Translational biology of osteosarcoma

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer

Brahmer, J. R., Tykodi, S. S., Chow, L. Q. M., Hwu, W.-J., Topalian, S. L., Hwu, P., Drake, C. G., Camacho, L. H., Kauh, J., Odunsi, K., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200694 · Cited by 7,945

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

Kantoff, P. W., Higano, C. S., Shore, N. D., Berger, E. R., Small, E. J., Penson, D. F., Redfern, C. H., Ferrari, A. C., Dreicer, R., Sims, R. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001294 · Cited by 5,572

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351

Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303

WHO Classification of Tumours of Soft Tissue and Bone: WHO Classification of Tumours, vol. 5

Fletcher, C. D. �., Bridge, J., Hogendoorn, P. C. W., & Mertens, F. (2013) · Cited by 3,072

WHO classification of tumours of soft tissue and bone

Fletcher, C. D. �. (2013) · Cited by 2,874

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Immunological aspects of cancer chemotherapy

Zitvogel, L., Apetoh, L., Ghiringhelli, F., & Kroemer, G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2216 · Cited by 1,712

RANK is essential for osteoclast and lymph node development.

Dougall, W. C., Glaccum, M., Charrier, K., Rohrbach, K., Brasel, K., De Smedt, T., Daro, E., Smith, J., Tometsko, M. E., Maliszewski, C. R., et al. (1999) · Genes & Development · doi:10.1101/gad.13.18.2412 · Cited by 1,478

Integrins identified as potential prognostic markers in osteosarcoma through multi-omics and multi-dataset analysis

Cui, L., Zhao, S., Teng, H., Yang, B., Liu, Q., & Qin, A. (2025) · npj Precision Oncology · doi:10.1038/s41698-024-00794-5 · Cited by 14

Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming

Zhao, T., He, L., Wong, L. P., Mei, S., Xia, J., Xu, Y., Vranken, J. G. V., Mazzola, M. C., Chen, L., Rhee, C., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.05.009 · Cited by 14

Antitumor Effect of miR-1294/Pyruvate Kinase M2 Signaling Cascade in Osteosarcoma Cells

Yuan, Q., Yu, H., Chen, J., Song, X., & Sun, L. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s232718 · Cited by 14

Thermogel Delivers Oxaliplatin and Alendronate in situ for Synergistic Osteosarcoma Therapy

Sun, Y., Li, K., Li, C., Zhang, Y., & Zhao, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.573962 · Cited by 15

von Willebrand factor promotes platelet-induced metastasis of osteosarcoma through activation of the VWF-GPIb axis

Wang, Q., Liu, W., Fan, J., Guo, J. J., Shen, F., Ma, Z., Ruan, C., Guo, L., Jiang, M., & Zhao, Y. (2020) · Journal of bone oncology · doi:10.1016/j.jbo.2020.100325 · Cited by 14

Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma

Zhang, J., Miao, X., Wu, T., Jia, J., & Cheng, X. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.751842 · Cited by 14

LIM Kinases in Osteosarcoma Development

Brion, R., Regnier, L., Mullard, M., Amiaud, J., Rédiní, F., & Verrecchia, F. (2021) · Cells · doi:10.3390/cells10123542 · Cited by 14

Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells

Veys, C., Jammes, M., Rédiní, F., Poulain, L., Denoyelle, C., Legendre, F., & Galéra, P. (2022) · Pharmaceuticals · doi:10.3390/ph15030362 · Cited by 14

Identification of a novel gene signature with regard to ferroptosis, prognosis prediction, and immune microenvironment in osteosarcoma

Zheng, D., Xia, K., Wei, Z., Wei, Z., & Guo, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.944978 · Cited by 14

Hierarchically Structured Hydroxyapatite Particles Facilitate the Enhanced Integration and Selective Anti‐Tumor Effects of Amphiphilic Prodrug for Osteosarcoma Therapy

Xu, D. Y., Wan, Y., Xie, Z., Du, C., & Wang, Y. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202668 · Cited by 14

