The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone
Abstract
Three subtypes of vesicular transporters accumulate glutamate into synaptic vesicles to promote its vesicular release. One of the subtypes, VGLUT3, is expressed in neurons, including cholinergic striatal interneurons, that are known to release other classical transmitters. Here we showed that disruption of the Slc17a8 gene (also known as Vglut3) caused an unexpected hypocholinergic striatal phenotype. Vglut3(-/-) mice were more responsive to cocaine and less prone to haloperidol-induced catalepsy than wild-type littermates, and acetylcholine release was decreased in striatum slices lacking VGLUT3. These phenotypes were associated with a colocalization of VGLUT3 and the vesicular acetylcholine transporter (VAChT) in striatal synaptic vesicles and the loss of a synergistic effect of glutamate on vesicular acetylcholine uptake. We propose that this vesicular synergy between two transmitters is the result of the unbalanced bioenergetics of VAChT, which requires anion co-entry for continuing vesicular filling. Our study reveals a previously unknown effect of glutamate on cholinergic synapses with potential functional and pharmacological implications.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These complementary dependencies may explain the observed synergies between vGluT and VAChT or vGluT and the vesicular zinc transporter (ZnT3) when these are localized to the same synaptic vesicle.5,21,22”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [22]
In the citing paper
“However, many of these neurons also contain the vesicular glutamate transporters (vGluT1/2/3) that are coexpressed with molecular machinery for Ach synthesis, vesicular packaging, and release in multiple brain regions, including the striatum, basal forebrain, and medial habenula (mHb).22,56,57”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [22]
In the citing paper
“Immunogold EM and immunoprecipitation experiments suggest that vGluT and VAChT co-package glutamate and ACh into the same synaptic vesicle in both mHb to IPN synapses and striatal cholinergic to medium spiny neuron synapses 21,22,56 (Figure 1A).”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [22]
In the citing paper
“Interestingly, several groups have found that vGluT and VAChT function synergistically and that depletion of one transporter or neurotransmitter also depletes loading and release of the other.21,22,63,69”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [22]
In the citing paper
“Several groups have found evidence for Ach and glutamate being copackaged into the same synaptic vesicles at this synapse 21,22,56,124”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [22]
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
The Basal Ganglia and Adaptive Motor Control
Graybiel, A. M., Aosaki, T., Flaherty, A. W., & Kimura, M. (1994) · Science · doi:10.1126/science.8091209 · Cited by 1,324
Huttner, W. Β., SCHIEBLER, W., Greengard, P., & Camilli, P. V. D. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.5.1374 · Cited by 1,172
Rogers, D. C., Fisher, E. M. C., Brown, S. D. M., Peters, J., Hunter, A. J., & Martin, J. E. (1997) · Mammalian Genome · doi:10.1007/s003359900551 · Cited by 795
Crawley, J. N. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01258-x · Cited by 772
VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate
Fremeau, R. T., Voglmaier, S., Seal, R. P., & Edwards, R. H. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.005 · Cited by 745
A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons
Gras, C., Herzog, E., Bellenchi, G. C., Bernard, V., Ravassard, P., Pohl, M., Gasnier, B., Giros, B., & El Mestikawy, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05442.2002 · Cited by 639
Self-citationHerzog, É., Bellenchi, G. C., Gras, C., Bernard, V., Ravassard, P., Bedet, C., Gasnier, B., Bruno Giros, A., & Mestikawy, S. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-j0001.2001 · Cited by 625
Self-citationFremeau, R. T., Burman, J. L., Qureshi, T., Tran, C. H., Proctor, J. M., Johnson, J., Zhang, H., Sulzer, D. L., Copenhagen, D. R., Storm‐Mathisen, J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222546799 · Cited by 568
Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein
Fleming, S. M., Salcedo, J. D., Fernagut, P., Rockenstein, E. M., Masliah, E., Levine, M. S., & Chesselet, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3080-04.2004 · Cited by 477
