Tumor microenvironment: The role of the tumor stroma in cancer
Abstract
The tumor microenvironment, composed of non‐cancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining location of metastatic disease, and impacting the outcome of therapy. While the stromal cells are not malignant per se, their role in supporting cancer growth is so vital to the survival of the tumor that they have become an attractive target for chemotherapeutic agents. In this review, we will discuss the various cellular and molecular components of the stromal environment, their effects on cancer cell dynamics, and the rationale and implications of targeting this environment for control of cancer. Additionally, we will emphasize the role of the bone marrow‐derived cell in providing cells for the stroma. J. Cell. Biochem. 101: 805–815, 2007. © 2007 Wiley‐Liss, Inc.
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Stromal cells of the tumor microenvironment play a major part in cancer, and their communication with cancer cells is associated with regulation of tumor growth, metastasis, and treatment outcome.
“The stromal cells of the tumor microenvironment play a major part in cancer, and their communication with cancer cells has been associated with the regulation of tumor growth, metastasis, and even treatment outcome, making them attractive targets for cancer treatment. 43”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [43]
Cites
1 retracted
Spontaneous Human Adult Stem Cell Transformation
Rubio, D., Garcı́a-Castro, J., Martín, M. C., de la Fuente, R., Cigudosa, J. C., Lloyd, A. C., & Bernad, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4194 · Cited by 1,030 · see citing works
RetractedHow Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959 · see citing works
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288 · see citing works
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
Coussens, L. M., Fingleton, B., & Matrisian, L. M. (2002) · Science · doi:10.1126/science.1067100 · Cited by 2,761 · see citing works
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600 · see citing works
Takahashi, T., Kalka, C., Masuda, H., Chen, D., Silver, M., Kearney, M., Magner, M., Isner, J. M., & Asahara, T. (1999) · Nature Medicine · doi:10.1038/7434 · Cited by 2,421 · see citing works
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809 · see citing works
VEGF as a Key Mediator of Angiogenesis in Cancer
Carmeliet, P. (2005) · Oncology · doi:10.1159/000088478 · Cited by 1,776 · see citing works
Metastatic potential correlates with enzymatic degradation of basement membrane collagen
Liotta, L. A., Tryggvason, K., Garbisa, S., Hart, I. R., Foltz, C. M., & Shafie, S. M. (1980) · Nature · doi:10.1038/284067a0 · Cited by 1,768 · see citing works
Presta, L. G., Chen, H., O'Connor, S. J., Chisholm, V., Meng, Y. G., KRUMMEN, L. A., Winkler, M., & Ferrara, N. (1997) · PubMed · Cited by 1,602 · see citing works
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,600 · see citing works
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589 · see citing works
Thun, M. J., Henley, S. J., & Patrono, C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.4.252 · Cited by 1,430 · see citing works
A Randomized Trial of Aspirin to Prevent Colorectal Adenomas
Baron, J. A., Cole, B. F., Sandler, R. S., Haile, R. W., Ahnen, D. J., Bresalier, R. S., McKeown‐Eyssen, G., Summers, R. W., Rothstein, R. I., Burke, C. A., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021735 · Cited by 1,414 · see citing works
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works
MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306 · see citing works
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
Radisky, D. C., Levy, D. D., Littlepage, L. E., Liu, H., Nelson, C. M., Fata, J. E., Leake, D., Godden, E. L., Albertson, D. G., Angela Nieto, M., et al. (2005) · Nature · doi:10.1038/nature03688 · Cited by 1,284 · see citing works
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
Burger, J. A., & Kipps, T. J. (2005) · Blood · doi:10.1182/blood-2005-08-3182 · Cited by 1,172 · see citing works
Gastric Cancer Originating from Bone Marrow-Derived Cells
Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J. E., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., & Wang, T. C. (2004) · Science · doi:10.1126/science.1099513 · Cited by 1,167 · see citing works
Self-citationYamaguchi, J.-I., Kusano, K. F., Masuo, O., Kawamoto, A., Silver, M., Murasawa, S., Bosch‐Marcé, M., Masuda, H., Losordo, D. W., Isner, J. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000055313.77510.22 · Cited by 1,149 · see citing works
Yang, L., DeBusk, L. M., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., Matrisian, L. M., Carbone, D. P., & Lin, P. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.031 · Cited by 1,140 · see citing works
Sandler, R. S., Halabi, S., Baron, J. A., Budinger, S., Paskett, E. D., Keresztes, R. S., Petrelli, N. J., Pipas, J. M., Karp, D. D., Loprinzi, C. L., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021633 · Cited by 1,133 · see citing works
Boire, A. A., Covic, L., Agarwal, A., Jacques, S. L., Sherifi, S., & Kuliopulos, A. (2005) · Cell · doi:10.1016/j.cell.2004.12.018 · Cited by 841 · see citing works
(2002) · PubMed · Cited by 840 · see citing works
Reconstruction of functionally normal and malignant human breast tissues in mice
Kuperwasser, C., Chavarria, T. E., Wu, M., Magrane, G., Gray, J. W., Carey, L., Richardson, A. L., & Weinberg, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401064101 · Cited by 807 · see citing works
Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study
Schreinemachers, D. M., & Everson, R. B. (1994) · Epidemiology · doi:10.1097/00001648-199403000-00003 · Cited by 738 · see citing works
Hattori, K., Dias, S., Heissig, B., Hackett, N. R., Lyden, D. C., Tateno, M., Hicklin, D. J., Zhu, Z., Witte, L., Crystal, R. G., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1005 · Cited by 685 · see citing works
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.
Feldser, D. M., Agani, F. H., Iyer, N. V., Pak, B. J., Ferreira, G., & Semenza, G. L. (1999) · PubMed · Cited by 638 · see citing works
Iwaguro, H., Yamaguchi, J.-I., Kalka, C., Murasawa, S., Masuda, H., Hayashi, S.-I., Silver, M., Li, T., Isner, J. M., & Asahara, T. (2002) · Circulation · doi:10.1161/hc0602.103673 · Cited by 587 · see citing works
Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530 · see citing works
Rønnov‐Jessen, L., & PETERSEN, O. W. (1993) · PubMed · Cited by 514 · see citing works
Contribution of bone marrow–derived endothelial cells to human tumor vasculature
Peters, B. A., Diaz, L. A., Polyák, K., Meszler, L., Romans, K., Guinan, E. C., Antin, J. H., Myerson, D., Hamilton, S. R., Vogelstein, B., et al. (2005) · Nature Medicine · doi:10.1038/nm1200 · Cited by 481 · see citing works
黒瀬, 圭., Gilley, K., Matsumoto, S., Watson, P. H., Zhou, X.-P., & Eng, C. (2002) · Nature Genetics · doi:10.1038/ng1013 · Cited by 418 · see citing works
Adult human mesenchymal stem cell as a target for neoplastic transformation
Serakinci, N., Guldberg, P., Burns, J. S., Abdallah, B., Schrødder, H., Jensen, T., & Kassem, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207651 · Cited by 350 · see citing works
Derangement of immune responses by myeloid suppressor cells
Serafini, P., Santo, C. D., Marigo, I., Cingarlini, S., Dolcetti, L., Gallina, G., Zanovello, P., & Bronte, V. (2003) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-003-0443-2 · Cited by 335 · see citing works
Epithelial to Mesenchymal Transition in Human Breast Cancer Can Provide a Nonmalignant Stroma
PETERSEN, O. W., Nielsen, H. L., Guðjónsson, Þ., Villadsen, R., Rank, F. E., Niebuhr, E., Bissell, M. J., & Rønnov‐Jessen, L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63834-5 · Cited by 305 · see citing works
Dvorak, H. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01361.x · Cited by 296 · see citing works
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-β
Stuelten, C. H., Byfield, S. D., Arany, P. R., Karpova, T., Stetler‐Stevenson, W. G., & Roberts, A. B. (2005) · Journal of Cell Science · doi:10.1242/jcs.02334 · Cited by 236 · see citing works
Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer
Overall, C. M., & Dean, R. A. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7890-0 · Cited by 218 · see citing works
