Running reduces stress and enhances cell genesis in aged mice
Open accessAbstract
Cell proliferation and neurogenesis are diminished in the aging mouse dentate gyrus. However, it is not known whether isolated or social living affects cell genesis and stress levels in old animals. To address this question, aged (17-18 months old) female C57Bl/6 mice were single or group housed, under sedentary or running conditions. We demonstrate that both individual and socially housed aged C57Bl/6 mice have comparable basal cell proliferation levels and demonstrate increased running-induced cell genesis. To assess stress levels in young and aged mice, corticosterone (CORT) was measured at the onset of the active/dark cycle and 4h later. In young mice, no differences in CORT levels were observed as a result of physical activity or housing conditions. However, a significant increase in stress in socially housed, aged sedentary animals was observed at the onset of the dark cycle; CORT returned to basal levels 4h later. Together, these results indicate that voluntary exercise reduces stress in group housed aged animals and enhances hippocampal cell proliferation.
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Physical exercise rescues the decrease of neurogenesis induced by stress in adult as well as in old mice.
“Concerning the effects of running, several reports indicate that physical exercise also rescues the decrease of neurogenesis induced by stress in adult as well as in old mice (Kannangara et al., 2011).”
From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Kannangara et al., 2011
The Results and Discussion (pages unavailable) report that running increased hippocampal cell proliferation in aged mice and note earlier findings of increased cell genesis in young mice. But the Discussion explicitly says the 11-day study cannot establish a change in neurogenesis. Although running lowered a stress marker in socially housed aged mice, the paper does not show that it rescued a stress-induced decrease in neurogenesis in either age group. (LLM, conf=0.88)
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- Authors
- Kannangara, T. S., Lucero, M. J., Gil-Mohapel, J., Drapala, R. J., Simpson, J. M., Christie, B. R., & van Praag, H.
- Affiliations
- University of Victoria (CA)
- Salk Institute for Biological Studies (US)
- University of British Columbia (CA)
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 32
- Issue
- 12
- Pages
- 2279-2286
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC6016367
- OpenAlex
- W2154842075
- Cited by
- 107
- References
- 40
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 11 · 2013: 7 · 2012: 11
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- voluntary running, physical activity, aging, stress, corticosterone, hippocampal neurogenesis, dentate gyrus, cell proliferation, social housing, single housing, sedentary behavior, C57BL/6 mice
- MeSH terms
- Animals, Corticosterone, Female, Mice, Inbred C57BL, Motor Activity, Running, Social Isolation, Stress, Psychological, Up-Regulation, Dentate Gyrus, Cell Proliferation, Mice, Neurogenesis
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