Cited by
Sorted by citations
Wang, H., & Morales, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06576.x · Cited by 478
Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors
Seal, R. P., Wang, X., Guan, Y., Raja, S. N., Woodbury, C. J., Basbaum, A. I., & Edwards, R. H. (2009) · Nature · doi:10.1038/nature08505 · Cited by 465
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo
Hnasko, T. S., Chuhma, N., Zhang, H., Goh, G. Y., Sulzer, D., Palmiter, R. D., Rayport, S., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.012 · Cited by 405
Metabolic Control of Vesicular Glutamate Transport and Release
Juge, N., Gray, J. A., Omote, H., Miyaji, T., Inoue, T., Hara, C., Uneyama, H., Edwards, R. H., Nicoll, R. A., & Moriyama, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.002 · Cited by 401
From glutamate co-release to vesicular synergy: vesicular glutamate transporters
El Mestikawy, S., Wallén-Mackenzie, Å., Fortin, G. M., Descarries, L., & Trudeau, L.-E. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2969 · Cited by 385
Overview of glutamatergic neurotransmission in the nervous system
Niciu, M. J., Kelmendi, B., & Sanacora, G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.08.008 · Cited by 363
Ruel, J., Emery, S. B., Nouvian, R., Bersot, T., Amilhon, B., Rybroek, J. M. V., Rebillard, G., Lenoir, M., Eybalin, M., Delprat, B., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.07.008 · Cited by 323
Self-citationNeurotransmitter Corelease: Mechanism and Physiological Role
Hnasko, T. S., & Edwards, R. H. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153315 · Cited by 284
Striatal cholinergic interneuron regulation and circuit effects
Lim, S. A. O., Kang, U. J., & McGehee, D. S. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00022 · Cited by 244
Dual-transmitter neurons: functional implications of co-release and co-transmission
Vaaga, C. E., Borisovska, M., & Westbrook, G. L. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.04.010 · Cited by 221
Corelease of acetylcholine and GABA from cholinergic forebrain neurons
Saunders, A., Granger, A. J., & Sabatini, B. L. (2015) · eLife · doi:10.7554/elife.06412 · Cited by 200
Amilhon, B., Lepicard, È., Renoir, T., Mongeau, R., Popa, D., Poirel, O., Miot, S., Gras, C., Gardier, A. M., Gallego, J., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5196-09.2010 · Cited by 186
Self-citationCholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum
Higley, M. J., Gittis, A. H., Oldenburg, I. A., Balthasar, N., Seal, R. P., Edwards, R. H., Lowell, B. B., Kreitzer, A. C., & Sabatini, B. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019155 · Cited by 175
“the vesicular glutamate transporter VGluT3, which co-localizes with the vesicular ACh transporter in the same presynaptic terminals [6,7,9].”
BackgroundInfluentialGlutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map
Noh, J., Seal, R. P., Garver, J. A., Edwards, R. H., & Kandler, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2478 · Cited by 175
Vesicular and Plasma Membrane Transporters for Neurotransmitters
Blakely, R. D., & Edwards, R. H. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005595 · Cited by 169
Gonzales, K. K., & Smith, Y. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12762 · Cited by 175
Synaptic and Vesicular Coexistence of VGLUT and VGAT in Selected Excitatory and Inhibitory Synapses
Zander, J.-F., Münster‐Wandowski, A., Brunk, I., Pahner, I., Gómez‐Lira, G., Heinemann, U., Gutiérrez, R., Laube, G., & Ahnert‐Hilger, G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0141-10.2010 · Cited by 154
The primitive brain of early Homo
Ponce de León, M. S., Bienvenu, T., Marom, A., Engel, S., Tafforeau, P., Alatorre Warren, J. L., Lordkipanidze, D., Kurniawan, I., Murti, D. B., Suriyanto, R. A., et al. (2021) · Science · doi:10.1126/science.aaz0032 · Cited by 142
The multilingual nature of dopamine neurons
Trudeau, L., Hnasko, T. S., Wallén‐Mackenzie, Å., Morales, M., Rayport, S., & Sulzer, D. L. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63425-2.00006-4 · Cited by 138
Cholinergic circuits in cognitive flexibility
Prado, V. F., Janíčková, H., Al‐Onaizi, M., & Prado, M. A. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.013 · Cited by 158
Weston, M. C., Nehring, R. B., Wojcik, S. M., & Rosenmund, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.002 · Cited by 134
