The DOI matches its Crossref record; 200 of the 200 references it cites were found in a registry or an index.
The circadian clock: pacemaker and tumour suppressor
Abstract
The circadian rhythms are daily oscillations in various biological processes that are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer in humans. One of the cellular processes that is regulated by circadian rhythm is cell proliferation, which often shows asynchrony between normal and malignant tissues. This asynchrony highlights the importance of the circadian clock in tumour suppression in vivo and is one of the theoretical foundations for cancer chronotherapy. Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets.
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“The circadian system and its prime marker, melatonin, are considered to have antitumor effects through multiple pathways, including antioxidant activity, anti-inflammatory effects, and immune enhancement.33-37”
From Total and Cause-Specific Mortality of U.S. Nurses Working Rotating Night Shifts (2015) · cites this paper as [35]
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Cites
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Molecular components of the mammalian circadian clock
Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,725
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The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
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Circadian Rhythms: Mechanisms and Therapeutic Implications
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Self-citation
Metadata
- Authors
- Fu, L., & Lee, C. C.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Lee, Cheng Chi
- Venue
- Nature reviews. Cancer
- Published
- 2003-05-01
- Volume
- 3
- Issue
- 5
- Pages
- 350-361
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1997364930
- Cited by
- 678
- References
- 200
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 16 · 2023: 25 · 2022: 25 · 2021: 21 · 2020: 26 · 2019: 33 · 2018: 42 · 2017: 36 · 2016: 29 · 2015: 37 · 2014: 34 · 2013: 44 · 2012: 42
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, circadian rhythm, tumor suppression, cell proliferation, cancer chronotherapy, circadian rhythm disruption, cancer, therapeutic target
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Eye Proteins, Humans, Neoplasms, Suprachiasmatic Nucleus, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-myc
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