Active induction of experimental allergic encephalomyelitis

Immunology of multiple sclerosis

Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149

The T Lymphocyte In Experimental Allergic Encephalomyelitis

Zamvil, S. (1990) · Annual Review of Immunology · doi:10.1146/annurev.immunol.8.1.579 · Cited by 1,009

The Neurotoxicant, Cuprizone, as a Model to Study Demyelination and Remyelination in the Central Nervous System

Matsushima, G. K., & Morell, P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00385.x · Cited by 984

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

Ben‐Nun, A., Wekerle, H., & Cohen, I. R. (1981) · European Journal of Immunology · doi:10.1002/eji.1830110307 · Cited by 916

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

Weiner, H. L. (1994) · Annual Review of Immunology · doi:10.1146/annurev.immunol.12.1.809 · Cited by 906

Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A., & Kuchroo, V. K. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021603 · Cited by 825

Cellular immune reactivity within the CNS

Wekerle, H., Linington, C., Lassmann, H., & Meyermann, R. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90077-9 · Cited by 768

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

Linington, C., Bradl, M., Lassmann, H., Brunner, C., & Vass, K. (1988) · PubMed · Cited by 708

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

McMahon, E. J., Bailey, S. L., Castenada, C. V., Waldner, H., & Miller, S. D. (2005) · Nature Medicine · doi:10.1038/nm1202 · Cited by 694

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

Goverman, J., Woods, A., Larson, L., Weiner, L. P., Hood, L., & Zaller, D. M. (1993) · Cell · doi:10.1016/0092-8674(93)90074-z · Cited by 683

The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms

Engelhardt, B., & Ransohoff, R. M. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.07.004 · Cited by 673

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

Huseby, E. S., Liggitt, D., Brabb, T., Schnabel, B., Öhlén, C., & Goverman, J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.669 · Cited by 659

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

Rivers, T. M., Sprunt, D. H., & Berry, G. P. (1933) · Journal of Experimental Medicine · doi:10.1084/jem.58.1.39 · Cited by 643

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

Willenborg, D. O., Fordham, S., Bernard, C. C., Cowden, W. B., & Ramshaw, I. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.8.3223 · Cited by 635

A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells

Mendel, I., de Rosbo, N. K., & Ben‐Nun, A. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250723 · Cited by 601

Current protocols in immunology: edited by J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach and W. Strober, Greene Publishing Associates and Wiley‐Interscience; New York, 1991; 900 pages approx. + 200 pages approx. (Supplement 1) $245.00 (USA), $270.00 (elsewhere). ISBN 0‐471‐52276‐7

Wisdom, G. B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80333-p · Cited by 579

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

Urban, J. L., Kumar, V., Kono, D. H., Gomez, C., Horvath, S. J., Clayton, J., Ando, D. G., Sercarz, E. E., & Hood, L. (1988) · Cell · doi:10.1016/0092-8674(88)90079-7 · Cited by 547

TRANSFER OF ALLERGIC ENCEPHALOMYELITIS IN RATS BY MEANS OF LYMPH NODE CELLS

Paterson, P. Y. (1960) · The Journal of Experimental Medicine · doi:10.1084/jem.111.1.119 · Cited by 546

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

Lafaille, J. J., Nagashima, K., Katsuki, M., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90419-7 · Cited by 532

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

Zamvil, S., Nelson, P., Trotter, J., Mitchell, D., Knobler, R., Fritz, R., & Steinman, L. (1985) · Nature · doi:10.1038/317355a0 · Cited by 530

Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology

Storch, M. K., Stefferl, A., Brehm, U., Weissert, R., Wallström, E., Kerschensteiner, M., Olsson, T., Linington, C., & Lassmann, H. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00194.x · Cited by 522

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

McRae, B. L., Vanderlugt, C. L., Dal Canto, M. C., & Miller, S. D. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.1.75 · Cited by 518

How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis.

