D-Cycloserine Facilitates Extinction the First Time but not the Second Time: An Examination of the Role of NMDA Across the Course of Repeated Extinction Sessions
Abstract
Extinction of learned fear is facilitated by the partial NMDA agonist D-cycloserine (DCS). However, some studies suggest that the involvement of NMDA in learning differs depending on whether learning is for the first or second time. The current study aimed to extend these findings by examining the role of NMDA in extinction for the first and the second time. Specifically, the present series of experiments used Pavlovian fear conditioning and extinction paradigms to compare the effect of DCS on extinction of fear to a light CS the first and second time around. As found previously, DCS facilitated extinction of learned fear (Experiment 1). A novel finding, however, was that DCS did not facilitate the re-extinction of fear to this same CS following retraining (Experiments 2A and 2B). Finally, it was demonstrated that the transition from NMDA-dependent to NMDA-independent extinction was stimulus specific (Experiment 3). That is, rats were first trained to fear a CS (light); this fear was then extinguished. Following this, rats were then retrained to fear the same CS (light) or a new CS (white noise). When given a second extinction session, DCS was found to facilitate extinction of the new CS but not the original CS. The results of this series of experiments suggest that the role of NMDA in extinction depends on whether extinction is new learning (first extinction) or retrieval of a previous extinction memory (re-extinction).
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NMDA is involved in extinction in postweaning and adult rats.
“but is in postweaning and adult rats (Baker and Azorlosa, 1996;Langton et al, 2007;Langton and Richardson, 2008).”
From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Langton and Richardson, 2008
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- Authors
- Langton, J. M., & Richardson, R.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Langton, Julia M
- Venue
- Neuropsychopharmacology
- Published
- 2008-03-19
- Volume
- 33
- Issue
- 13
- Pages
- 3096-3102
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2126343655
- Cited by
- 63
- References
- 39
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 8 · 2013: 8 · 2012: 5
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of New South Wales
- Australian Research Council (DP0666953)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- D-cycloserine, NMDA receptor, fear extinction, fear conditioning, stimulus specificity, rats
- MeSH terms
- Acoustic Stimulation, Animals, Anxiety Disorders, Avoidance Learning, Brain, Conditioning, Psychological, Cycloserine, Disease Models, Animal, Extinction, Psychological, Fear, Male, Memory, Neuropsychological Tests, Photic Stimulation, Reflex, Startle, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Rats
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