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Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

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Micale, Vincenzo, Cristino, Luigia, Tamburella, Alessandra, Petrosino, Stefania, Leggio, Gian Marco, Drago, Filippo, Di Marzo, Vincenzo·2009·Neuropsychopharmacology

DOI 10.1038/npp.2008.98

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Abstract

The endocannabinoid-inactivating enzyme, fatty acid amide hydrolase (FAAH), and the transient receptor potential vanilloid type-1 (TRPV1) channel are new targets for the development of anxiolytic drugs. We studied the effect on anxiety-like behavior in the elevated plus maze of a dual FAAH/TRPV1 blocker, N-arachidonoyl-serotonin (AA-5-HT). In male C57BL/6J mice, acute intraperitoneal administration of AA-5-HT (0.1-2.5 mg/kg) increased both the time spent and the number of entries in the open arm, while being inactive at the highest dose tested (5 mg/kg). AA-5-HT was more potent than selective blockers of FAAH or TRPV1 (URB597 and SB366791, respectively). In male Swiss mice, AA-5-HT had to be administered chronically to observe an anxiolytic effect at an intermediate dose (2.5 mg/kg), the highest dose (5 mg/kg) being anxiogenic, and 1 mg/kg being ineffective. In both strains, the anxiolytic effects of AA-5-HT were paralleled by elevation of brain endocannabinoid levels and were reversed by per se inactive doses of the cannabinoid receptors of type-1 (CB(1)) receptor antagonist AM251, or the TRPV1 agonist, olvanil. Immunohistochemical localization of CB(1) and TRPV1 receptors was observed in mouse prefrontal cortex, nucleus accumbens, amygdala, and hippocampus. Simultaneous 'indirect' activation of CB(1) receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety.

