Cited by 646Cancer Cells and MetastasisImmune cells in cancerAngiogenesis and VEGF in Cancer

Tumor microenvironment: The role of the tumor stroma in cancer

Li, Hanchen, Fan, Xueli, Houghton, JeanMarie·2007·Journal of Cellular Biochemistry

Abstract

The tumor microenvironment, composed of non‐cancer cells and their stroma, has become recognized as a major factor influencing the growth of cancer. The microenvironment has been implicated in the regulation of cell growth, determining metastatic potential and possibly determining location of metastatic disease, and impacting the outcome of therapy. While the stromal cells are not malignant per se, their role in supporting cancer growth is so vital to the survival of the tumor that they have become an attractive target for chemotherapeutic agents. In this review, we will discuss the various cellular and molecular components of the stromal environment, their effects on cancer cell dynamics, and the rationale and implications of targeting this environment for control of cancer. Additionally, we will emphasize the role of the bone marrow‐derived cell in providing cells for the stroma. J. Cell. Biochem. 101: 805–815, 2007. © 2007 Wiley‐Liss, Inc.

Integrity signals

Registry

Crossref · 10.1002/jcb.21159

Cites

63 of 63 references verified0 citation errors · 0 not checkable

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  • Stromal cells of the tumor microenvironment play a major part in cancer, and their communication with cancer cells is associated with regulation of tumor growth, metastasis, and treatment outcome.

    “The stromal cells of the tumor microenvironment play a major part in cancer, and their communication with cancer cells has been associated with the regulation of tumor growth, metastasis, and even treatment outcome, making them attractive targets for cancer treatment. 43”

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Authors
Li, H., Fan, X., & Houghton, J.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Houghton, JeanMarie
Venue
Journal of Cellular Biochemistry
Publisher
Wiley
Published
2007-01-16
Volume
101
Issue
4
Pages
805-815
ISSN
  • 0730-2312 (ISSN-L)
  • 1097-4644
OpenAlex
W2086585598
Cited by
646
References
63
Citations by year
2026: 15 · 2025: 27 · 2024: 35 · 2023: 39 · 2022: 42 · 2021: 39 · 2020: 54 · 2019: 41 · 2018: 53 · 2017: 44 · 2016: 42 · 2015: 30 · 2014: 32 · 2013: 26 · 2012: 27
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA119061)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
tumor microenvironment, tumor stroma, stromal cells, tumor growth, metastasis, metastatic sites, treatment response, bone marrow-derived cells, tumor cell dynamics
MeSH terms
Animals, Bone Marrow Cells, Epithelial Cells, Humans, Models, Biological, Neoplasms, Stromal Cells, Mesenchymal Stem Cells

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