Cited by 1,294Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsCancer Immunotherapy and Biomarkers

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Translational biology of osteosarcoma

Kansara, Maya, Teng, Michele W., Smyth, Mark J., Thomas, David M.·2014·Nature Reviews Cancer

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Abstract

For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarcoma suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.

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Veratramine influences the proliferation of human osteosarcoma cells through modulating the PI3K/AKT signaling cascade
Zhou, X., Qu, X., Li, Z., Duan, Y., Zhu, Y., Wang, J., Han, X., Zhang, J., Luo, J., & Luo, X. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101630 · Cited by 3
Biomaterial-Mediated Drug Delivery in Primary and Metastatic Cancers of the Bone
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Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters
Gomez‐Brouchet, A., Illac, C., Ledoux, A., Fortin, P., Barros, S. D., Vabre, C., Despas, F., Peries, S., Casaroli, C., Bouvier, C., et al. (2022) · Cancers · doi:10.3390/cancers14030499 · Cited by 3
Development of a Simple Risk Model to Predict Mortality in Patients With Osteosarcoma of the Extremity
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Relaxin inhibits 177 Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway
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DPY30 promotes the growth and survival of osteosarcoma cell by regulating the PI3K/AKT signal pathway
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UBR5 Significantly Correlates with Osteosarcomas Prognosis and Immune Exhaustion Characteristic in the Tumor Microenvironment
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Development and validation of an oxidative stress‑related prognostic signature in osteosarcoma: A combination of molecular experiments and bioinformatics
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Bazedoxifene Suppresses the Growth of Osteosarcoma Cells by Inhibiting IL-6 and IL-11/GP130 Signaling Pathway
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Markers for bone sarcomas
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Retracted
WITHDRAWN: Photothermally reinforced chemodynamic therapy in the treatment of osteosarcoma by polydopamine-modified, copper peroxide loaded ZIF8 nanoparticles
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Retracted
CaP Scaffold Loaded with Multi-Functional Gel for Bone Repair after Resection of Osteosarcoma
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Research and progress of microRNA-136 in metastatic tumors
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KIAA1429‑mediated ZFPM2‑AS1 m6A modification promotes the proliferation, migration and invasion of osteosarcoma cells
Zhang, Y., Bao, Y., Zhai, H., Li, C., Shi, H., Gong, K., & Bao, X. (2025) · Oncology Letters · doi:10.3892/ol.2025.15199 · Cited by 2
A Glycerophospholipid Metabolism-Based Prognostic Model Guides Osteosarcoma Therapy
Wen, Y., Wang, D., Wang, H., Zhao, J., Li, Y., Zhang, J., & Chen, B. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102572 · Cited by 2
Basement membrane-associated gene P3H2 regulates osteosarcoma progression and epithelial-mesenchymal transition through AKT/mTOR signaling axis
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Identification of EEF1A2 as a potential therapy target of osteosarcoma using novel compound 8e
Xue, J., Li, M., Wang, Y., Sun, D., Hao, S., Liu, Z., Zhang, W., Li, L., Zhu, T., & Liu, S. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118355 · Cited by 2
Near-Infrared Light-Responsive Copper Selenide Nanoparticle-Loaded Calcium Silicate Cement Induces Immunogenic Cell Death in Osteosarcoma
Liu, R., Sun, R., Xue, Y., Zhou, Y., Zhan, L., Li, Y., Tian, Y., Wang, C., Feng, W., Chang, B., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s548764 · Cited by 2
Single-cell dissection of PTM-related networks reveals an immunosuppressed osteosarcoma ecosystem
Chen, J., Zhang, W., Yan, H., Chen, J., Liu, H., Zhou, X., Zhang, H., & Cheng, D. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1718941 · Cited by 2

Authors: Kansara, M., Teng, M. W., Smyth, M. J., & Thomas, D. M.
Affiliations: The University of Melbourne (AU)
The University of Queensland (AU)
Garvan Institute of Medical Research (AU)
Corresponding author: Thomas, David M.
ORCID: Kansara, Maya
Teng, Michele W.
Smyth, Mark J.
Thomas, David M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2014-10-16
Volume: 14
Issue: 11
Pages: 722-735
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3838
OpenAlex: W1980088710
Cited by: 1,294
References: 208
Citations by year: 2026: 66 · 2025: 130 · 2024: 134 · 2023: 155 · 2022: 161 · 2021: 173 · 2020: 152 · 2019: 86 · 2018: 66 · 2017: 74 · 2016: 65 · 2015: 29 · 2014: 2
FWCI: 9.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: osteosarcoma, bone biology, bone homeostasis, germline predisposition, cancer genomics, chromothripsis, kataegis, genomic instability, targeted therapy, mifamurtide, immune checkpoint inhibitors, adjuvant therapy, metastatic osteosarcoma, translational research
MeSH terms: Animals, Antineoplastic Agents, Bone Development, Humans, Osteosarcoma, Translational Research, Biomedical

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