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Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Abstract
Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells become functionally integrated into memory networks is not known. We used immunohistochemical approaches to visualize the recruitment of new neurons into circuits supporting water maze memory in intact mice. We show that as new granule cells mature, they are increasingly likely to be incorporated into circuits supporting spatial memory. By the time the cells are 4 or more weeks of age, they are more likely than existing granule cells to be recruited into circuits supporting spatial memory. This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus.
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“Consequently, such alterations promote an increased participation of these cells during learning and memory tasks35 and a reconfiguration of DG-CA3 circuits that degrade stored memories.36”
From Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression (2017) · cites this paper as [35]
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Metadata
- Authors
- Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W.
- Affiliations
- Hospital for Sick Children (CA)
- Universidade do Porto (PT)
- University of Toronto (CA)
- Corresponding author
- Frankland, Paul W
- Venue
- Nature Neuroscience
- Published
- 2007-02-04
- Volume
- 10
- Issue
- 3
- Pages
- 355-362
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2160071886
- Cited by
- 875
- References
- 50
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 19 · 2023: 16 · 2022: 17 · 2021: 35 · 2020: 39 · 2019: 35 · 2018: 48 · 2017: 41 · 2016: 46 · 2015: 56 · 2014: 56 · 2013: 58 · 2012: 69
- FWCI
- 21.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, dentate gyrus, granule cells, spatial memory, hippocampus, water maze, neuronal maturation, new neurons
- MeSH terms
- Age Factors, Animals, Behavior, Animal, Bromodeoxyuridine, Cell Count, Immunohistochemistry, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Phosphopyruvate Hydratase, Space Perception, Time Factors, Oncogene Proteins v-fos, Calcium-Calmodulin-Dependent Protein Kinases, Maze Learning, Dentate Gyrus, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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