The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Through-skull fluorescence imaging of the brain in a new near-infrared window
Open accessAbstract
To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography, with their limited spatial resolution and long scanning times. Fluorescence-based brain imaging in the visible and traditional near-infrared regions (400–900 nm) is an alternative, but at present it requires craniotomy, cranial windows and skull-thinning techniques, and the penetration depth is limited to 1–2 mm due to light scattering. Here, we report through-scalp and through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy, utilizing the intrinsic photoluminescence of single-walled carbon nanotubes in the 1.3–1.4 μm near-infrared window (NIR-IIa window). Reduced photon scattering in this spectral region allows fluorescence imaging to a depth of >2 mm in mouse brain with sub-10-μm resolution. An imaging rate of ∼5.3 frames per second allows for dynamic recording of blood perfusion in the cerebral vessels with sufficient temporal resolution, providing real-time assessment of a blood flow anomaly in a mouse middle cerebral artery occlusion stroke model. Near-infrared photoluminescence from carbon nanotubes makes it possible to optically image the vasculature in the brain directly through the skull.
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Cites
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292
Second window for in vivo imaging
Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287
Self-citationKleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563
Self-citationChronic optical access through a polished and reinforced thinned skull
Drew, P. J., Shih, A. Y., Driscoll, J. D., Knutsen, P. M., Blinder, P., Davalos, D., Akassoglou, K., Tsai, P. S., & Kleinfeld, D. (2010) · Nature Methods · doi:10.1038/nmeth.1530 · Cited by 406
Cited by
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Self-citationRichardson, D. S., & Lichtman, J. W. (2015) · Cell · doi:10.1016/j.cell.2015.06.067 · Cited by 1,095
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037
He, S., Song, J., Qu, J., & Cheng, Z. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00234g · Cited by 1,021
Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721
Metadata
- Authors
- Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., Kuo, C. J., & Dai, H.
- Venue
- Nature Photonics
- Published
- 2014-08-03
- Volume
- 8
- Issue
- 9
- Pages
- 723-730
- ISSN
- 1749-4885 (ISSN-L)
- 1749-4893
- OpenAlex
- W1996258924
- Cited by
- 1,061
- References
- 6
- FWCI
- 42.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., Kuo, C. J., & Dai, H. (2014). Through-skull fluorescence imaging of the brain in a new near-infrared window. Nature Photonics. https://doi.org/10.1038/nphoton.2014.166
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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