PF-06409577 Activates AMPK Signaling and Inhibits Osteosarcoma Cell Growth

Zhu, Y.-R., Zhang, X.-Y., Wu, Q., Yu, C.-J., Liu, Y.-Y., & Zhang, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.659181 · Cited by 14

High SENP3 Expression Promotes Cell Migration, Invasion, and Proliferation by Modulating DNA Methylation of E-Cadherin in Osteosarcoma

Yang, P., Liu, Y., Qi, Y. C., & Lian, Z. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820956988 · Cited by 13

Anti-proliferative, pro-apototic and anti-migratory properties of HDAC inhibitor PXD-101 on osteosarcoma cell lines

Rossi, M., Martino, V. D., Giuseppe, L. D., Battafarano, G., Gregorio, J. D., Terreri, S., Marampon, F., Minisola, S., & Fattore, A. D. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109489 · Cited by 13

Cancer-associated fibroblast infiltration in osteosarcoma: the discrepancy in subtypes pathways and immunosuppression

Zhihao, Z., Cheng, J., Xiaoshuang, Z., Ma, Y., Wu, T., Yang, Y., Zhou, Y., Jie, Z., Tao, Z., Hu, X., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1136960 · Cited by 14

Developing Single-Atomic Manganese Nanozymes for Synergistic Mild Photothermal/Multienzymatic Therapy

Wang, C.-S., Xue, H.-B., Zhuang, L., Sun, H.-P., Zheng, H. S., Wang, S., He, S., & Luo, X. (2023) · ACS Omega · doi:10.1021/acsomega.3c07714 · Cited by 13

WWOX promotes osteosarcoma development via upregulation of Myc

Akkawi, R., Hidmi, O., Haj-Yahia, A., Monin, J., Diment, J., Drier, Y., Stein, G. S., & Aqeilan, R. I. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06378-8 · Cited by 13

METTL3 promotes the progression of osteosarcoma through the N6-methyladenosine modification of MCAM via IGF2BP1

Song, D., Wang, Q., Yan, Z., Su, M., Zhang, H., Shi, L., Fan, Y., Zhang, Q., Yang, H., Zhang, D., et al. (2024) · Biology Direct · doi:10.1186/s13062-024-00486-x · Cited by 13

Apoptotic Induction by Biosynthesized Gold Nanoparticles Using Phormidesmis communis Strain AB_11_10 against Osteosarcoma Cancer

Hamida, R. S., AlMotwaa, S. M., Al‐Otaibi, W. A., Alqhtani, H. A., Ali, M. A., & Bin-Meferij, M. M. (2024) · Biomedicines · doi:10.3390/biomedicines12071570 · Cited by 13

Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies

Shen, J., Lai, Y., Wu, Y., Lin, X. H., Zhang, C., & Liu, H. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2024.0231 · Cited by 13

Unraveling IFI44L’s biofunction in human disease

Du, J., Luo, H., Ye, S., Zhang, H., Zheng, Z., & Liu, K. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1436576 · Cited by 13

Clinical and Pathological Profile of Children and Adolescents with Osteosarcoma

Ivan, A., Cojocaru, E., Sîrbu, P. D., Namat, D. A., Tîrnovanu, Ș.-D., Butnariu, L. I., Bernic, J., Bernic, V., & Țarcă, E. (2025) · Diagnostics · doi:10.3390/diagnostics15030266 · Cited by 13

Three-dimensional preclinical models for Osteosarcoma: Advances and translational prospects

Puce, A., Ferraresi, V., Biagini, R., Soddu, S., & Loria, R. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118471 · Cited by 14

Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors

Lee, J. W., Kim, N. K. D., Lee, S. H., Cho, H. W., Ma, Y., Ju, H. Y., Yoo, K. H., Sung, K. W., Koo, H. H., & Park, W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224227 · Cited by 13

What Factors Define Limb Salvage or Amputation Surgery in Osteosarcoma of the Upper Extremities?

