White matter disruptions in adolescents exposed to childhood maltreatment and vulnerability to psychopathology
Open accessAbstract
Childhood maltreatment has been known to produce long-lasting impairments in behavioral, cognitive and social functioning, but their underlying mechanisms are not well-understood. A better understanding of their underlying mechanisms will aid in developing effective preventive interventions. Nineteen adolescent volunteers with no personal history of a psychiatric illness, but who were exposed to maltreatment during childhood, and 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) underwent diffusion tensor imaging (DTI) studies. The participants were then followed longitudinally at 6-month intervals for up to 5 years to determine the onset of mood and substance use disorders. The associations among fractional anisotropy (FA) values obtained from the DTI scans at baseline and psychopathology at follow-up were examined. At baseline, adolescents exposed to childhood maltreatment had significantly lower FA values in the left and right superior longitudinal fasciculi, right cingulum bundle projecting to the hippocampus, left inferior fronto-occipital fasciculus, and splenium of the corpus callosum compared with controls. Adolescents who developed major depressive disorder at follow-up had significantly lower FA values in the superior longitudinal fasciculi and the right cingulum-hippocampal projection compared with their counterparts who did not develop the illness. Adolescents who developed substance use disorder during follow-up had significantly lower FA values in the right cingulum-hippocampal projection than their counterparts without the disorder. These preliminary results suggest that white matter disruptions observed in adolescents exposed to childhood maltreatment may be associated with increased vulnerability to psychopathology, specifically depressive and substance use disorders.
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Perinatal insults and psychosocial stress during childhood and adolescence are correlated with structural changes in white matter.
“Perinatal insults and psychosocial stress during childhood and adolescence are correlated with structural changes in white matter (Chew et al., 2013; Eluvathingal et al., 2006; Huang et al., 2012).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Huang et al., 2012
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- Authors
- Huang, H., Gundapuneedi, T., & Rao, U.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Meharry Medical College (US)
- Corresponding author
- Rao, Uma
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2012-08-01
- Volume
- 37
- Issue
- 12
- Pages
- 2693-2701
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3473335
- OpenAlex
- W1998164213
- Cited by
- 173
- References
- 54
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 17 · 2019: 12 · 2018: 17 · 2017: 16 · 2016: 14 · 2015: 16 · 2014: 15 · 2013: 7
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of Texas Southwestern Medical Center
- National Institutes of Health (RR003032, MD007593, RR024975)
- National Institute of Mental Health (R01MH062464, R01MH068391, R01MH092535)
- National Institute on Drug Abuse (R01DA015131, R01DA017804, R01DA014037, R01DA017805)
- National Institute of Biomedical Imaging and Bioengineering (R21EB009545)
- National Center for Research Resources (G12RR003032, U54RR026140, KL2RR024977, TL1RR024978, UL1RR024975)
- National Institute on Minority Health and Health Disparities (U54 RR026140/U54 MD007593, U54MD007593)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Safety Research › Child Welfare and Adoption
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- child abuse, white matter disruption, adolescents, fractional anisotropy, superior longitudinal fasciculus, cingulum, hippocampus, inferior fronto-occipital fasciculus, corpus callosum, major depressive disorder, substance use disorders, vulnerability to psychopathology, diffusion tensor imaging
- MeSH terms
- Adolescent, Mental Disorders, Brain, Child, Child Abuse, Depression, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Life Change Events, Male, Neuropsychological Tests, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Socioeconomic Factors, Cluster Analysis, Anisotropy, Diffusion Tensor Imaging
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