Regulation of cholinergic activity by the vesicular acetylcholine transporter
Prado, V. F., Roy, A., Kolisnyk, B., Gros, R., & Prado, M. A. M. (2013) · Biochemical Journal · doi:10.1042/bj20121662 · Cited by 137
Distribution of vesicular glutamate transporters in the human brain
Vigneault, É., Poirel, O., Riad, M., Prud’homme, J., Dumas, S., Turecki, G., Fasano, C., Mechawar, N., & Mestikawy, S. E. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00023 · Cited by 132
Self-citationSego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 132
Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties
Silm, K., Yang, J., Marcott, P. F., Asensio, C. S., Eriksen, J., Guthrie, D. A., Newman, A. H., Ford, C., & Edwards, R. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.031 · Cited by 133
Balschun, D., Moechars, D., Callaerts‐Vegh, Z., Vermaercke, B., Acker, N. V., Andries, L. J., & D’Hooge, R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp133 · Cited by 123
Bergersen, L. H., Morland, C., Ormel, L., Rinholm, J. E., Larsson, M., Wold, J. F. H., Røe, Å. T., Stranna, A., Santello, M., Bouvier, D. S., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr254 · Cited by 122
VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation
Birgner, C., Nordenankar, K., Lundblad, M., Méndez, J. A. T., Smith, C., Grevès, M. L., Galter, D., Olson, L., Fredriksson, A., Trudeau, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910986107 · Cited by 119
New Insights Into Cholinergic Neuron Diversity
Ahmed, N. Y., Knowles, R., & Dehorter, N. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00204 · Cited by 108
Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons
Steinkellner, T., Zell, V., Farino, Z. J., Sonders, M. S., Villeneuve, M., Freyberg, R. J., Przedborski, S., Lu, W., Freyberg, Z., & Hnasko, T. S. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95795 · Cited by 102
Fernandez, S. P., Cauli, B., Cabezas, C., Muzerelle, A., Poncer, J.-C., & Gaspar, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-015-1142-4 · Cited by 100
Striatal cholinergic neurotransmission requires VGLUT3
Nelson, A. B., Bussert, T. G., Kreitzer, A. C., & Seal, R. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0901-14.2014 · Cited by 99
An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence
Frahm, S., Antolin-Fontes, B., Görlich, A., Zander, J.-F., Ahnert-Hilger, G., & Ibañez-Tallon, I. (2015) · eLife · doi:10.7554/elife.11396 · Cited by 98
Multiplexed neurochemical signaling by neurons of the ventral tegmental area
Barker, D. J., Root, D. H., Zhang, S., & Morales, M. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.12.016 · Cited by 105
The dual dopamine‐glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain
Bérubé‐Carrière, N., Riad, M., Bo, G. D., Lévesque, D., Trudeau, L., & Descarries, L. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22194 · Cited by 98
Guzmán, M. S., Jaeger, X. D., Raulic, S., Souza, I. A., Li, A. X., Schmid, S., Menon, R. S., Gainetdinov, R. R., Caron, M. G., Bartha, R., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001194 · Cited by 99
Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking
Collins, A. L., & Saunders, B. T. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24587 · Cited by 93
Glutamatergic drive of the dorsal raphe nucleus
Soiza‐Reilly, M., & Commons, K. G. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.04.004 · Cited by 98
Gagnon, D., & Parent, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087709 · Cited by 95
Alsiö, J., Nordenankar, K., Arvidsson, E., Birgner, C., Mahmoudi, S., Halbout, B., Smith, C., Fortin, G. M., Olson, L., Descarries, L., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2397-11.2011 · Cited by 92
Lack of Evidence for Vesicular Glutamate Transporter Expression in Mouse Astrocytes
Li, D., Hérault, K., Silm, K., Evrard, A., Wojcik, S. M., Oheim, M., Herzog, É., & Ropert, N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3667-12.2013 · Cited by 86
Ni, Y., Feng, J., Liu, J., Yu, H., Wei, H., Du, Y., Liu, L., Sun, L., Zhou, J., & Xu, W. (2021) · Advanced Science · doi:10.1002/advs.202102036 · Cited by 83
Chuhma, N., Choi, W., Mingote, S., & Rayport, S. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.057 · Cited by 85
The role of acetylcholine in negative encoding bias: Too much of a good thing?