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Self-citation
CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial division of the ventromedial hypothalamus
dos Anjos‐Garcia, T., Ullah, F., Falconi‐Sobrinho, L. L., & Coimbra, N. C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.003 · Cited by 44
[Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?].
Saito, V. M., Wotjak, C. T., & Moreira, F. A. (2010) · PubMed · Cited by 43
N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus
Gobira, P. H., Lima, I. V. D. A., Batista, L. A., de Oliveira, A. C., Resstel, L. B. M., Wotjak, C. T., de Aguiar, D. C., & Moreira, F. A. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117691567 · Cited by 45
N-Arachidonoyl-serotonin in the basolateral amygdala increases anxiolytic behavior in the elevated plus maze
John, C. S., & Currie, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.025 · Cited by 43
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor
Umathe, S. N., Manna, S. S. S., & Jain, N. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.030 · Cited by 42
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
Rea, K., Olango, W. M., Harhen, B., Kerr, D. M., Galligan, R., Fitzgerald, S. T., Moore, M., Roche, M., & Finn, D. P. (2012) · Pain · doi:10.1016/j.pain.2012.12.021 · Cited by 41
Endocannabinoids and striatal function
Moreira, F. A., Jupp, B., Belin, D., & Dalley, J. W. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000109 · Cited by 44
TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation
Xiao, Y., Chen, X., Zhang, P., Xu, Q., Zheng, H., & Xu, G. (2016) · Scientific Reports · doi:10.1038/srep29026 · Cited by 41
Multiple chemical sensitivity: It's time to catch up to the science
Molot, J., Sears, M., & Anisman, H. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105227 · Cited by 40
Interleukin-1β alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum
De Chiara, V., Motta, C., Rossi, S., Studer, V., Barbieri, F., Lauro, D., Bernardi, G., & Centonze, D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.069 · Cited by 37
Anandamide serves two masters in the brain
Marzo, V. D. (2010) · Nature Neuroscience · doi:10.1038/nn1210-1446 · Cited by 38
Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs
Batista, L. A., Gobira, P. H., Viana, T. G., de Aguiar, D. C., & Moreira, F. A. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000073 · Cited by 38
Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation
Murillo‐Rodríguez, E., Marzo, V. D., Machado, S. E. D. C., Rocha, N., Veras, A. B., Neto, G. D. A. M., Budde, H., Arias-Carrión, Ó., & Arankowsky‐Sandoval, G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00152 · Cited by 38
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Rodrigues, R. J., Marques, J. M., & Köfalvi, A. (2024) · Cells · doi:10.3390/cells13221875 · Cited by 43
The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats
Tahmasebi, L., Komaki‬, A., Karamian, R., Shahidi, ‬., Sarihi, A., Salehi, I., & Nikkhah, A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.063 · Cited by 37
Brain TRPV1: a depressing TR(i)P down memory lane?
Marzo, V. D., Gobbi, G., & SZALLASI, A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.004 · Cited by 37
Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls
Iacob, E., Light, K. C., Tadler, S. C., Weeks, H. R., White, A. T., Hughen, R. W., VanHaitsma, T. A., Bushnell, L., & Light, A. R. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-273 · Cited by 38
Identification of an arylalkylamine N‐acyltransferase from Drosophila melanogaster that catalyzes the formation of long‐chain N‐acylserotonins
Dempsey, D. R., Jeffries, K. A., Anderson, R. L., Carpenter, A., Opsina, S. R., & Merkler, D. J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2013.12.027 · Cited by 36
Getting high on the endocannabinoid system.
Alger, B. E. (2013) · Europe PMC (PubMed Central) · Cited by 35
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
Flannery, L. E., Kerr, D. M., Finn, D. P., & Roche, M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.030 · Cited by 34
TRPV1 blockers as potential new treatments for psychiatric disorders
Iglesias, L. P., de Aguiar, D. C., & Moreira, F. A. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000603 · Cited by 35
Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety
Vincenzi, F., Ravani, A., Pasquini, S., Merighi, S., Gessi, S., Romagnoli, R., Baraldi, P. G., Borea, P. A., & Varani, K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.015 · Cited by 34
Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease
Wang, M., Liu, H., & Ma, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.832854 · Cited by 36
Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as “dual-target” analgesics
Maione, S., Costa, B., Piscitelli, F., Morera, E., Chiaro, M. D., Comelli, F., Boccella, S., Guida, F., Verde, R., Ortar, G., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.003 · Cited by 33
Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow Boidae snakes
dos Anjos‐Garcia, T., & Coimbra, N. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5170-2 · Cited by 32
Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping
Ferber, S. G., Trezza, V., & Weller, A. (2019) · Developmental Psychobiology · doi:10.1002/dev.21944 · Cited by 38
The transient receptor potential vanilloid-1 is localized at excitatory synapses in the mouse dentate gyrus
Puente, N., Reguero, L., Elezgarai, I., Canduela, M. J., Mendizabal‐Zubiaga, J., Ramos, A., Fernández‐Espejo, E., & Grandes, P. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0711-2 · Cited by 33
Endocannabinoid Modulation of Dopaminergic Motor Circuits
Morera‐Herreras, T., Miguélez, C., Aristieta, A., Ruíz-Ortega, J. Á., & Ugedo, L. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00110 · Cited by 35

Authors: Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G. M., Drago, F., & Di Marzo, V.
Affiliations: University of Catania (IT)
Institute of Applied Science and Intelligent Systems (IT)
Istituto di Chimica Biomolecolare (IT)
ORCID: Micale, Vincenzo
Cristino, Luigia
Petrosino, Stefania
Leggio, Gian Marco
Drago, Filippo
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2008-06-25
Volume: 34
Issue: 3
Pages: 593-606
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2008.98
OpenAlex: W2024922848
Cited by: 207
References: 60
Citations by year: 2026: 3 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 4 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 19 · 2015: 14 · 2014: 23 · 2013: 15 · 2012: 18
FWCI: 9.61
Type: journal article
Language: en
Open access: green
www.openaccessrepository.it
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Funders: Università di Catania
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: anxiolytic effects, fatty acid amide hydrolase, TRPV1, endocannabinoids, CB1 receptor, anxiety-like behavior, elevated plus maze, olvanil, URB597, SB366791, prefrontal cortex, amygdala, nucleus accumbens, hippocampus, cannabinoid receptor antagonism
MeSH terms: Fatty Acid Amide Hydrolases, Amidohydrolases, Anilides, Animals, Anxiety, Arachidonic Acids, Benzamides, Brain, Capsaicin, Carbamates, Cinnamates, Diazepam, Exploratory Behavior, Male, Mice, Inbred C57BL, Piperidines, Pyrazoles, Serotonin, Anti-Anxiety Agents, Receptor, Cannabinoid, CB1, TRPV Cation Channels, Mice, Cannabinoid Receptor Modulators

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Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

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