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Protocol for the MPTP mouse model of Parkinson's disease

Jackson-Lewis, Vernice, Przedborski, Serge·2007·Nature Protocols

DOI 10.1038/nprot.2006.342

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Parkinson's Disease
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Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
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“tetrahydropyridine (MPTP) is an illicit drug contaminant linked to human Parkinsonism cases,(115) which is commonly used as an animal model of PD.(116) After MPTP”
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Probiotics mixture increases butyrate, and subsequently rescues the nigral dopaminergic neurons from MPTP and rotenone-induced neurotoxicity
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Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins.
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“For the morphological studies, the mice (seven to eight per group) were anesthetized and perfused transcardially with saline at a flow rate of 10 mL / min for 3 min, followed by perfusion with a 4% paraformaldehyde solution for 8 min using a peristaltic pump, as provided [23].”
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BAX channel activity mediates lysosomal disruption linked to Parkinson disease
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Authors: Jackson-Lewis, V., & Przedborski, S.
Venue: Nature Protocols
Publisher: Springer Science and Business Media LLC
Published: 2007-01
Volume: 2
Issue: 1
Pages: 141-151
ISSN: 1750-2799 (ISSN-L)
1754-2189
DOI: 10.1038/nprot.2006.342
OpenAlex: W2022911097
Cited by: 1,111
References: 32
FWCI: 13.92
Type: journal article
Language: en
Open access: closed

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Protocol for the MPTP mouse model of Parkinson's disease

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