Steinman, L., & Zamvil, S. S. (2006) · Annals of Neurology · doi:10.1002/ana.20913 · Cited by 479

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

Krakowski, M., & Owens, T. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260735 · Cited by 471

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

Zamvil, S. S., Mitchell, D. J., Moore, A. C., Kitamura, K., Steinman, L., & Rothbard, J. B. (1986) · Nature · doi:10.1038/324258a0 · Cited by 464

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

Lehmann, P. V., Sercarz, E. E., Forsthuber, T., Dayan, C. M., & Gammon, G. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90163-f · Cited by 461

Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice

Sun, D., Whitaker, J. N., Huang, Z., Liu, D., Coleclough, C., Wekerle, H., & Raine, C. S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7579 · Cited by 444

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

Liu, G. Y., Fairchild, P. J., Smith, R. M., Prowle, J. R., Kioussis, D., & Wraith, D. C. (1995) · Immunity · doi:10.1016/1074-7613(95)90170-1 · Cited by 413

THE RAPID PRODUCTION OF ACUTE DISSEMINATED ENCEPHALOMYELITIS IN RHESUS MONKEYS BY INJECTION OF HETEROLOGOUS AND HOMOLOGOUS BRAIN TISSUE WITH ADJUVANTS

Kabat, E. A., Wolf, A., & Bezer, A. E. (1947) · Journal of Experimental Medicine · doi:10.1084/jem.85.1.117 · Cited by 403

Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.

Amor, S., Groome, N., Linington, C., Morris, M. M., Dornmair, K., Gardinier, M. V., Matthieu, J. M., & Baker, D. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.10.4349 · Cited by 380

A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease.

Schluesener, H. J., Sobel, R. A., Linington, C., & Weiner, H. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.12.4016 · Cited by 371

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

Tuohy, V. K., Lu, Z., Sobel, R. A., Laursen, R. A., & Lees, M. B. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.5.1523 · Cited by 367

T Cell Response in Experimental Autoimmune Encephalomyelitis (EAE): Role of Self and Cross-Reactive Antigens in Shaping, Tuning, and Regulating the Autopathogenic T Cell Repertoire

Kuchroo, V. K., Anderson, A. C., Waldner, H., Munder, M., Bettelli, E., & Nicholson, L. B. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081701.141316 · Cited by 366

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

Hickey, W. F. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00646.x · Cited by 357

A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody

Linnington, C., Webb, M., & Woodhams, P. L. (1984) · Journal of Neuroimmunology · doi:10.1016/0165-5728(84)90064-x · Cited by 321

Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.

Genain, C. P., Nguyen, M. H., Letvin, N. L., Pearl, R., Davis, R. L., Adelman, M., Lees, M. B., Linington, C., & Hauser, S. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118368 · Cited by 314

T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis

Iglesias, A., Bauer, J., Litzenburger, T., Schubart, A., & Linington, C. (2001) · Glia · doi:10.1002/glia.1111 · Cited by 280

Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis

Sriram, S., & Steiner, I. (2005) · Annals of Neurology · doi:10.1002/ana.20743 · Cited by 264

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

Friese, M. A., & Fugger, L. H. (2005) · Brain · doi:10.1093/brain/awh578 · Cited by 252

The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat

Adelmann, M., Wood, J., Benzel, I., Fiori, P., Lassmann, H., Matthieu, J.-M., Gardinier, M. V., Dornmair, K., & Linington, C. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00124-7 · Cited by 232

Passive induction of experimental allergic encephalomyelitis

Stromnes, I. M., & Goverman, J. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.284 · Cited by 225

De Novo Central Nervous System Processing of Myelin Antigen Is Required for the Initiation of Experimental Autoimmune Encephalomyelitis1

Tompkins, S., Padilla, J., Canto, M. C. D., Ting, J., Kaer, L. V., & Miller, S. D. (2002) · Journal of Immunology · doi:10.4049/jimmunol.168.8.4173 · Cited by 219

The CD4–Th1 model for multiple sclerosis: a crucial re-appraisal

Lassmann, H., & Ransohoff, R. M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.01.007 · Cited by 203

Self-antigen-induced Th2 responses in experimental allergic encephalomyelitis (EAE)-resistant mice. Th2-mediated suppression of autoimmune disease

J, D., Hinton, D. R., & Stohlman, S. A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.8.4052 · Cited by 197

Differential Expression of Inflammatory Cytokines Parallels Progression of Central Nervous System Pathology in Two Clinically Distinct Models of Multiple Sclerosis

Begolka, W. S., Vanderlugt, C. L., Rahbe, S. M., & Miller, S. D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4437 · Cited by 197

The Activation Status of Neuroantigen-specific T Cells in the Target Organ Determines the Clinical Outcome of Autoimmune Encephalomyelitis

Kawakami, N., Lassmann, S., Li, Z., Odoardi, F., Ritter, T., Ziemssen, T., Klinkert, W. E. F., Ellwart, J. W., Bradl, M., Krivacic, K., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031064 · Cited by 188

Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system.