Huayllani, M. T., Restrepo, D. J., Boczar, D., Sisti, A., Spaulding, A., Parker, A. S., Manrique, O. J., Lu, X., Wilke, B. K., & Forte, A. J. (2019) · Anticancer Research · doi:10.21873/anticanres.13896 · Cited by 13

KIF21B Expression in Osteosarcoma and Its Regulatory Effect on Osteosarcoma Cell Proliferation and Apoptosis Through the PI3K/AKT Pathway

Ni, S., Li, J., Qiu, S., Xie, Y., Gong, K., & Duan, Y. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.606765 · Cited by 13

New drug candidates for osteosarcoma: Drug repurposing based on gene expression signature

Andrade, R. C., Boroni, M., Amazonas, M. K., & Vargas, F. R. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104470 · Cited by 13

Review of LINC00707: A Novel LncRNA and Promising Biomarker for Human Diseases

Yao, Q., Li, Z., & Chen, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.813963 · Cited by 13

Film-facilitated formation of ferrocenecarboxylic acid-embedded metal-organic framework nanoparticles for sonodynamic osteosarcoma treatment

Deng, X., Guo, Y., Zhang, X., Wu, W., Wu, Y., Jing, D., Wang, D., Shao, Z., & Zhao, Y. (2022) · Materials Today Chemistry · doi:10.1016/j.mtchem.2022.100842 · Cited by 13

Exploration and Validation of a Novel Inflammatory Response-Associated Gene Signature to Predict Osteosarcoma Prognosis and Immune Infiltration

Fu, Y., He, G., Liu, Z., Wang, J., Zhang, Z., Bao, Q., Wen, J., Jin, Z., & Zhang, W. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s340477 · Cited by 13

A ubiquitin-related gene signature for predicting prognosis and constructing molecular subtypes in osteosarcoma

Wei, N., Chao-yang, G., Zhou, W., Ze-yuan, L., Shi, Y., Shun-bai, Z., Kai, Z., Yan-chao, M., & Zhang, H.-H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.904448 · Cited by 13

Enhancement of T Cell Infiltration via Tumor-Targeted Th9 Cell Delivery Improves the Efficacy of Antitumor Immunotherapy of Solid Tumors

Chen, T., Xue, Y., Wang, S., Lu, J., Zhou, H., Zhang, W., Zhou, Z., Li, B., Li, Y., Wang, Z., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.022 · Cited by 13

CircNRIP1: An emerging star in multiple cancers

Du, Z. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154281 · Cited by 13

Analysis of intercellular communication in the osteosarcoma microenvironment based on single cell sequencing data

Chen, F., Liu, J., Yang, T., Sun, J., He, X., Fu, X., Qiao, S., An, J., & Yang, J. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100493 · Cited by 14

A-to-I RNA editing shows dramatic up-regulation in osteosarcoma and broadly regulates tumor-related genes by altering microRNA target regions

Ge, F., Cao, X., & Jiang, Y. (2023) · Journal of Applied Genetics · doi:10.1007/s13353-023-00777-5 · Cited by 13

Multifunctional bioactive glasses with spontaneous degradation for simultaneous osteosarcoma therapy and bone regeneration

Gu, J., Liu, X., Cui, P., & Yi, X. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213626 · Cited by 13

microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation

Li, Z., Zhu, Y.-R., Zhou, X., Zhuo, B., & Wang, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15477 · Cited by 13

Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway

Liu, B., Xu, L., Dai, E., Tian, J., & Li, J. (2018) · Bioscience Reports · doi:10.1042/bsr20181501 · Cited by 13

Novel Expression of EGFL7 in Osteosarcoma and Sensitivity to Cisplatin

Liu, Q., He, H., Yuan, Y., Zeng, H., Wang, Z., & Luo, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00074 · Cited by 13

microRNA-524-5p inhibits proliferation and induces cell cycle arrest of osteosarcoma cells via targeting CDK6

