Cited by 652Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

Meyer-Lindenberg, Andreas, Miletich, Robert S., Kohn, Philip D., Esposito, Giuseppe, Carson, Richard E., Quarantelli, Mario, Weinberger, Daniel R., Berman, Karen Faith·2002·Nature Neuroscience

DOI 10.1038/nn804

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Abstract

Both dopaminergic neurotransmission and prefrontal cortex (PFC) function are known to be abnormal in schizophrenia. To test the hypothesis that these phenomena are related, we measured presynaptic dopaminergic function simultaneously with regional cerebral blood flow during the Wisconsin Card Sorting Test (WCST) and a control task in unmedicated schizophrenic subjects and matched controls. We show that the dopaminergic uptake constant Ki in the striatum was significantly higher for patients than for controls. Patients had significantly less WCST-related activation in PFC. The two parameters were strongly linked in patients, but not controls. The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities.

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Authors: Meyer-Lindenberg, A., Miletich, R. S., Kohn, P. D., Esposito, G., Carson, R. E., Quarantelli, M., Weinberger, D. R., & Berman, K. F.
Affiliations: National Institutes of Health (US)
ORCID: Carson, Richard E.
Quarantelli, Mario
Weinberger, Daniel R.
Berman, Karen Faith
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2002-01-28
Volume: 5
Issue: 3
Pages: 267-271
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn804
OpenAlex: W2004729128
Cited by: 652
References: 50
Citations by year: 2026: 8 · 2025: 14 · 2024: 13 · 2023: 9 · 2022: 15 · 2021: 30 · 2020: 16 · 2019: 32 · 2018: 20 · 2017: 25 · 2016: 31 · 2015: 41 · 2014: 35 · 2013: 38 · 2012: 40
FWCI: 19.67
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: schizophrenia, prefrontal cortex, striatum, dopamine signaling, dopamine uptake, regional cerebral blood flow, Wisconsin Card Sorting Test, prefrontal cortex activation
MeSH terms: Cerebrovascular Circulation, Corpus Striatum, Dihydroxyphenylalanine, Dopamine, Fluorine Radioisotopes, Humans, Neuropsychological Tests, Schizophrenia, Statistics as Topic, Synapses, Tomography, Emission-Computed, Prefrontal Cortex

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Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

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