Cited by 875Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus

Kee, Nohjin, Teixeira, Cátia M, Wang, Afra H, Frankland, Paul W·2007·Nature Neuroscience

DOI 10.1038/nn1847

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Abstract

Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells become functionally integrated into memory networks is not known. We used immunohistochemical approaches to visualize the recruitment of new neurons into circuits supporting water maze memory in intact mice. We show that as new granule cells mature, they are increasingly likely to be incorporated into circuits supporting spatial memory. By the time the cells are 4 or more weeks of age, they are more likely than existing granule cells to be recruited into circuits supporting spatial memory. This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus.

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Authors: Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W.
Affiliations: Hospital for Sick Children (CA)
Universidade do Porto (PT)
University of Toronto (CA)
Corresponding author: Frankland, Paul W
ORCID: Kee, Nohjin
Teixeira, Cátia M
Frankland, Paul W
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-02-04
Volume: 10
Issue: 3
Pages: 355-362
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1847
OpenAlex: W2160071886
Cited by: 875
References: 50
Citations by year: 2026: 8 · 2025: 24 · 2024: 19 · 2023: 16 · 2022: 17 · 2021: 35 · 2020: 39 · 2019: 35 · 2018: 48 · 2017: 41 · 2016: 46 · 2015: 56 · 2014: 56 · 2013: 58 · 2012: 69
FWCI: 21.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: adult neurogenesis, dentate gyrus, granule cells, spatial memory, hippocampus, water maze, neuronal maturation, new neurons
MeSH terms: Age Factors, Animals, Behavior, Animal, Bromodeoxyuridine, Cell Count, Immunohistochemistry, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Phosphopyruvate Hydratase, Space Perception, Time Factors, Oncogene Proteins v-fos, Calcium-Calmodulin-Dependent Protein Kinases, Maze Learning, Dentate Gyrus, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus

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