Cited by 299Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsBlood Pressure and Hypertension Studies

The relationship between blood pressure and cognitive function

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Novak, Vera, Hajjar, Ihab·2010·Nature Reviews Cardiology

Abstract

The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure-perfusion-cognition relationships. A decline in vascular reserve capacity can lead to impaired neurovascular coupling and decreased cognitive ability. Endothelial dysfunction, microvascular disease, and mascrovascular disease in midlife could also have an important role in the manifestations and severity of multiple medical conditions underlying cognitive decline late in life. However, questions remain about the role of antihypertensive therapies for long-term prevention of cognitive decline. In this Review, we address the underlying pathophysiology and the existing evidence supporting the role of vascular factors in late-life cognitive decline.

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Authors
Novak, V., & Hajjar, I.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Novak, Vera
Venue
Nature Reviews Cardiology
Published
2010-10-26
Volume
7
Issue
12
Pages
686-698
ISSN
  • 1759-5002 (ISSN-L)
  • 1759-5010
OpenAlex
W2048075564
Cited by
299
References
122
Citations by year
2026: 11 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 24 · 2021: 15 · 2020: 20 · 2019: 29 · 2018: 15 · 2017: 28 · 2016: 16 · 2015: 19 · 2014: 30 · 2013: 31 · 2012: 20
FWCI
2.77
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (1R01AG028076-A2, R01AG028076, P30AG028717, 1P01AG028717-01A2, K23AG030057)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084463)
  • National Institute of Neurological Disorders and Stroke (R01NS045745)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
blood pressure, cognitive decline, dementia, hypertension, hypotension, cerebral perfusion, cerebrovascular reserve, neurovascular coupling, vascular risk factors, endothelial dysfunction, microangiopathy, macroangiopathy, antihypertensive therapy, executive function, attention, older adults
MeSH terms
Age Factors, Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Cognition, Cognition Disorders, Female, Humans, Hypertension, Hypotension, Male, Middle Aged, Risk Factors, Risk Assessment

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