Chen, H., Cheng, C., & Gao, S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.092 · Cited by 13

LncRNA CCAL Promotes Angiogenesis Through Regulating the MiR-29b/ANGPTL4 Axis in Osteosarcoma

Chen, S., Yang, M., & Chang, S. (2020) · Cancer Management and Research · doi:10.2147/cmar.s272230 · Cited by 13

Identification of two immune subtypes in osteosarcoma based on immune gene sets

Yang, M., Cao, Y., Wang, Z., Zhang, T., Hua, Y., & Cai, Z. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107799 · Cited by 13

Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway

Wang, S., Wang, Y., Huang, Z., Wei, H., Wang, X., Shen, R., Lan, W., Zhong, G., & Lin, J. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmab146 · Cited by 13

Molecular mechanisms underlying the inhibitory effects of bovine lactoferrin on osteosarcoma

Chea, C., Haing, S., Miyauchi, M., Shrestha, M., Imanaka, H., & Takata, T. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.204 · Cited by 13

Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes

Zhao, Q., Hu, W., Xia, Y., Dai, S., Wu, X., Chen, J., Yuan, X., Zhong, T., Xi, X., & Wang, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-00179-z · Cited by 12

Studying the mechanism underlying lipid metabolism in osteosarcoma based on transcriptomic RNA sequencing and single‐cell data

Li, Z., Jin, C., Lu, X., Zhang, Y., Zhang, Y., Wen, J., Liu, Y., Liu, X., & Li, J. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3491 · Cited by 12

Circular RNAs in osteosarcoma: An update of recent studies (Review)

Zeng, L., Liu, L., Ni, W.-J., Xie, F., & Leng, X.-M. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5571 · Cited by 12

Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis

Liu, F., Zhang, T., Yang, Y., Wang, K., Wei, J., Shi, J., Zhang, D., Sheng, X., Zhang, Y., Zhou, J., et al. (2025) · BMC Cancer · doi:10.1186/s12885-025-13714-y · Cited by 13

Novel Germline PTEN Mutation Associated with Cowden Syndrome and Osteosarcoma

López, C., Abuel‐Haija, M., Peña, L., & Coppola, D. (2018) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20069 · Cited by 12

Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway

Xu, Y., Teng, Y., Ni, H., Zheng, R., Huang, K., Huang, Y., Gao, J., Qiao, D., Shen, S., & Ma, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.642605 · Cited by 12

Establishment of an Autophagy‐Related Clinical Prognosis Model for Predicting the Overall Survival of Osteosarcoma

Li, J., Tang, X., Du, Y., Dong, J., Zhao, Z., Hu, H., Song, T., Guo, J., Wang, Y., Xu, T., et al. (2021) · BioMed Research International · doi:10.1155/2021/5428425 · Cited by 12

Hsa-miR-557 Inhibits Osteosarcoma Growth Through Targeting KRAS

Qiao, Z., Li, J., Kou, H., Chen, X., Bao, D., Shang, G., Chen, S., Ji, Y., Cheng, T., Wang, Y., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.789823 · Cited by 12

Construction and validation of a novel apoptosis-associated prognostic signature related to osteosarcoma metastasis and immune infiltration

Fu, Y., Jin, Z., Shen, Y., Zhang, Z., Li, M., Liu, Z., He, G., Wu, J., Wen, J., Bao, Q., et al. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101452 · Cited by 12

Anti-GD2 antibody for radiopharmaceutical imaging of osteosarcoma

Fu, Y., Yu, J., Liatsou, I., Du, Y., Josefsson, A., Nedrow, J. R., Rindt, H., Bryan, J. N., Kraitchman, D. L., & Sgouros, G. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05888-5 · Cited by 12

Heparin and Heparin-Based Drug Delivery Systems: Pleiotropic Molecular Effects at Multiple Drug Resistance of Osteosarcoma and Immune Cells

Тодосенко, Н. М., Yurova, K. A., Хазиахматова, О. Г., Malashchenko, V. V., Хлусов, И. А., & Litvinova, L. S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102181 · Cited by 12