Mineur, Y. S., & Picciotto, M. R. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14641 · Cited by 78
Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism
Eriksen, J., Chang, R., McGregor, M., Silm, K., Suzuki, T., & Edwards, R. H. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.026 · Cited by 76
Glutamate Corelease Promotes Growth and Survival of Midbrain Dopamine Neurons
Fortin, G. M., Bourque, M.-J., Méndez, J. A. T., Leo, D., Nordenankar, K., Birgner, C., Arvidsson, E., Rymar, V. V., Bérubé‐Carrière, N., Claveau, A.-M., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1939-12.2012 · Cited by 77
Trudeau, L., & Mestikawy, S. E. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00113 · Cited by 83
Self-citationFasano, C., Bourque, M.-J., Lapointe, G., Leo, D., Thibault, D., Haber, M., Kortleven, C., DesGroseillers, L., Murai, K. K., & Trudeau, L.-É. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.030 · Cited by 67
Aitta‐aho, T., Hay, Y. A., Phillips, B. U., Saksida, L. M., Bussey, T. J., Paulsen, O., & Apergis‐Schoute, J. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.064 · Cited by 79
Fuxé, K., Borroto‐Escuela, D. O., Romero‐Fernandez, W., Dı́az-Cabiale, Z., Rivera, A., Ferraro, L., Tanganelli, S., Tarakanov, A. O., Garriga, P., Narváez, J. Á., et al. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00136 · Cited by 73
Upmanyu, N., Jin, J., Emde, H. V. D., Ganzella, M., Bösche, L., Malviya, V. N., Zhuleku, E., Politi, A. Z., Ninov, M., Silbern, I., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.008 · Cited by 69
Is Aspartate an Excitatory Neurotransmitter?
Herring, B. E., Silm, K., Edwards, R. H., & Nicoll, R. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0524-15.2015 · Cited by 72
Glutamate receptors of the delta family are widely expressed in the adult brain
Hepp, R., Hay, Y. A., Aguado, C., Lujan, R., Dauphinot, L., Potier, M. C., Nomura, S., Poirel, O., El Mestikawy, S., Lambolez, B., et al. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0827-4 · Cited by 71
Self-citationLuchicchi, A., Bloem, B., Viaña, J. N. M., Mansvelder, H. D., & Role, L. W. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00024 · Cited by 74
Tien, N.-W., Kim, T., & Kerschensteiner, D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.025 · Cited by 67
Sakae, D. Y., Marti, F., Lecca, S., Vorspan, F., Martín‐García, E., Morel, L. J., Henrion, A., Cuesta, J., Besnard, A., Heck, N., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.104 · Cited by 68
Self-citationJackson, J., Bland, B. H., & Antle, M. C. (2008) · Synapse · doi:10.1002/syn.20581 · Cited by 66
Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?
Liefferinge, J. V., Massie, A., Portelli, J., Giovanni, G. D., & Smolders, I. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00139 · Cited by 70
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells
Fasano, C., Rocchetti, J., Pietrajtis, K., Zander, J.-F., Manseau, F., Sakae, D. Y., Marcus-Sells, M., Ramet, L., Morel, L. J., Carrel, D., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00140 · Cited by 67
Self-citationA Role for Glutamate Transporters in the Regulation of Insulin Secretion
Gammelsæter, R., Coppola, T., Marcaggi, P., Storm‐Mathisen, J., Chaudhry, F. A., Attwell, D., Regazzi, R., & Gundersen, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022960 · Cited by 64
Divito, C. B., Steece‐Collier, K., Case, D. T., Williams, S. G., Stancati, J. A., Zhi, L., Rubio, M. E., Sortwell, C. E., Collier, T. J., Sulzer, D., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2124-15.2015 · Cited by 62
Synaptic and circuit functions of multitransmitter neurons in the mammalian brain
Wallace, M. L., & Sabatini, B. L. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.003 · Cited by 59
Pietrancosta, N., Djibo, M., Daumas, S., Mestikawy, S. E., & Erickson, J. D. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01912-7 · Cited by 64
Self-citationDynamics of glutamatergic signaling in the mushroom body of young adult Drosophila
Sinakevitch, I. G., Grau, Y., Strausfeld, N. J., & Birman, S. (2010) · Neural Development · doi:10.1186/1749-8104-5-10 · Cited by 57
Sharifi, A., Kousi, M., Sagné, C., Bellenchi, G. C., Morel, L. J., Darmon, M. C., Hůlková, H., Ruivo, R., Debacker, C., Mestikawy, S. E., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq381 · Cited by 57