Berger, T., Weerth, S., Kojima, K., Linington, C., Wekerle, H., & Lassmann, H. (1997) · PubMed · Cited by 185

Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice

Oliver, A. R., Lyon, G. M., & Ruddle, N. H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.462 · Cited by 171

Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein

O’Connor, K. C., Appel, H., Bregoli, L., Call, M. E., Catz, I., Chan, J. A.-W., Moore, N., Warren, K. G., Wong, S. J., Hafler, D. A., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1974 · Cited by 168

The value of animal models for drug development in multiple sclerosis

Friese, M. A. (2006) · Brain · doi:10.1093/brain/awl083 · Cited by 159

In Situ Tolerance within the Central Nervous System as a Mechanism for Preventing Autoimmunity

Brabb, T., von Dassow, P., Ordonez, N., Schnabel, B., Duke, B., & Goverman, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.6.871 · Cited by 159

Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

Waldner, H., Whitters, M. J., Sobel, R. A., Collins, M. A., & Kuchroo, V. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3412 · Cited by 156

Regulatory T cells in spontaneous autoimmune encephalomyelitis

Furtado, G. D. C., Olivares–Villagómez, D., de Lafaille, M. A. C., Wensky, A. K., Latkowski, J.-A. M., & Lafaille, J. J. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820110.x · Cited by 155

CpG Oligonucleotides Are Potent Adjuvants for the Activation of Autoreactive Encephalitogenic T Cells In Vivo

Segal, B. M., Chang, J. T., & Shevach, E. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5683 · Cited by 153

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.018 · Cited by 152

Experimental Autoimmune Encephalomyelitis in Mice: Immunologic Response to Mouse Spinal Cord and Myelin Basic Proteins

Bernard, C. C. A., & CARNEGIE, P. R. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.114.5.1537 · Cited by 147

Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice.

Kono, D. H., Urban, J. L., Horvath, S. J., Ando, D. G., Saavedra, R., & Hood, L. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.1.213 · Cited by 144

Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune Encephalomyelitis in the “Resistant” Brown Norway Rat: Disease Susceptibility Is Determined by MHC and MHC-Linked Effects on the B Cell Response

Stefferl, A., Brehm, U., Storch, M. K., Lambracht‐Washington, D., Bourquin, C., Wonigeit, K., Lassmann, H., & Linington, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.40 · Cited by 143

Gender differences in autoimmune demyelination in the mouse: Implications for multiple sclerosis

Voskuhl, R. R., Pitchekian‐Halabi, H., Mackenzie‐Graham, A., McFarland, H. F., & Raine, C. S. (1996) · Annals of Neurology · doi:10.1002/ana.410390608 · Cited by 143

Specificity, magnitude, and kinetics of MOG‐specific CD8+ T cell responses during experimental autoimmune encephalomyelitis

Ford, M. L., & Evavold, B. D. (2004) · European Journal of Immunology · doi:10.1002/eji.200425660 · Cited by 139

Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant

Lorentzen, J. C., Issazadeh‐Navikas, S., Storch, M. K., Mustafa, M., Lassman, H., Linington, C., Klareskog, L., & Olsson, T. P. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00153-0 · Cited by 138

Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.

Sakai, K., Zamvil, S. S., Mitchell, D. J., Hodgkinson, S. J., Rothbard, J. B., & Steinman, L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9470 · Cited by 136

Multiple sclerosis : clinical and pathogenetic basis

Raine, C. S., McFarland, H. F., & Tourtellotte, W. W. (1997) · Chapman & Hall Medical eBooks · Cited by 135

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein

Greer, J. M., Sobel, R. A., Sette, A., Southwood, S., Lees, M. B., & Kuchroo, V. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.1.371 · Cited by 134

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice

Greer, J. M., Kuchroo, V. K., Sobel, R. A., & Lees, M. B. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.3.783 · Cited by 133

Gonadal hormones influence the immune response to PLP 139–151 and the clinical course of relapsing experimental autoimmmune encephalomyelitis

Bebo, B. F., Zelinka-Vincent, E., Adamus, G., Amundson, D., Vandenbark, A. A., & Offner, H. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00214-2 · Cited by 130

Multiple Sclerosis. Clinical and pathogenetic basis.

