewar, B., Cipolotti, L., Shallice, T., & Dolan, R. J. (2003) · Brain · doi:10.1093/brain/awg216 · Cited by 1,201
The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold
Brog, J. S., Salyapongse, A., Deutch, A. Y., & Zahm, D. S. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903380209 · Cited by 1,102
Action sets and decisions in the medial frontal cortex
RUSHWORTH, M., WALTON, M., KENNERLEY, S., & BANNERMAN, D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.009 · Cited by 1,004
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Li, F., Li, M., Cao, W., Xu, Y., Luo, Y., Zhong, X., Zhang, J., Dai, R., Zhou, X., Li, Z., et al. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.05.015 · Cited by 34
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Cai, X., & Padoa‐Schioppa, C. (2021) · eLife · doi:10.7554/elife.71695 · Cited by 19
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Authors: Rudebeck, P. H., Walton, M. E., Smyth, A. N., Bannerman, D. M., & Rushworth, M. F. S.
Affiliations: University of Oxford (GB)
Corresponding author: Rudebeck, Peter H
ORCID: Rudebeck, Peter H
Walton, Mark E
Bannerman, David M
Rushworth, Matthew F S
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-08-20
Volume: 9
Issue: 9
Pages: 1161-1168
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1756
OpenAlex: W2136906168
Cited by: 580
References: 52
Citations by year: 2026: 8 · 2025: 15 · 2024: 20 · 2023: 24 · 2022: 26 · 2021: 30 · 2020: 16 · 2019: 32 · 2018: 37 · 2017: 35 · 2016: 37 · 2015: 37 · 2014: 31 · 2013: 40 · 2012: 27
FWCI: 13.76
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders: Wellcome Trust (087736)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: cost-benefit decision making, delay cost, effort cost, anterior cingulate cortex, orbitofrontal cortex, frontal lobe lesions, rats, associative learning, impulsive choice, apathy
MeSH terms: Animals, Behavior, Animal, Choice Behavior, Frontal Lobe, Learning Disabilities, Male, Motor Activity, Neural Pathways, Reaction Time, Reward, Maze Learning, Rats

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Separate neural pathways process different decision costs

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