Self-citationCholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating
Favier, M., Janíčková, H., Justo, D., Kljakic, O., Runtz, L., Natsheh, J. Y., Pascoal, T. A., Germann, J., Gallino, D., Kang, J.-I., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138532 · Cited by 54
Self-citationParadoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons
Pelkey, K. A., Calvigioni, D., Fang, C., Vargish, G., Ekins, T., Auville, K., Wester, J. C., Lai, M., Mackenzie-Gray Scott, C., Yuan, X., et al. (2020) · eLife · doi:10.7554/elife.51996 · Cited by 46
Buck, S. A., Torregrossa, M. M., Logan, R. W., & Freyberg, Z. (2020) · FEBS Journal · doi:10.1111/febs.15496 · Cited by 57
Maruska, K. P., Butler, J. M., Field, K. E., & Porter, D. T. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24092 · Cited by 51
Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport
Schenck, S., Kunz, L., Sahlender, D. A., Pardon, E., Geertsma, E. R., Savtchouk, I., Suzuki, T., Neldner, Y., Štefanić, S., Steyaert, J., et al. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00436 · Cited by 47
A new outlook on cholinergic interneurons in Parkinson’s disease and L-DOPA-induced dyskinesia
Conti, M. M., Chambers, N., & Bishop, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.021 · Cited by 50
Divergent properties and independent regulation of striatal dopamine and GABA co-transmission
Zych, S. M., & Ford, C. P. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110823 · Cited by 46
VGluT2 Expression in Dopamine Neurons Contributes to Postlesional Striatal Reinnervation
Kouwenhoven, W. M., Fortin, G., Penttinen, A., Florence, C., Delignat‐Lavaud, B., Bourque, M.-J., Trimbuch, T., Luppi, M. P., Salvail-Lacoste, A., Legault, P., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0823-20.2020 · Cited by 55
Poppi, L. A., Ho-Nguyen, K.-T., Shi, A., Daut, C. T., & Tischfield, M. A. (2021) · Cells · doi:10.3390/cells10040907 · Cited by 47
Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior
Eskenazi, D., Malave, L. B., Mingote, S., Yetnikoff, L., Ztaou, S., Velicu, V., Rayport, S., & Chuhma, N. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.665386 · Cited by 52
Presynaptic Molecular Determinants of Quantal Size
Takamori, S. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00002 · Cited by 45
Regulation of Cognitive Processing by Hippocampal Cholinergic Tone
Al‐Onaizi, M., Parfitt, G. M., Kolisnyk, B., Law, C. S. H., Guzmán, M. S., Barros, D. M., Leung, L.-W. S., Prado, M. A. M., & Prado, V. F. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv349 · Cited by 46
SLC10A4 Is a Vesicular Amine-Associated Transporter Modulating Dopamine Homeostasis
Larhammar, M., Patra, K., Blunder, M., Emilsson, L., Peuckert, C., Arvidsson, E., Rönnlund, D., Preobraschenski, J., Birgner, C., Limbach, C., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.017 · Cited by 43
Fournet, V., Schweitzer, A., Chevarin, C., Deloulme, J., Hamon, M., Giros, B., Andrieux, A., & Martres, M. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07615.x · Cited by 42
Enhanced histamine H2 excitation of striatal cholinergic interneurons in l-DOPA-induced dyskinesia
Lim, S. A. O., Xia, R., Ding, Y., Won, L., Ray, W. J., Hitchcock, S. A., McGehee, D. S., & Kang, U. J. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.01.003 · Cited by 43
Pomierny, B., Krzyżanowska, W., Broniowska, Ż., Strach, B., Bystrowska, B., Starek‐Świechowicz, B., Maciejska, A., Skórkowska, A., Wesołowska, J., Walczak, M., et al. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz160 · Cited by 42
Synaptic Vesicle Proteins: Targets and Routes for Botulinum Neurotoxins
Ahnert‐Hilger, G., Münster‐Wandowski, A., & Höltje, M. (2012) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-33570-9_8 · Cited by 41
Zimmermann, J., Herman, M. A., & Rosenmund, C. (2015) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2015.00016 · Cited by 37
Skirzewski, M., Princz‐Lebel, O., German‐Castelan, L., Crooks, A. M., Kim, K., Tarnow, S. H., Reichelt, A. C., Memar, S., Palmer, D. D., Li, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35601-x · Cited by 41
Kljakic, O., Janíčková, H., Prado, V. F., & Prado, M. A. M. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14003 · Cited by 39
Phenotype and function of raphe projections to the suprachiasmatic nucleus