ROBERTSON, N. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.6.815 · Cited by 128

Experimental Allergic Encephalomyelitis in Inbred and Outbred Mice

Levine, S., & Sowinski, R. (1973) · The Journal of Immunology · doi:10.4049/jimmunol.110.1.139 · Cited by 121

Cutting Edge: CD4+CD25+ Regulatory T Cells Contribute to Gender Differences in Susceptibility to Experimental Autoimmune Encephalomyelitis

Reddy, J., Waldner, H., Zhang, X., Illés, Z., Wucherpfennig, K. W., Sobel, R. A., & Kuchroo, V. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5591 · Cited by 114

The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls

Haase, C. G., Guggenmos, J., Brehm, U., Andersson, M., Olsson, T. P., Reindl, M., Schneidewind, J. M., Zettl, U. K., Heidenreich, F., Berger, T., et al. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00462-8 · Cited by 113

Identification of Genetic Loci Controlling the Characteristics and Severity of Brain and Spinal Cord Lesions in Experimental Allergic Encephalomyelitis

Butterfield, R. J., Blankenhorn, E. P., Roper, R. J., Zachary, J. F., Doerge, R. W., & Teuscher, C. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64574-9 · Cited by 107

Exacerbation of Viral and Autoimmune Animal Models for Multiple Sclerosis by Bacterial DNA

Tsunoda, I., Tolley, N. D., Theil, D. J., Whitton, J. L., Kobayashi, H., & Fujinami, R. S. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00537.x · Cited by 100

IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis

Wensky, A. K., Furtado, G. C., Marcondes, M. C. G., Chen, S., Manfra, D. J., Lira, S. A., Zagzag, D., & Lafaille, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1416 · Cited by 97

Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse Vβ gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor Vβb and T cell receptor Vβa H‐2b mice

Mendel, I., de Rosbo, N. K., & Ben‐Nun, A. (1996) · European Journal of Immunology · doi:10.1002/eji.1830261030 · Cited by 96

Mechanisms of Immunopathology in Murine Models of Central Nervous System Demyelinating Disease

Ercolini, A. M., & Miller, S. D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3293 · Cited by 95

Studies on autoimmune encephalomyelitis in the guinea pig. II. An in vitro investigation on the nature, properties, and specificity of the serum-demyelinating factor.

Lebar, R., Boutry, J. M., Vincent, C., et al. (1976) · PubMed · Cited by 93

Middle-Age Male Mice Have Increased Severity of Experimental Autoimmune Encephalomyelitis and Are Unresponsive to Testosterone Therapy

Matejuk, A., Hopke, C., Vandenbark, A. A., Hurn, P. D., & Offner, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2387 · Cited by 91

Fc Receptors are Critical for Autoimmune Inflammatory Damage to the Central Nervous System in Experimental Autoimmune Encephalomyelitis

Abdul‐Majid, K., Stefferl, A., Bourquin, C., Lassmann, H., Linington, C., Olsson, T. P., Kleinau, S., & Harris, R. A. (2002) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2002.01024.x · Cited by 91

Encephalitogenic Epitopes of Myelin Basic Protein

Fritz, R. B., & McFarlin, D. E. (1989) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000318828 · Cited by 90

Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis

Brabb, T., Goldrath, A. W., von Dassow, P., Paez, A., Liggitt, H. D., & Goverman, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.497 · Cited by 90

Delayed, relapsing experimental allergic encephalomyelitis in mice.

LUBLIN, F. D., Maurer, P. H., Berry, R. G., & Tippett, D. S. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.3.819 · Cited by 87

Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections

Sewell, D. L., Reinke, E. K., Hogan, L. H., Sándor, M., & Fábry, Z. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00025-1 · Cited by 87

Antibody Association with a Novel Model for Primary Progressive Multiple Sclerosis: Induction of Relapsing‐Remitting and Progressive Forms of EAE in H2S Mouse Strains

Tsunoda, I., Kuang, L., Theil, D. J., & Fujinami, R. S. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00272.x · Cited by 86

Experimental allergic encephalomyelitis in the New World monkey Callithrix jacchus

Genain, C. P., & Hauser, S. L. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1830113.x · Cited by 85

Modelling of multiple sclerosis: lessons learned in a non-human primate

Hart, B. A. ‘., Laman, J. D., Bauer, J., Blezer, E. L. A., van Kooyk, Y., & Hintzen, R. Q. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00879-8 · Cited by 85

Pathological and regulatory effects of anti-myelin antibodies in experimental allergic encephalomyelitis in mice

Morris-Downes, M. M. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00040-1 · Cited by 84

Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein.

