Cited by 1,294Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsCancer Immunotherapy and Biomarkers

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Translational biology of osteosarcoma

Kansara, Maya, Teng, Michele W., Smyth, Mark J., Thomas, David M.·2014·Nature Reviews Cancer

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Abstract

For the past 30 years, improvements in the survival of patients with osteosarcoma have been mostly incremental. Despite evidence of genomic instability and a high frequency of chromothripsis and kataegis, osteosarcomas carry few recurrent targetable mutations, and trials of targeted agents have been generally disappointing. Bone has a highly specialized immune environment and many immune signalling pathways are important in bone homeostasis. The success of the innate immune stimulant mifamurtide in the adjuvant treatment of non-metastatic osteosarcoma suggests that newer immune-based treatments, such as immune checkpoint inhibitors, may substantially improve disease outcome.

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Authors: Kansara, M., Teng, M. W., Smyth, M. J., & Thomas, D. M.
Affiliations: The University of Melbourne (AU)
The University of Queensland (AU)
Garvan Institute of Medical Research (AU)
Corresponding author: Thomas, David M.
ORCID: Kansara, Maya
Teng, Michele W.
Smyth, Mark J.
Thomas, David M.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2014-10-16
Volume: 14
Issue: 11
Pages: 722-735
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3838
OpenAlex: W1980088710
Cited by: 1,294
References: 208
Citations by year: 2026: 66 · 2025: 130 · 2024: 134 · 2023: 155 · 2022: 161 · 2021: 173 · 2020: 152 · 2019: 86 · 2018: 66 · 2017: 74 · 2016: 65 · 2015: 29 · 2014: 2
FWCI: 9.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: osteosarcoma, bone biology, bone homeostasis, germline predisposition, cancer genomics, chromothripsis, kataegis, genomic instability, targeted therapy, mifamurtide, immune checkpoint inhibitors, adjuvant therapy, metastatic osteosarcoma, translational research
MeSH terms: Animals, Antineoplastic Agents, Bone Development, Humans, Osteosarcoma, Translational Research, Biomedical

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