Non-steroidal anti-inflammatory drugs and bladder cancer prevention
Castelao, J. E., Yuan, J.-M., Gago-Domínguez, M., et al. (2000) · British Journal of Cancer · doi:10.1054/bjoc.1999.1106 · Cited by 214 · see citing works
Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)
Nishi, H., Nakada, T., Kyo, S., Inoue, M., Shay, J. W., & Isaka, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.6076-6083.2004 · Cited by 213 · see citing works
The fibroblast: Sentinel cell and local immune modulator in tumor tissue
Silzle, T., Randolph, G. J., Kreutz, M. P., & Kunz‐Schughart, L. A. (2003) · International Journal of Cancer · doi:10.1002/ijc.11542 · Cited by 185 · see citing works
Macrophage Elastase (Matrix Metalloproteinase-12) Suppresses Growth of Lung Metastases
Houghton, A. M., Grisolano, J. L., Baumann, M. L., Kobayashi, D. K., Hautamaki, R. D., Nehring, L. C., Cornelius, L. A., & Shapiro, S. D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-04-0297 · Cited by 178 · see citing works
Bindra, R. S., & Glazer, P. M. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.03.013 · Cited by 168 · see citing works
Jodele, S., Chantrain, C. F., Blavier, L., Lutzko, C., Crooks, G. M., Shimada, H., Coussens, L. M., & DeClerck, Y. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3770 · Cited by 157 · see citing works
Okuyama, H., Krishnamachary, B., Zhou, Y. F., Nagasawa, H., Bosch‐Marcé, M., & Semenza, G. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602003200 · Cited by 151 · see citing works
MT1-MMP: Universal or particular player in angiogenesis?
Genı́s, L., Gálvez, B. G., Gonzalo, P., & Arroyo, A. G. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-7891-z · Cited by 141 · see citing works
Role of fibroblast activation in inducing interstitial fibrosis.
Zeisberg, M., Strutz, F. M., & Muller, G. A. (2001) · PubMed · Cited by 136 · see citing works
Sangaletti, S., Stoppacciaro, A., Guiducci, C., Torrisi, M. R., & Colombo, M. P. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030202 · Cited by 132 · see citing works
Fibronectin fragments and their role in inflammatory arthritis
Barilla, M.-L., & Carsons, S. E. (2000) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(00)80012-8 · Cited by 116 · see citing works
Cellular activation through the ligation of intercellular adhesion molecule-1
Clayton, A., Evans, R. A., Pettit, E. J., Hallett, M. B., Williams, J. D., & Steadman, R. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.4.443 · Cited by 114 · see citing works
The role of heparan sulphate proteoglycans in angiogenesis
Stringer, S. E. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340451 · Cited by 99 · see citing works
Skin Carcinoma Arising From Donor Cells in a Kidney Transplant Recipient
Aractingi, S., Kanitakis, J., Euvrard, S., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2783 · Cited by 93 · see citing works
Tuhkanen, H. E., Anttila, M., Kosma, V., Ylä‐Herttuala, S., Heinonen, S. T., Kuronen, A., Juhola, M. T., Tammi, R., Tammi, M., & Mannermaa, A. (2003) · International Journal of Cancer · doi:10.1002/ijc.11733 · Cited by 82 · see citing works
Occurrence of a fetal fibroblast phenotype in familial breast cancer
Schor, S. L., Haggie, J. A., Durning, P. E., et al. (1986) · International Journal of Cancer · doi:10.1002/ijc.2910370606 · Cited by 73 · see citing works
New non-angiogenesis dependent pathways for tumour growth
Ribatti, D., Vacca, A., & Dammacco, F. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00267-3 · Cited by 58 · see citing works
Matrix metalloproteinases target protease-activated receptors on the tumor cell surface
Pei, D. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.011 · Cited by 55 · see citing works
Age and Sex Variation in Lipid Composition of Human Fingernail Plates1
Helmdach, M., Thielitz, A., Röpke, E.-M., & Gollnick, H. P. M. (2000) · Skin Pharmacology and Physiology · doi:10.1159/000029915 · Cited by 53 · see citing works
Involvement of Mast Cells in Angiogenesis and Chronic Inflammation
Crivellato, E., & Ribatti, D. (2005) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010053622876 · Cited by 35 · see citing works
Role of hematopoietic lineage cells as accessory components in blood vessel formation