Elliott, E. A., McFarland, H., Nye, S. H., Cofiell, R., Wilson, T. M., Wilkins, J. A., Squinto, S. P., Matis, L. A., & Mueller, J. P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118954 · Cited by 82

A neuropathological analysis of experimental autoimmune encephalomyelitis with predominant brain stem and cerebellar involvement and differences between active and passive induction

Muller, D., Pender, M. P., & Greer, J. M. (2000) · Acta Neuropathologica · doi:10.1007/s004019900163 · Cited by 80

Identification of a major encephalitogenic epitope of proteolipid protein (residues 56-70) for the induction of experimental allergic encephalomyelitis in Biozzi AB/H and nonobese diabetic mice

Amor, S., Baker, D., Groome, N. P., & Turk, J. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.12.5666 · Cited by 79

The Role of CD8+ T Cells in Multiple Sclerosis and its Animal Models

Goverman, J. M., Perchellet, A., & Huseby, E. S. (2005) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010053586264 · Cited by 79

Transgenic Models to Study the Actions of Cytokines in the Central Nervous System

Campbell, I. L., Stalder, A. K., Akwa, Y., Pagenstecher, A., & Asensio, V. C. (1998) · NeuroImmunoModulation · doi:10.1159/000026329 · Cited by 78

Encephalitogenic epitopes of myelin basic protein, proteolipid protein, myelin oligodendrocyte glycoprotein for experimental allergic encephalomyelitis induction in Biozzi ABH (H-2Ag7) mice share an amino acid motif

Amor, S., O'Neill, J. K., Morris, M. M., Smith, R. M., Wraith, D. C., Groome, N. P., Travers, P. J., & Baker, D. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.8.3000 · Cited by 72

Microheterogeneity of Guinea Pig Myelin Basic Protein

Martenson, R. E., Deibler, G. E., & Kies, M. W. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94314-0 · Cited by 72

Screening of several H-2 congenic mouse strains identified H-2q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement

Abdul-Majid, K.-B., Jirholt, J., Stadelmann, C., Stefferl, A., Kjellén, P., Wallström, E., Holmdahl, R., Lassmann, H., Olsson, T. P., & Harris, R. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00360-x · Cited by 72

Studies on Autoimmune Encephalomyelitis in the Guinea Pig

Lebar, R., Boutry, J. M., Vincent, C., et al. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.116.5.1439 · Cited by 71

Tolerance Induction and Autoimmune Encephalomyelitis Amelioration After Administration of Myelin Basic Protein–derived Peptide

Marušić, S., & Tonegawa, S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.4.507 · Cited by 70

Mapping and identification of autoimmunity genes

Encinas, J. A., & Kuchroo, V. K. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00164-3 · Cited by 69

Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines

Maron, R., Hancock, W. W., Slavin, A., Hattori, M., Kuchroo, V. K., & Weiner, H. L. (1999) · International Immunology · doi:10.1093/intimm/11.9.1573 · Cited by 69

Age Dependence of Clinical and Pathological Manifestations of Autoimmune Demyelination

Smith, M. E., Eller, N. L., McFarland, H. F., Racke, M. K., & Raine, C. S. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65218-2 · Cited by 65

Gender, Age, and Season at Immunization Uniquely Influence the Genetic Control of Susceptibility to Histopathological Lesions and Clinical Signs of Experimental Allergic Encephalomyelitis

Teuscher, C., Bunn, J. Y., Fillmore, P. D., Butterfield, R. J., Zachary, J. F., & Blankenhorn, E. P. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63416-5 · Cited by 65

Induction of experimental autoimmune encephalomyelitis in Dark Agouti rats without adjuvant

Stošić‐Grujičić, S., Ramić, Z., Bumbaširević, V., Harhaji-Trajkovic, L. M., & Mostarica‐Stojković, M. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02418.x · Cited by 61

Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats

Sakuma, H. (2004) · Brain · doi:10.1093/brain/awh260 · Cited by 59

The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis

Mcdole, J. R., Johnson, A. J., & Pirko, I. (2006) · Neurological Research · doi:10.1179/016164106x98125 · Cited by 52

Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis

Raijmakers, R., Stammen‐Vogelzangs, J., Croxford, J. L., Wesseling, P., VENROOIJ, W. J. V., & Pruijn, G. J. M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20529 · Cited by 51

T-Cell Properties Determine Disease Site, Clinical Presentation, and Cellular Pathology of Experimental Autoimmune Encephalomyelitis

Abromson‐Leeman, S. R., Bronson, R. T., Luo, Y., Berman, M. A., Leeman‐Neill, R. J., Leeman, J. R., & Dorf, M. E. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63410-4 · Cited by 48

Hyperacute Allergic Encephalomyelitis: Adjuvant Effect of Pertussis Vaccines and Extracts

Levine, S., Wenk, E. J., Devlin, H. B., Pieroni, R. E., & Levine, L. (1966) · The Journal of Immunology · doi:10.4049/jimmunol.97.3.363 · Cited by 45

Does the Frequency and Avidity Spectrum of the Neuroantigen-Specific T Cells in the Blood Mirror the Autoimmune Process in the Central Nervous System of Mice Undergoing Experimental Allergic Encephalomyelitis?

Hofstetter, H. H., Targoni, O. S., Karulin, A. Y., Forsthuber, T. G., Tary‐Lehmann, M., & Lehmann, P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4598 · Cited by 35

Strain Variation in Autoimmunity: Attempted Tolerization of DA Rats Results in the Induction of Experimental Autoimmune Encephalomyelitis

Lenz, D. C., Wolf, N. A., & Swanborg, R. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1763 · Cited by 32

Immune Tolerance to Myelin Proteins

Seamons, A., Perchellet, A., & Goverman, J. M. (2003) · Immunologic Research · doi:10.1385/ir:28:3:201 · Cited by 30

Cutting Edge: Myelin Basic Protein-Specific Cytotoxic T Cell Tolerance Is Maintained In Vivo by a Single Dominant Epitope in H-2k Mice

Huseby, E. S., Öhlén, C., & Goverman, J. M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1115 · Cited by 30

Genetic Analysis of the Influence of Neuroantigen-Complete Freund's Adjuvant Emulsion Structures on the Sexual Dimorphism and Susceptibility to Experimental Allergic Encephalomyelitis

Fillmore, P. D., Brace, M., Troutman, S. A., Blankenhorn, E. P., Diehl, S. A., Rincón, M., & Teuscher, C. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63519-5 · Cited by 29

Anaesthesia, Analgesia and Euthanasia

Otto, K. A., & von Thaden, A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382008-2.00032-5 · Cited by 28

Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice

Smith, P. A., Morris-Downes, M. M., Heijmans, N., Pryce, G., Arter, E., O'Neill, J. K., Hart, B. A. ‘., Baker, D., & Amor, S. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.04.006 · Cited by 27

A Structurally Available Encephalitogenic Epitope of Myelin Oligodendrocyte Glycoprotein Specifically Induces a Diversified Pathogenic Autoimmune Response

Bischof, F., Bins, A. D., Dürr, M., Zevering, Y., Melms, A., & Kruisbeek, A. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.600 · Cited by 25

Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases

Miller, S. D., & Eagar, T. N. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1243-1_10 · Cited by 20

Encephalitogenic Epitopes of Myelin Basic Protein

Fritz, R. B., & McFarlin, D. E. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000417289 · Cited by 16

Current Gene‐Mapping Strategies in Experimental Models of Multiple Sclerosis

Bečanović, K., Jagodic, M., Wallström, E., & Olsson, T. P. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01462.x · Cited by 11

Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.

(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Constantinescu, C. S., Farooqi, N., O'Brien, K., & Gran, B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01302.x · Cited by 1,523

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

Wu, C., Yosef, N., Thalhamer, T., Zhu, C., Xiao, S., Kishi, Y., Regev, A., & Kuchroo, V. K. (2013) · Nature · doi:10.1038/nature11984 · Cited by 1,022

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

Kumar, D. K. V., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1059 · Cited by 971

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Du, C., Liu, C., Kang, J., Zhao, G., Ye, Z., Huang, S., Li, Z., Wu, Z., & Pei, G. (2009) · Nature Immunology · doi:10.1038/ni.1798 · Cited by 811