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Contribution of platelets to tumour metastasis

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Gay, Laurie J., Felding-Habermann, Brunhilde·2011·Nature Reviews Cancer
DOI 10.1038/nrc3004
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Abstract

Extensive experimental evidence shows that platelets support tumour metastasis. The activation of platelets and the coagulation system have a crucial role in the progression of cancer. Within the circulatory system, platelets guard tumour cells from immune elimination and promote their arrest at the endothelium, supporting the establishment of secondary lesions. These contributions of platelets to tumour cell survival and spread suggest platelets as a new avenue for therapy.

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Cited by

See all 1,645

Metadata

Authors
Gay, L. J., & Felding-Habermann, B.
Venue
Nature Reviews Cancer
Publisher
Springer Science and Business Media LLC
Published
2011-01-24
Volume
11
Issue
2
Pages
123-134
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
DOI
10.1038/nrc3004
OpenAlex
W1968519475
Cited by
1,645
References
4
FWCI
8.41
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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