Identification of novel prognostic biomarkers for osteosarcoma: a bioinformatics analysis of differentially expressed genes in the mesenchymal stem cells from single-cell sequencing data set

Jiang, H., Du, H., Liu, Y., Tian, X., Xia, J., & Yang, S. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-2370 · Cited by 12

A mitochondria-related signature for predicting immune microenvironment and therapeutic response in osteosarcoma

Zhang, L., Wu, S. J., Huang, J., Shi, Y., Yin, Y., & Cao, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1085065 · Cited by 12

CD44 and HAP‐Conjugated hADSCs as Living Materials for Targeted Tumor Therapy and Bone Regeneration

Xia, H., Hao, M., Li, K., Chen, X., Yu, L., Qiu, J., Zhang, H., Li, H., Sang, Y., & Liu, H. (2023) · Advanced Science · doi:10.1002/advs.202206393 · Cited by 12

Shedding Light on Osteosarcoma Cell Differentiation: Impact on Biomineralization and Mitochondria Morphology

Rossi, F., Picone, G., Cappadone, C., Sorrentino, A., Columbaro, M., Farruggia, G., Catelli, E., Sciutto, G., Prati, S., Oliete, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108559 · Cited by 12

Integrated analysis of single-cell and bulk RNA sequencing data reveals an immunostimulatory microenvironment in tumor thrombus of osteosarcoma

Ji, T., Shi, Q., Mei, S., Xu, J., Liang, H., Xie, L., Ren, T., Sun, K., Li, D., Tang, X., et al. (2023) · Oncogenesis · doi:10.1038/s41389-023-00474-2 · Cited by 12

RUNX Family as a Promising Biomarker and a Therapeutic Target in Bone Cancers: A Review on Its Molecular Mechanism(s) behind Tumorigenesis

Vimalraj, S., & Sekaran, S. (2023) · Cancers · doi:10.3390/cancers15123247 · Cited by 12

Beauvericin suppresses the proliferation and pulmonary metastasis of osteosarcoma by selectively inhibiting TGFBR2 pathway

Ye, G., Jiao, Y., Deng, L., Cheng, M.-J., Wang, S., Zhang, J., Ouyang, J., Li, Y. H., He, Y., Tu, Z., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.86214 · Cited by 12

Potential targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy

Zhu, J., Fan, J., Xia, Y., Wang, H., Li, Y., Feng, Z., & Fu, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1271321 · Cited by 13

Osteosarcoma in a Patient With Pseudohypoparathyroidism Type 1b Due to Paternal Uniparental Disomy of Chromosome 20q

Park, H., Kim, C. G., Hong, N., Lee, S. J., Seo, D. H., & Rhee, Y. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3043 · Cited by 12

Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70

Zhang, F., Zhu, Y., Fan, G., & Hu, S. (2018) · Oncology Letters · doi:10.3892/ol.2018.9322 · Cited by 12

A Retrospective Clinicopathological Study of Osteosarcoma Patients with Metachronous Metastatic Relapse

Bao, J., Zeng, J., Song, C., Yu, H., Shi, Q., Mai, W., & Qu, G. (2019) · Journal of Cancer · doi:10.7150/jca.30750 · Cited by 12

Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases

Li, G., Zhang, T., Huang, K., Zhu, Y., Xu, K., Gu, J., Huang, S., Gu, C., Zhan, R., & Shen, J. G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111572 · Cited by 12

Fraxinellone Has Anticancer Activity by Inducing Osteosarcoma Cell Apoptosis via Promoting Excessive Autophagy Flux

He, B., Zhang, W., & He, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653212 · Cited by 12

Whole-exome sequencing in osteosarcoma with distinct prognosis reveals disparate genetic heterogeneity

Liu, W., Wang, R., Zhang, Y., Wang, H., Huang, Z., Jin, T., Yang, Y., Sun, Y., Cao, S., & Niu, X. (2021) · Cancer Genetics · doi:10.1016/j.cancergen.2021.05.013 · Cited by 12