Yamakawa, G. R., & Antle, M. C. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07228.x · Cited by 39
Crittenden, J. R., Lacey, C. J., Weng, F., Garrison, C. E., Gibson, D. J., Lin, Y., & Graybiel, A. M. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00020 · Cited by 42
A distinct set of synaptic‐like microvesicles in atroglial cells contain VGLUT3
Ormel, L., Stensrud, M. J., Chaudhry, F. A., & Gundersen, V. (2012) · Glia · doi:10.1002/glia.22348 · Cited by 38
Stensrud, M. J., Chaudhry, F. A., Leergaard, T. B., Bjaalie, J. G., & Gundersen, V. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23331 · Cited by 35
d’Incamps, B. L., Bhumbra, G. S., Foster, J. D., Beato, M., & Ascher, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-04266-8 · Cited by 38
Co-existence of Functionally Different Vesicular Neurotransmitter Transporters
Münster‐Wandowski, A., Zander, J.-F., Richter, K., & Ahnert‐Hilger, G. (2016) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2016.00004 · Cited by 33
Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons
Voisin, A. N., Mnie‐Filali, O., Giguère, N., Fortin, G. M., Vigneault, É., Mestikawy, S. E., Descarries, L., & Trudeau, L. (2016) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2016.00039 · Cited by 34
Self-citationMorphological and physiological properties of CCK/CB1R-expressing interneurons in the basal amygdala
Rovira-Esteban, L., Péterfi, Z., Vikór, A., Máté, Z., Szabó, G., & Hájos, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1417-z · Cited by 34
A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry
Ullman, J. C., Yang, J., Sullivan, M., Bendor, J., Levy, J. M., Pham, E., Silm, K., Seifikar, H., Sohal, V. S., Nicoll, R. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02716-5 · Cited by 32
Multiplexed neurotransmission emulated for emotion control
Ni, Y., Ma, M., Wei, H., Gong, J., Han, H., Liu, L., Xu, Z., & Xu, W. (2021) · Nano Energy · doi:10.1016/j.nanoen.2021.106038 · Cited by 34
Rousseau, J., Klinger, S., Rachalski, A., Turgeon, B., Déléris, P., Vigneault, É., Poirier-Héon, J.-F., Davoli, M. A., Mechawar, N., Mestikawy, S. E., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01147-10 · Cited by 32
Self-citationRole of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia
Gangarossa, G., Guzmán, M. S., Prado, V. F., Prado, M. A. M., Daumas, S., Mestikawy, S. E., & Valjent, E. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.12.010 · Cited by 35
Self-citationInta, D., Vogt, M. A., Perreau‐Lenz, S., Schneider, M., Pfeiffer, N., Wojcik, S. M., Spanagel, R., & Gass, P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.012 · Cited by 31
Michalski, D., Härtig, W., Krügel, K., Edwards, R. H., Böddener, M., Böhme, L., Pannicke, T., Reichenbach, A., & Grosche, A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.046 · Cited by 31
Ni, Y., Liu, L., Liu, J., & Xu, W. (2022) · ACS Nano · doi:10.1021/acsnano.2c06122 · Cited by 30
Metadata
- Authors
- Gras, C., Amilhon, B., Lepicard, È. M., Poirel, O., Vinatier, J., Herbin, M., Dumas, S., Tzavara, E. T., Wade, M. R., Nomikos, G. G., Hanoun, N., Saurini, F., Kemel, M.-L., Gasnier, B., Giros, B., & Mestikawy, S. E.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Amgen (United States) (US)
- Corresponding author
- Mestikawy, Salah El
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2008-02-17
- Volume
- 11
- Issue
- 3
- Pages
- 292-300
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2068075585
- Cited by
- 211
- References
- 47
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 11 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 17 · 2014: 16 · 2013: 8 · 2012: 12
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- VGLUT3, vesicular glutamate transporter, striatum, acetylcholine release, vesicular acetylcholine transporter, cholinergic interneurons, cocaine sensitivity, haloperidol-induced catalepsy, synaptic vesicles, cholinergic synapses
- MeSH terms
- Acetylcholine, Animals, Corpus Striatum, Drug Resistance, Interneurons, Motor Activity, Synaptic Transmission, Organ Culture Techniques, Synaptic Vesicles, Antipsychotic Agents, Down-Regulation, Presynaptic Terminals, Mice, Knockout, Glutamic Acid, Dopamine Uptake Inhibitors, Amino Acid Transport Systems, Acidic, Vesicular Acetylcholine Transport Proteins, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