Takakura, N. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00223.x · Cited by 33 · see citing works
Cross-talk Between Hematopoiesis and Angiogenesis Signaling Pathways
Ribatti, D., Vacca, A., Nico, B., et al. (2002) · Current Molecular Medicine · doi:10.2174/1566524023362195 · Cited by 33 · see citing works
Genetic Predisposition to Cancer in Man: In Vitro Studies
Kopelovich, L. (1982) · International review of cytology · doi:10.1016/s0074-7696(08)62464-x · Cited by 31 · see citing works
Guo, L., Luo, X., Xie, H., et al. (2006) · Calcified Tissue International · doi:10.1007/s00223-005-0092-x · Cited by 25 · see citing works
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Edmondson, R., Broglie, J. J., Adcock, A. F., & Yang, L. (2014) · ASSAY and Drug Development Technologies · doi:10.1089/adt.2014.573 · Cited by 2,515 · see citing works
Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290 · see citing works
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Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144 · see citing works
Hu, J. L., Wang, W., Lan, X. L., Zeng, Z. C., Liang, Y. S., Yan, Y. R., Song, F. Y., Wang, F. F., Zhu, X. H., Liao, W. J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1019-x · Cited by 773 · see citing works
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Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757 · see citing works
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Shiga, K., Hara, M., Nagasaki, T., Sato, T., Takahashi, H., & Takeyama, H. (2015) · Cancers · doi:10.3390/cancers7040902 · Cited by 774 · see citing works
Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., Wood, O., Machado, M., Lopez, M.-A., Ganesan, A.-P., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3158 · Cited by 411 · see citing works
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Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251 · see citing works
Fitzgerald, D. P., Palmieri, D., Hua, E., Hargrave, E., Herring, J. M., Qian, Y., Vega-Valle, E., Weil, R. J., Stark, A. M., Vortmeyer, A. O., et al. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9193-z · Cited by 218 · see citing works
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Yang, Y., Yang, Y., Yang, J., Zhao, X., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00758 · Cited by 218 · see citing works
Tariq, M., Zhang, J., Liang, G., Ding, L., He, Q., & Yang, B. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25895 · Cited by 178 · see citing works
Elgundi, Z., Papanicolaou, M., Major, G., Cox, T. R., Melrose, J., Whitelock, J. M., & Farrugia, B. L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01482 · Cited by 176 · see citing works
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Barker, H. E., Bird, D., Lang, G., & Erler, J. T. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0033-t · Cited by 119 · see citing works
Sullivan, R., Maresh, G., Zhang, X., Salomon, C., Hooper, J., Margolin, D., & Li, L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00194 · Cited by 112 · see citing works
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Nie, D. (2010) · Frontiers in Bioscience · doi:10.2741/s56 · Cited by 19 · see citing works
- Authors
- Li, H., Fan, X., & Houghton, J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Houghton, JeanMarie
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2007-01-16
- Volume
- 101
- Issue
- 4
- Pages
- 805-815
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- OpenAlex
- W2086585598
- Cited by
- 646
- References
- 63
- Citations by year
- 2026: 15 · 2025: 27 · 2024: 35 · 2023: 39 · 2022: 42 · 2021: 39 · 2020: 54 · 2019: 41 · 2018: 53 · 2017: 44 · 2016: 42 · 2015: 30 · 2014: 32 · 2013: 26 · 2012: 27
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA119061)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- tumor microenvironment, tumor stroma, stromal cells, tumor growth, metastasis, metastatic sites, treatment response, bone marrow-derived cells, tumor cell dynamics
- MeSH terms
- Animals, Bone Marrow Cells, Epithelial Cells, Humans, Models, Biological, Neoplasms, Stromal Cells, Mesenchymal Stem Cells
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