MTHFR Polymorphism Is Associated With Severe Methotrexate-Induced Toxicity in Osteosarcoma Treatment

Zhang, W., Liu, Z., Yang, Z., Feng, C., Zhou, X., Tu, C., & Li, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.781386 · Cited by 12

Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo

Watanabe, K., Yui, Y., Sasagawa, S., Suzuki, K., Kanamori, M., Yasuda, T., & Kimura, T. (2019) · Oncotarget · doi:10.18632/oncotarget.26536 · Cited by 12

By using machine learning and in vitro testing, SERPINH1 functions as a novel tumorigenic and immunogenic gene and predicts immunotherapy response in osteosarcoma

Xia, G., Wu, S. J., Luo, K., & Cui, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1180191 · Cited by 11

Self-assembled chitosan-sodium usnate drug delivery nanosystems: Synthesis, characterization, stability studies, in vitro cytotoxicity and in vivo biocompatibility against 143 B cells

Brugnoli, B., Mariano, A., Simonis, B., Bombelli, C., Sennato, S., Piozzi, A., Taresco, V., Chauhan, V. M., Howdle, S. M., d’Abusco, A. S., et al. (2023) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2023.100373 · Cited by 11

Single-cell and bulk RNA sequencing reveals Anoikis related genes to guide prognosis and immunotherapy in osteosarcoma

Zhong, C., Yang, D., Zhong, L., Xie, W., Sun, G., Jin, D., & Li, Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-47367-3 · Cited by 11

Metabolic Landscape of Osteosarcoma: Reprogramming of Lactic Acid Metabolism and Metabolic Communication

Wang, L., Dou, X., Xie, L., Zhou, X., Liu, Y., Liu, J., & Liu, X. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2902083 · Cited by 11

EphA2-specific microvesicles derived from tumor cells facilitate the targeted delivery of chemotherapeutic drugs for osteosarcoma therapy

Wang, Z., He, Z., Wan, J., Chen, A., Cheng, P., & Zhu, W. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02372-0 · Cited by 12

Nanoparticles-encapsulated doxorubicin alleviates drug resistance of osteosarcoma via inducing ferroptosis

Tian, X., Zhang, Y., Zhang, M., Liu, G., Hao, Y., & Liu, W. (2024) · Nanotoxicology · doi:10.1080/17435390.2024.2369602 · Cited by 11

Implant derived high local concentration of magnesium inhibits tumorigenicity of osteosarcoma

Gong, G., Huang, H., Tong, Z., Zheng, Y., Bian, D., & Zhang, Y. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123263 · Cited by 11

Chromoanagenesis in Osteosarcoma

Li, G., Wu, N., Ghabrial, J., Stinnett, V., Klausner, M., Morsberger, L. A., Long, P., Baraban, E. G., Gross, J. M., & Zou, Y. S. (2025) · Biomolecules · doi:10.3390/biom15060833 · Cited by 11

Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment

Song, Z., Lu, S., Yang, Y., Chen, Z., Chen, Y., Cao, J., Zhang, Z., Ge, J., Yang, H., & Cheng, L. (2025) · National Science Review · doi:10.1093/nsr/nwaf365 · Cited by 12

Restoration of microRNA‑130b expression suppresses osteosarcoma cell malignant behavior in�vitro

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Baldauf, C., Jeschke, A., Kanbach, V., Catalá-Lehnen, P., Baumhoer, D., Gerull, H., Buhs, S., Amling, M., Nollau, P., Harroch, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137745 · Cited by 11

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Cheng, H., Gong, Z., Hu, H., Zhang, M., Liu, X., Xu, Y., Zeng, Y., Chen, J., & Zhu, Z. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb02865a · Cited by 11

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Chen, C., Xie, L., Ren, T., Huang, Y., Xu, J. H., & Guo, W. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.024 · Cited by 587

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